Rare insights into cancer biology

Cancer-associated mutations have been identified in the metabolic genes succinate dehydrogenase ( SDH ), fumarate hydratase ( FH ) and isocitrate dehydrogenase ( IDH ), advancing and challenging our understanding of cellular function and disease mechanisms and providing direct links between dysregul...

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Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2014-05, Vol.33 (20), p.2547-2556
Hauptverfasser:	Adam, J, Yang, M, Soga, T, Pollard, P J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/320 631/67 Animal models Apoptosis Cancer Cancer research Carcinoma, Renal cell Cell Biology Collecting duct Cytosine Dehydrogenases Demethylation Deoxyribonucleic acid Development and progression DNA Enzymatic activity Fibroids Fumarase Genetic aspects Histones Human Genetics Humans Hypoxia-inducible factors Internal Medicine Isocitrate dehydrogenase Ketoglutaric acid Kidney cancer Medicine Medicine & Public Health Metabolic regulation Metabolism Mutation Neoplasms - enzymology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncology Rare diseases review Smooth muscle Succinate dehydrogenase Succinate dehydrogenase complex Tumor markers Tumors Uterine cancer Uterus
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