p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation

p53 is one of the most studied genes in cancer biology, and mutations in this gene may be predictive for the development of many types of cancer in humans and in animals. However, whether p53 mutations in non -tumor stromal cells can affect tumor development has received very little attention. In th...

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Veröffentlicht in:	Oncogene 2014-07, Vol.33 (29), p.3830-3838
Hauptverfasser:	Huang, Y, Yu, P, Li, W, Ren, G, Roberts, A I, Cao, W, Zhang, X, Su, J, Chen, X, Chen, Q, Shou, P, Xu, C, Du, L, Lin, L, Xie, N, Zhang, L, Wang, Y, Shi, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	631/532/2074 631/67/1813/1634 631/67/327 631/67/581 Animals Apoptosis Cancer Cell Biology Cytokines - biosynthesis Disease Models, Animal Gene expression Genetic regulation Human Genetics Immune response Immune system Immunomodulation - genetics Inflammation Mediators Internal Medicine Medicine Medicine & Public Health Melanoma, Experimental Mesenchymal Stromal Cells - metabolism Mice Mice, Knockout Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - metabolism Oncology original-article Physiological aspects Stem cells Tumor Microenvironment - genetics Tumor Microenvironment - immunology Tumor suppressor genes Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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