Pyroglutamylated amyloid-β is associated with hyperphosphorylated tau and severity of Alzheimer’s disease

Pyroglutamylated amyloid-β (pE(3)-Aβ) has been suggested to play a major role in Alzheimer’s disease (AD) pathogenesis as amyloid-β (Aβ) oligomers containing pE(3)-Aβ might initiate tau-dependent cytotoxicity. We aimed to further elucidate the associations among pE(3)-Aβ, full-length Aβ and hyperpho...

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Veröffentlicht in:	Acta neuropathologica 2014-07, Vol.128 (1), p.67-79
Hauptverfasser:	Mandler, Markus, Walker, Lauren, Santic, Radmila, Hanson, Peter, Upadhaya, Ajeet Rijal, Colloby, Sean J., Morris, Christopher M., Thal, Dietmar R., Thomas, Alan J., Schneeberger, Achim, Attems, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Activities of daily living Aged Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - metabolism Analysis Blotting, Western Brain Cell Membrane - metabolism Entorhinal Cortex - metabolism Entorhinal Cortex - pathology Female Frontal Lobe - metabolism Frontal Lobe - pathology Humans Image Processing, Computer-Assisted Male Medicine Medicine & Public Health Neurophysiology Neuropsychological Tests Neurosciences Oligomers Original Paper Pathology Peptide Fragments - metabolism Phosphorylation Photomicrography Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Severity of Illness Index tau Proteins - metabolism
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