Prognostic Significance of Cyclin D1 and E-cadherin Expression in Laryngeal Squamous Cell Carcinoma
Cyclin D1 and E-cadherin are important factors in the progression and metastasis of cancers. Their role in laryngeal carcinoma has been studied with conflicting results. To define the frequency of cyclin D1 and E-cadherin expression and its correlation with both the clinicopathological characteristi...
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| description | Cyclin D1 and E-cadherin are important factors in the progression and metastasis of cancers. Their role in laryngeal carcinoma has been studied with conflicting results. To define the frequency of cyclin D1 and E-cadherin expression and its correlation with both the clinicopathological characteristics and prognosis of patients with laryngeal squamous cell carcinoma (LSCC). Tumor tissue samples from 75 patients with laryngeal squamous cell carcinoma were examined for cyclin D1 and E-cadherin expression by immunohistochemistry. The relationship between the expression of both molecules and the age and sex of the patient, tumor site, tumor differentiation, lymph node metastasis, tumor invasiveness, TNM stages, tumor recurrence and overall survival was analyzed. Cyclin D1 was found to be a significant independent prognostic factor of lymph node metastasis (
p
= 0.000). The multivariate analysis revealed that cyclin D1 and E-cadherin expression wasn’t an independent prognostic factor of local recurrence free survival (LRFS) in patients with LSCC (
P
= 0.56 and 0.28) respectively. However, the univariate analysis revealed a significant association between them and LRFS (
p
= 0.003 and 0.000) respectively. Also, the group of high cyclin D1 /low E-cadherin expression had the poorest prognosis, so they might serve as potential predictors of the prognosis of the patients with LSCC. E-cadherin was found to affect the overall survival (OAS) significantly by the univariate analysis (
p
= 0.01). However, by the multivariate analysis the TNM stage was the only independent prognostic factor of OAS (
p
|
| doi_str_mv | 10.1007/s12253-014-9741-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1554952718</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3338697131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-3181f73476aa6c4aef734f931bd151e0b8d4aed8c2085da4635513f161d5e72a3</originalsourceid><addsrcrecordid>eNqNkcuKFDEUhoMozjj6AG4k4MZNNCfXqqWU7QUaFEbXIZ1KtRmqkp6kC5y39zQ9igiCq-ScfOeS_yfkOfDXwLl900AILRkHxXqrgJkH5BK0FEx03D7Eu4CeqV6bC_KktRuONaY3j8mFUMpy0YlLEr7Uss-lHVOg12mf05SCzyHSMtHhLswp03dAfR7phgU_fo8VM5sfhxpbSyVTjLa-3uV99DO9vl39UtZGhzjPdPA1pFwW_5Q8mvzc4rP784p8e7_5Onxk288fPg1vtywoq49MQgeTlcoa701QPp6CqZewG0FD5LtuxOTYBcE7PXplpNYgJzAw6miFl1fk1bnvoZbbNbajW1ILuIrPEbdyoDWKISx0_4HKXpmeQ4_oy7_Qm7LWjB85URY06quQgjMVammtxskdalpQGQfcncxyZ7McmuVOZjmDNS_uO6-7JY6_K365g4A4Aw2fUOL6x-h_dv0JeAadTA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1537159564</pqid></control><display><type>article</type><title>Prognostic Significance of Cyclin D1 and E-cadherin Expression in Laryngeal Squamous Cell Carcinoma</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Ahmed, Rehab Allah ; Shawky, Abd El-Aty ; Hamed, Rasha Hamdy</creator><creatorcontrib>Ahmed, Rehab Allah ; Shawky, Abd El-Aty ; Hamed, Rasha Hamdy</creatorcontrib><description>Cyclin D1 and E-cadherin are important factors in the progression and metastasis of cancers. Their role in laryngeal carcinoma has been studied with conflicting results. To define the frequency of cyclin D1 and E-cadherin expression and its correlation with both the clinicopathological characteristics and prognosis of patients with laryngeal squamous cell carcinoma (LSCC). Tumor tissue samples from 75 patients with laryngeal squamous cell carcinoma were examined for cyclin D1 and E-cadherin expression by immunohistochemistry. The relationship between the expression of both molecules and the age and sex of the patient, tumor site, tumor differentiation, lymph node metastasis, tumor invasiveness, TNM stages, tumor recurrence and overall survival was analyzed. Cyclin D1 was found to be a significant independent prognostic factor of lymph node metastasis (
p
= 0.000). The multivariate analysis revealed that cyclin D1 and E-cadherin expression wasn’t an independent prognostic factor of local recurrence free survival (LRFS) in patients with LSCC (
P
= 0.56 and 0.28) respectively. However, the univariate analysis revealed a significant association between them and LRFS (
p
= 0.003 and 0.000) respectively. Also, the group of high cyclin D1 /low E-cadherin expression had the poorest prognosis, so they might serve as potential predictors of the prognosis of the patients with LSCC. E-cadherin was found to affect the overall survival (OAS) significantly by the univariate analysis (
p
= 0.01). However, by the multivariate analysis the TNM stage was the only independent prognostic factor of OAS (
p
< 0.05). Cyclin D1 can be used as an independent prognostic marker of lymph node metastasis in patients with LSCC and can help to identify those patients with clinically negative lymph nodes but with considerable risk for occult metastasis. Detection of cyclin D1 and E-cadherin status in LSCC may contribute to the identification of patients with high risk factors of local recurrence. However, they don’t appear to be better prognostic predictors than other established markers in LSCC.</description><identifier>ISSN: 1219-4956</identifier><identifier>EISSN: 1532-2807</identifier><identifier>DOI: 10.1007/s12253-014-9741-6</identifier><identifier>PMID: 24470282</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Cadherins - metabolism ; Cancer Research ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - secondary ; Cyclin D1 - metabolism ; Female ; Follow-Up Studies ; Humans ; Immunoenzyme Techniques ; Immunology ; Laryngeal Neoplasms - metabolism ; Laryngeal Neoplasms - mortality ; Laryngeal Neoplasms - pathology ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Neoplasm Staging ; Oncology ; Pathology ; Prognosis ; Survival Rate</subject><ispartof>Pathology oncology research, 2014-07, Vol.20 (3), p.625-633</ispartof><rights>Arányi Lajos Foundation 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-3181f73476aa6c4aef734f931bd151e0b8d4aed8c2085da4635513f161d5e72a3</citedby><cites>FETCH-LOGICAL-c475t-3181f73476aa6c4aef734f931bd151e0b8d4aed8c2085da4635513f161d5e72a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12253-014-9741-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12253-014-9741-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24470282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed, Rehab Allah</creatorcontrib><creatorcontrib>Shawky, Abd El-Aty</creatorcontrib><creatorcontrib>Hamed, Rasha Hamdy</creatorcontrib><title>Prognostic Significance of Cyclin D1 and E-cadherin Expression in Laryngeal Squamous Cell Carcinoma</title><title>Pathology oncology research</title><addtitle>Pathol. Oncol. Res</addtitle><addtitle>Pathol Oncol Res</addtitle><description>Cyclin D1 and E-cadherin are important factors in the progression and metastasis of cancers. Their role in laryngeal carcinoma has been studied with conflicting results. To define the frequency of cyclin D1 and E-cadherin expression and its correlation with both the clinicopathological characteristics and prognosis of patients with laryngeal squamous cell carcinoma (LSCC). Tumor tissue samples from 75 patients with laryngeal squamous cell carcinoma were examined for cyclin D1 and E-cadherin expression by immunohistochemistry. The relationship between the expression of both molecules and the age and sex of the patient, tumor site, tumor differentiation, lymph node metastasis, tumor invasiveness, TNM stages, tumor recurrence and overall survival was analyzed. Cyclin D1 was found to be a significant independent prognostic factor of lymph node metastasis (
p
= 0.000). The multivariate analysis revealed that cyclin D1 and E-cadherin expression wasn’t an independent prognostic factor of local recurrence free survival (LRFS) in patients with LSCC (
P
= 0.56 and 0.28) respectively. However, the univariate analysis revealed a significant association between them and LRFS (
p
= 0.003 and 0.000) respectively. Also, the group of high cyclin D1 /low E-cadherin expression had the poorest prognosis, so they might serve as potential predictors of the prognosis of the patients with LSCC. E-cadherin was found to affect the overall survival (OAS) significantly by the univariate analysis (
p
= 0.01). However, by the multivariate analysis the TNM stage was the only independent prognostic factor of OAS (
p
< 0.05). Cyclin D1 can be used as an independent prognostic marker of lymph node metastasis in patients with LSCC and can help to identify those patients with clinically negative lymph nodes but with considerable risk for occult metastasis. Detection of cyclin D1 and E-cadherin status in LSCC may contribute to the identification of patients with high risk factors of local recurrence. However, they don’t appear to be better prognostic predictors than other established markers in LSCC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cadherins - metabolism</subject><subject>Cancer Research</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Cyclin D1 - metabolism</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunology</subject><subject>Laryngeal Neoplasms - metabolism</subject><subject>Laryngeal Neoplasms - mortality</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Survival Rate</subject><issn>1219-4956</issn><issn>1532-2807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkcuKFDEUhoMozjj6AG4k4MZNNCfXqqWU7QUaFEbXIZ1KtRmqkp6kC5y39zQ9igiCq-ScfOeS_yfkOfDXwLl900AILRkHxXqrgJkH5BK0FEx03D7Eu4CeqV6bC_KktRuONaY3j8mFUMpy0YlLEr7Uss-lHVOg12mf05SCzyHSMtHhLswp03dAfR7phgU_fo8VM5sfhxpbSyVTjLa-3uV99DO9vl39UtZGhzjPdPA1pFwW_5Q8mvzc4rP784p8e7_5Onxk288fPg1vtywoq49MQgeTlcoa701QPp6CqZewG0FD5LtuxOTYBcE7PXplpNYgJzAw6miFl1fk1bnvoZbbNbajW1ILuIrPEbdyoDWKISx0_4HKXpmeQ4_oy7_Qm7LWjB85URY06quQgjMVammtxskdalpQGQfcncxyZ7McmuVOZjmDNS_uO6-7JY6_K365g4A4Aw2fUOL6x-h_dv0JeAadTA</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Ahmed, Rehab Allah</creator><creator>Shawky, Abd El-Aty</creator><creator>Hamed, Rasha Hamdy</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20140701</creationdate><title>Prognostic Significance of Cyclin D1 and E-cadherin Expression in Laryngeal Squamous Cell Carcinoma</title><author>Ahmed, Rehab Allah ; Shawky, Abd El-Aty ; Hamed, Rasha Hamdy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-3181f73476aa6c4aef734f931bd151e0b8d4aed8c2085da4635513f161d5e72a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cadherins - metabolism</topic><topic>Cancer Research</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Cyclin D1 - metabolism</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunology</topic><topic>Laryngeal Neoplasms - metabolism</topic><topic>Laryngeal Neoplasms - mortality</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Pathology</topic><topic>Prognosis</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Rehab Allah</creatorcontrib><creatorcontrib>Shawky, Abd El-Aty</creatorcontrib><creatorcontrib>Hamed, Rasha Hamdy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pathology oncology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Rehab Allah</au><au>Shawky, Abd El-Aty</au><au>Hamed, Rasha Hamdy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significance of Cyclin D1 and E-cadherin Expression in Laryngeal Squamous Cell Carcinoma</atitle><jtitle>Pathology oncology research</jtitle><stitle>Pathol. Oncol. Res</stitle><addtitle>Pathol Oncol Res</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>20</volume><issue>3</issue><spage>625</spage><epage>633</epage><pages>625-633</pages><issn>1219-4956</issn><eissn>1532-2807</eissn><abstract>Cyclin D1 and E-cadherin are important factors in the progression and metastasis of cancers. Their role in laryngeal carcinoma has been studied with conflicting results. To define the frequency of cyclin D1 and E-cadherin expression and its correlation with both the clinicopathological characteristics and prognosis of patients with laryngeal squamous cell carcinoma (LSCC). Tumor tissue samples from 75 patients with laryngeal squamous cell carcinoma were examined for cyclin D1 and E-cadherin expression by immunohistochemistry. The relationship between the expression of both molecules and the age and sex of the patient, tumor site, tumor differentiation, lymph node metastasis, tumor invasiveness, TNM stages, tumor recurrence and overall survival was analyzed. Cyclin D1 was found to be a significant independent prognostic factor of lymph node metastasis (
p
= 0.000). The multivariate analysis revealed that cyclin D1 and E-cadherin expression wasn’t an independent prognostic factor of local recurrence free survival (LRFS) in patients with LSCC (
P
= 0.56 and 0.28) respectively. However, the univariate analysis revealed a significant association between them and LRFS (
p
= 0.003 and 0.000) respectively. Also, the group of high cyclin D1 /low E-cadherin expression had the poorest prognosis, so they might serve as potential predictors of the prognosis of the patients with LSCC. E-cadherin was found to affect the overall survival (OAS) significantly by the univariate analysis (
p
= 0.01). However, by the multivariate analysis the TNM stage was the only independent prognostic factor of OAS (
p
< 0.05). Cyclin D1 can be used as an independent prognostic marker of lymph node metastasis in patients with LSCC and can help to identify those patients with clinically negative lymph nodes but with considerable risk for occult metastasis. Detection of cyclin D1 and E-cadherin status in LSCC may contribute to the identification of patients with high risk factors of local recurrence. However, they don’t appear to be better prognostic predictors than other established markers in LSCC.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24470282</pmid><doi>10.1007/s12253-014-9741-6</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cadherins - metabolism Cancer Research Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - secondary Cyclin D1 - metabolism Female Follow-Up Studies Humans Immunoenzyme Techniques Immunology Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - mortality Laryngeal Neoplasms - pathology Lymphatic Metastasis Male Middle Aged Neoplasm Grading Neoplasm Invasiveness Neoplasm Staging Oncology Pathology Prognosis Survival Rate |
| title | Prognostic Significance of Cyclin D1 and E-cadherin Expression in Laryngeal Squamous Cell Carcinoma |
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