Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster

Patrick H O'Farrell and colleagues show not only that deleterious variants are selected against but that complementing mutant mitochondria are selected at characteristic stable ratios. It is not known how selection affects mutations in the multiple copies of the mitochondrial genome 1 , 2 , 3 ,...

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Veröffentlicht in:	Nature genetics 2014-04, Vol.46 (4), p.393-397
Hauptverfasser:	Ma, Hansong, Xu, Hong, O'Farrell, Patrick H
Format:	Artikel
Sprache:	eng
Schlagworte:	38/22 38/77 631/208 64/24 Agriculture Animal Genetics and Genomics Animals Biomedicine Blotting, Southern Cancer Research Competition DNA, Mitochondrial - genetics Drosophila Drosophila melanogaster Drosophila melanogaster - genetics Eggs Electron Transport Complex IV - genetics Fertility Gene Function Gene mutations Genes, Mitochondrial - genetics Genetic aspects Genomes Genotype Genotypes Human Genetics Identification and classification Insects letter Mitochondria Mitochondrial DNA Models, Genetic Mothers Mutation Mutation - genetics Polymerase Chain Reaction - methods Selection, Genetic - genetics Temperature
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