Postsynaptic NO/cGMP increases NMDA receptor currents via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus

The nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling cascade participates in the modulation of synaptic transmission. The effects of NO are mediated by the NO-sensitive cGMP-forming guanylyl cyclases (NO-GCs), which exist in 2 isoforms with indistinguishable regulatory properties. T...

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Veröffentlicht in:	Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2014-07, Vol.24 (7), p.1923-1936
Hauptverfasser:	Neitz, Angela, Mergia, Evanthia, Imbrosci, Barbara, Petrasch-Parwez, Elisabeth, Eysel, Ulf T, Koesling, Doris, Mittmann, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Local - pharmacology Animals Animals, Newborn CA1 Region, Hippocampal - cytology Cyclic GMP - metabolism Cyclic GMP - pharmacology Electric Stimulation Excitatory Amino Acid Antagonists - pharmacology Guanylate Cyclase - genetics Guanylate Cyclase - metabolism Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism In Vitro Techniques Lidocaine - analogs & derivatives Lidocaine - pharmacology Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Mice Mice, Knockout Neurons - drug effects Neurons - physiology Nitric Oxide - deficiency Nitric Oxide - genetics Patch-Clamp Techniques Pyrimidines - pharmacology Receptors, N-Methyl-D-Aspartate - metabolism Tetraethylammonium - pharmacology
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