Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin

Activated microglia and macrophages play a key role in driving demyelination during multiple sclerosis (MS), but the factors responsible for their activation remain poorly understood. Here, we present evidence for a dual-trigger role of IFN-γ and alpha B-crystallin (HSPB5) in this context. In MS-aff...

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Veröffentlicht in:	Acta neuropathologica 2014-08, Vol.128 (2), p.215-229
Hauptverfasser:	Bsibsi, Malika, Peferoen, Laura A. N., Holtman, Inge R., Nacken, Peter J., Gerritsen, Wouter H., Witte, Maarten E., van Horssen, Jack, Eggen, Bart J. L., van der Valk, Paul, Amor, Sandra, van Noort, Johannes M.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Crystallin B Chain - metabolism Brain - immunology Brain - pathology Cells, Cultured Chemokine CXCL10 - metabolism Chemokine CXCL11 - metabolism Chemokine CXCL9 - metabolism Glycogen Synthase Kinase 3 - metabolism Hostages Humans Interferon Interferon-gamma - metabolism Interleukin-10 - metabolism Interleukin-12 - metabolism Interleukin-1beta - metabolism Interleukin-6 - metabolism Macrophages - pathology Macrophages - physiology Medicine Medicine & Public Health Microglia - pathology Microglia - physiology Multiple sclerosis Multiple Sclerosis - immunology Multiple Sclerosis - pathology Neurosciences Original Paper Pathology Protein binding Tumor Necrosis Factor-alpha - metabolism Ubiquitins - metabolism
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