Coordinated regulation of the immunoproteasome subunits by PML/RARα and PU.1 in acute promyelocytic leukemia

Recognition and elimination of malignant cells by cytotoxic T lymphocytes depends on antigenic peptides generated by proteasomes. It has been established that impairment of the immunoproteasome subunits, that is, PSMB8, PSMB9 and PSMB10 (PSMBs), is critical for malignant cells to escape immune recog...

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Veröffentlicht in:	Oncogene 2014-05, Vol.33 (21), p.2700-2708
Hauptverfasser:	Yang, X-W, Wang, P, Liu, J-Q, Zhang, H, Xi, W-D, Jia, X-H, Wang, K-K
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/474/2085 631/67/580 692/699/67/1990/283/1897 Acute myeloid leukemia Acute promyeloid leukemia Antigen Presentation Antigen processing Apoptosis Arsenic Arsenic trioxide Arsenicals - pharmacology Cell Biology Chromatin Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Cytotoxicity Gene Expression Regulation, Enzymologic Gene Expression Regulation, Leukemic Genetic research HL-60 Cells Human Genetics Humans Immune response Immunologic Factors - pharmacology Immunomodulation Immunoprecipitation Immunosurveillance Internal Medicine Leukemia Leukemia, Promyelocytic, Acute - enzymology Leukemia, Promyelocytic, Acute - genetics Lymphocytes T Medicine Medicine & Public Health Nuclear Proteins - metabolism Oncology original-article Oxides - pharmacology Patients Promoter Regions, Genetic Promyelocytic Leukemia Protein Promyeloid leukemia Properties Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Proteasomes Protein Binding Protein Subunits - metabolism Proto-Oncogene Proteins - metabolism PU.1 protein Receptors, Retinoic Acid - metabolism Retinoic acid Retinoic Acid Receptor alpha Trans-Activators - metabolism Transcription Transcription Factors - metabolism Transcriptional Activation Transcriptome Tretinoin - pharmacology Tumor Escape Tumor Suppressor Proteins - metabolism Ubiquitin-proteasome system
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