The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

The function of the lymphocyte-expressed receptor CD96 is almost entirely unknown. Smyth and colleagues demonstrate that it serves a key role in restraining activation of NK cells in part by competing with the activating receptor CD226 (DNAM-1). CD96, CD226 (DNAM-1) and TIGIT belong to an emerging f...

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Veröffentlicht in:	Nature immunology 2014-05, Vol.15 (5), p.431-438
Hauptverfasser:	Chan, Christopher J, Martinet, Ludovic, Gilfillan, Susan, Souza-Fonseca-Guimaraes, Fernando, Chow, Melvyn T, Town, Liam, Ritchie, David S, Colonna, Marco, Andrews, Daniel M, Smyth, Mark J
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/31 631/250 64 64/110 64/60 82 Animals Antigens, CD - genetics Antigens, CD - metabolism Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - metabolism Biomedicine Carcinogenesis Cell Adhesion Molecules - metabolism Cell receptors Cells, Cultured Cellular control mechanisms Cytotoxicity Cytotoxicity, Immunologic - genetics Immunology Infectious Diseases Killer cells Killer Cells, Natural - immunology Lipopolysaccharides - immunology Lung Neoplasms - immunology Mice Mice, Inbred C57BL Mice, Knockout Nectins Neoplasm Metastasis Neoplasms, Experimental - immunology Physiological aspects Physiological research Pneumonia - immunology Protein Binding - genetics Receptors, Immunologic - metabolism Receptors, Virus - metabolism
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