Circadian behavior is light-reprogrammed by plastic DNA methylation

In this study, the authors show that altering the photoperiod of mice results in reversible transcriptional and DNA methylation changes in the suprachiasmatic nucleus. Application of a methyltransferase inhibitor blocks the light-entrained changes in the circadian period, suggesting that these methy...

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Veröffentlicht in:	Nature neuroscience 2014-03, Vol.17 (3), p.377-382
Hauptverfasser:	Azzi, Abdelhalim, Dallmann, Robert, Casserly, Alison, Rehrauer, Hubert, Patrignani, Andrea, Maier, Bert, Kramer, Achim, Brown, Steven A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1385/1330 Actigraphy Animal Genetics and Genomics Animals Behavior Behavior, Animal - physiology Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Circadian rhythm Circadian Rhythm - genetics Circadian Rhythm Signaling Peptides and Proteins - genetics Circadian Rhythm Signaling Peptides and Proteins - metabolism Circadian rhythms DNA DNA methylation DNA Methylation - genetics Epigenetic inheritance Epigenetics Gene expression Genomes Hypothalamus Light Lighting Methylation Mice Mice, Inbred C57BL Neurobiology Neuronal Plasticity - physiology Neurosciences Photoperiod Physiological aspects Suprachiasmatic Nucleus - metabolism Transcriptome - genetics Twin studies Twins
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