Functional effects of dopamine transporter gene genotypes on in vivo dopamine transporter functioning: a meta-analysis

Much psychiatric genetic research has focused on a 40-base pair variable number of tandem repeats (VNTR) polymorphism located in the 3′-untranslated region (3′UTR) of the dopamine active transporter (DAT) gene ( SLC6A3 ). This variant produces two common alleles with 9- and 10-repeats (9R and 10R)....

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Veröffentlicht in:	Molecular psychiatry 2014-08, Vol.19 (8), p.880-889
Hauptverfasser:	Faraone, S V, Spencer, T J, Madras, B K, Zhang-James, Y, Biederman, J
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions 631/208 631/378/2587 692/699/476/1311 Adolescent Adult Aged Aged, 80 and over Alleles Attention deficit disorders. Hyperactivity Behavioral Sciences Biological and medical sciences Biological Psychology Child clinical studies Computed tomography Development and progression DNA binding proteins Dopamine Dopamine Plasma Membrane Transport Proteins - genetics Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine transporter Dopaminergic mechanisms Functional Neuroimaging Gene polymorphism Genetic analysis Genetic aspects Genetic research Genotype Humans Medical sciences Medicine Medicine & Public Health Mental illness Meta-analysis Middle Aged Minisatellite Repeats - genetics Neostriatum Neurosciences original-article Pharmacotherapy Physiological aspects Polymorphism Positron emission tomography Psychiatric research Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Single photon emission computed tomography Systematic review Tomography Tomography, Emission-Computed, Single-Photon Young Adult
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