Serotonin transporter gene promoter polymorphism (5-HTTLPR) and alcohol use in general population: interaction effect with birth cohort
Rationale and objective Prevalence of alcohol use is markedly influenced by socioeconomic conditions and is therefore subject to cohort effects. The common genetic variation 5-HTTLPR (serotonin transporter gene-linked polymorphic region) has been related to several aspects of alcohol use and addicti...
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| Veröffentlicht in: | Psychopharmacology 2014-07, Vol.231 (13), p.2587-2594 |
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| creator | Vaht, Mariliis Merenäkk, Liis Mäestu, Jarek Veidebaum, Toomas Harro, Jaanus |
| description | Rationale and objective
Prevalence of alcohol use is markedly influenced by socioeconomic conditions and is therefore subject to cohort effects. The common genetic variation 5-HTTLPR (serotonin transporter gene-linked polymorphic region) has been related to several aspects of alcohol use and addiction but with mixed results, probably due to different environmental interaction effects. We aimed at assessing whether the association between alcohol use and 5-HTTLPR genotype is subject to cohort effects as birth cohorts may be raised in significantly different environments.
Methods
We used the database of the Estonian Children Personality Behaviour and Health Study (beginning in 1998). Cohorts of initially 9-year-old (recalled at ages 15 and 18) and 15-year-old (recalled at ages 18 and 25) children provided self-reports on their alcohol use in all data collection waves (complete data available
n
= 1,075).
Results
A significant genotype × gender × cohort interaction effect on the age of consuming the first alcoholic drink was found [
F
(2, 1,063) = 7.2,
p
|
| doi_str_mv | 10.1007/s00213-013-3427-8 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1554952763</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A374333662</galeid><sourcerecordid>A374333662</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-934559227bdff6f3e5087ed1a7791ed32d507898cdde89585e8c1b63d7a0e8153</originalsourceid><addsrcrecordid>eNp1Udtu1DAQtRCIlsIH8IIs8VIeUnyNHd6qCijSSiBYni2vM9lNldjBToT6Bfw2E225CjyyrZk552jsQ8hTzi44Y-ZlYUxwWTHcUglT2XvklCspKsGMuE9OGZPY4dqekEel3DBcyqqH5EQoxSxST8m3T5DTnGIf6Zx9LFPKM2S6hwh0ymlMazal4XZMeTr0ZaTnurrebjcfPr6gPrbUDyEd0kCXAhRFVmL2A1KmZfBzn-IrLKOID2tCoesgzPRrPx_ors94rvQ8PyYPOj8UeHJ3n5HPb15vr66rzfu3764uN1XQSsxVI5XWjRBm13Zd3UnQzBpouTem4dBK0WpmbGND24JttNVgA9_VsjWegeVanpHzoy4-7ssCZXZjXwIMg4-QluK41qrRwtQSoc__gt6kJUecDlESo5ZM_ELt_QCuj13CfwyrqLuURkkp63pFXfwDhdHC2IcUoeux_geBHwkhp1IydG7K_ejzrePMrea7o_kOzXer-c4i59ndwMtuhPYn44fbCBBHQMFW3EP-7UX_Vf0O70q48Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1535356302</pqid></control><display><type>article</type><title>Serotonin transporter gene promoter polymorphism (5-HTTLPR) and alcohol use in general population: interaction effect with birth cohort</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Vaht, Mariliis ; Merenäkk, Liis ; Mäestu, Jarek ; Veidebaum, Toomas ; Harro, Jaanus</creator><creatorcontrib>Vaht, Mariliis ; Merenäkk, Liis ; Mäestu, Jarek ; Veidebaum, Toomas ; Harro, Jaanus</creatorcontrib><description>Rationale and objective
Prevalence of alcohol use is markedly influenced by socioeconomic conditions and is therefore subject to cohort effects. The common genetic variation 5-HTTLPR (serotonin transporter gene-linked polymorphic region) has been related to several aspects of alcohol use and addiction but with mixed results, probably due to different environmental interaction effects. We aimed at assessing whether the association between alcohol use and 5-HTTLPR genotype is subject to cohort effects as birth cohorts may be raised in significantly different environments.
Methods
We used the database of the Estonian Children Personality Behaviour and Health Study (beginning in 1998). Cohorts of initially 9-year-old (recalled at ages 15 and 18) and 15-year-old (recalled at ages 18 and 25) children provided self-reports on their alcohol use in all data collection waves (complete data available
n
= 1,075).
Results
A significant genotype × gender × cohort interaction effect on the age of consuming the first alcoholic drink was found [
F
(2, 1,063) = 7.2,
p
< 0.001]. Females with the s/s genotype in the older cohort were the latest experimenters with alcohol, while the s/s females of younger cohort had tried alcohol earlier than any other group. In males, there was no significant cohort × genotype interaction, but the 5-HTTLPR genotype was associated with alcohol use, the s/s subjects reporting the highest consumption.
Conclusion
Expression of genetic vulnerability to alcohol use is influenced by birth cohort effects. The 5-HTTLPR genotype is associated with alcohol consumption in general population, but the effect depends on gender and birth cohort.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-013-3427-8</identifier><identifier>PMID: 24408213</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Age Factors ; Alcohol Drinking - epidemiology ; Alcohol Drinking - genetics ; Alcohol use ; Analysis ; Biomedical and Life Sciences ; Biomedicine ; Carrier proteins ; Child ; Cohort Studies ; Databases, Factual ; Drinking of alcoholic beverages ; Environment ; Estonia - epidemiology ; Female ; Gender ; Genetic aspects ; Genetic polymorphisms ; Genetic Variation ; Genetics ; Genotype ; Humans ; Longitudinal Studies ; Male ; Neurosciences ; Original Investigation ; Pharmacology/Toxicology ; Psychiatry ; Serotonin Plasma Membrane Transport Proteins - genetics ; Sex Factors ; Young Adult</subject><ispartof>Psychopharmacology, 2014-07, Vol.231 (13), p.2587-2594</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-934559227bdff6f3e5087ed1a7791ed32d507898cdde89585e8c1b63d7a0e8153</citedby><cites>FETCH-LOGICAL-c542t-934559227bdff6f3e5087ed1a7791ed32d507898cdde89585e8c1b63d7a0e8153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-013-3427-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-013-3427-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24408213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaht, Mariliis</creatorcontrib><creatorcontrib>Merenäkk, Liis</creatorcontrib><creatorcontrib>Mäestu, Jarek</creatorcontrib><creatorcontrib>Veidebaum, Toomas</creatorcontrib><creatorcontrib>Harro, Jaanus</creatorcontrib><title>Serotonin transporter gene promoter polymorphism (5-HTTLPR) and alcohol use in general population: interaction effect with birth cohort</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Rationale and objective
Prevalence of alcohol use is markedly influenced by socioeconomic conditions and is therefore subject to cohort effects. The common genetic variation 5-HTTLPR (serotonin transporter gene-linked polymorphic region) has been related to several aspects of alcohol use and addiction but with mixed results, probably due to different environmental interaction effects. We aimed at assessing whether the association between alcohol use and 5-HTTLPR genotype is subject to cohort effects as birth cohorts may be raised in significantly different environments.
Methods
We used the database of the Estonian Children Personality Behaviour and Health Study (beginning in 1998). Cohorts of initially 9-year-old (recalled at ages 15 and 18) and 15-year-old (recalled at ages 18 and 25) children provided self-reports on their alcohol use in all data collection waves (complete data available
n
= 1,075).
Results
A significant genotype × gender × cohort interaction effect on the age of consuming the first alcoholic drink was found [
F
(2, 1,063) = 7.2,
p
< 0.001]. Females with the s/s genotype in the older cohort were the latest experimenters with alcohol, while the s/s females of younger cohort had tried alcohol earlier than any other group. In males, there was no significant cohort × genotype interaction, but the 5-HTTLPR genotype was associated with alcohol use, the s/s subjects reporting the highest consumption.
Conclusion
Expression of genetic vulnerability to alcohol use is influenced by birth cohort effects. The 5-HTTLPR genotype is associated with alcohol consumption in general population, but the effect depends on gender and birth cohort.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Alcohol Drinking - genetics</subject><subject>Alcohol use</subject><subject>Analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carrier proteins</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Databases, Factual</subject><subject>Drinking of alcoholic beverages</subject><subject>Environment</subject><subject>Estonia - epidemiology</subject><subject>Female</subject><subject>Gender</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Variation</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Neurosciences</subject><subject>Original Investigation</subject><subject>Pharmacology/Toxicology</subject><subject>Psychiatry</subject><subject>Serotonin Plasma Membrane Transport Proteins - genetics</subject><subject>Sex Factors</subject><subject>Young Adult</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1Udtu1DAQtRCIlsIH8IIs8VIeUnyNHd6qCijSSiBYni2vM9lNldjBToT6Bfw2E225CjyyrZk552jsQ8hTzi44Y-ZlYUxwWTHcUglT2XvklCspKsGMuE9OGZPY4dqekEel3DBcyqqH5EQoxSxST8m3T5DTnGIf6Zx9LFPKM2S6hwh0ymlMazal4XZMeTr0ZaTnurrebjcfPr6gPrbUDyEd0kCXAhRFVmL2A1KmZfBzn-IrLKOID2tCoesgzPRrPx_ors94rvQ8PyYPOj8UeHJ3n5HPb15vr66rzfu3764uN1XQSsxVI5XWjRBm13Zd3UnQzBpouTem4dBK0WpmbGND24JttNVgA9_VsjWegeVanpHzoy4-7ssCZXZjXwIMg4-QluK41qrRwtQSoc__gt6kJUecDlESo5ZM_ELt_QCuj13CfwyrqLuURkkp63pFXfwDhdHC2IcUoeux_geBHwkhp1IydG7K_ejzrePMrea7o_kOzXer-c4i59ndwMtuhPYn44fbCBBHQMFW3EP-7UX_Vf0O70q48Q</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Vaht, Mariliis</creator><creator>Merenäkk, Liis</creator><creator>Mäestu, Jarek</creator><creator>Veidebaum, Toomas</creator><creator>Harro, Jaanus</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20140701</creationdate><title>Serotonin transporter gene promoter polymorphism (5-HTTLPR) and alcohol use in general population: interaction effect with birth cohort</title><author>Vaht, Mariliis ; Merenäkk, Liis ; Mäestu, Jarek ; Veidebaum, Toomas ; Harro, Jaanus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-934559227bdff6f3e5087ed1a7791ed32d507898cdde89585e8c1b63d7a0e8153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Alcohol Drinking - genetics</topic><topic>Alcohol use</topic><topic>Analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Carrier proteins</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Databases, Factual</topic><topic>Drinking of alcoholic beverages</topic><topic>Environment</topic><topic>Estonia - epidemiology</topic><topic>Female</topic><topic>Gender</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic Variation</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Neurosciences</topic><topic>Original Investigation</topic><topic>Pharmacology/Toxicology</topic><topic>Psychiatry</topic><topic>Serotonin Plasma Membrane Transport Proteins - genetics</topic><topic>Sex Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaht, Mariliis</creatorcontrib><creatorcontrib>Merenäkk, Liis</creatorcontrib><creatorcontrib>Mäestu, Jarek</creatorcontrib><creatorcontrib>Veidebaum, Toomas</creatorcontrib><creatorcontrib>Harro, Jaanus</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaht, Mariliis</au><au>Merenäkk, Liis</au><au>Mäestu, Jarek</au><au>Veidebaum, Toomas</au><au>Harro, Jaanus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonin transporter gene promoter polymorphism (5-HTTLPR) and alcohol use in general population: interaction effect with birth cohort</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>231</volume><issue>13</issue><spage>2587</spage><epage>2594</epage><pages>2587-2594</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Rationale and objective
Prevalence of alcohol use is markedly influenced by socioeconomic conditions and is therefore subject to cohort effects. The common genetic variation 5-HTTLPR (serotonin transporter gene-linked polymorphic region) has been related to several aspects of alcohol use and addiction but with mixed results, probably due to different environmental interaction effects. We aimed at assessing whether the association between alcohol use and 5-HTTLPR genotype is subject to cohort effects as birth cohorts may be raised in significantly different environments.
Methods
We used the database of the Estonian Children Personality Behaviour and Health Study (beginning in 1998). Cohorts of initially 9-year-old (recalled at ages 15 and 18) and 15-year-old (recalled at ages 18 and 25) children provided self-reports on their alcohol use in all data collection waves (complete data available
n
= 1,075).
Results
A significant genotype × gender × cohort interaction effect on the age of consuming the first alcoholic drink was found [
F
(2, 1,063) = 7.2,
p
< 0.001]. Females with the s/s genotype in the older cohort were the latest experimenters with alcohol, while the s/s females of younger cohort had tried alcohol earlier than any other group. In males, there was no significant cohort × genotype interaction, but the 5-HTTLPR genotype was associated with alcohol use, the s/s subjects reporting the highest consumption.
Conclusion
Expression of genetic vulnerability to alcohol use is influenced by birth cohort effects. The 5-HTTLPR genotype is associated with alcohol consumption in general population, but the effect depends on gender and birth cohort.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24408213</pmid><doi>10.1007/s00213-013-3427-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacology, 2014-07, Vol.231 (13), p.2587-2594 |
| issn | 0033-3158 1432-2072 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Age Factors Alcohol Drinking - epidemiology Alcohol Drinking - genetics Alcohol use Analysis Biomedical and Life Sciences Biomedicine Carrier proteins Child Cohort Studies Databases, Factual Drinking of alcoholic beverages Environment Estonia - epidemiology Female Gender Genetic aspects Genetic polymorphisms Genetic Variation Genetics Genotype Humans Longitudinal Studies Male Neurosciences Original Investigation Pharmacology/Toxicology Psychiatry Serotonin Plasma Membrane Transport Proteins - genetics Sex Factors Young Adult |
| title | Serotonin transporter gene promoter polymorphism (5-HTTLPR) and alcohol use in general population: interaction effect with birth cohort |
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