Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients
Purpose Adjunctive immunoadjuvant therapies are now proposed in the treatment of septic patients that develop immune dysfunctions. However, a prerequisite is to identify patients at high risk of death that would benefit from such therapy. Knowing that rhIL-7 is a putative candidate for septic shock...
Gespeichert in:
| Veröffentlicht in: | Intensive care medicine 2014-08, Vol.40 (8), p.1089-1096 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1096 |
|---|---|
| container_issue | 8 |
| container_start_page | 1089 |
| container_title | Intensive care medicine |
| container_volume | 40 |
| creator | Demaret, Julie Villars-Méchin, Astrid Lepape, Alain Plassais, Jonathan Vallin, Hélène Malcus, Christophe Poitevin-Later, Françoise Monneret, Guillaume Venet, Fabienne |
| description | Purpose
Adjunctive immunoadjuvant therapies are now proposed in the treatment of septic patients that develop immune dysfunctions. However, a prerequisite is to identify patients at high risk of death that would benefit from such therapy. Knowing that rhIL-7 is a putative candidate for septic shock treatment, we evaluated the association between increased plasmatic level of soluble CD127 (sCD127, IL-7 receptor alpha chain) and mortality after septic shock.
Methods
sCD127 plasmatic level was measured in 70 septic shock patients sampled at day 1–2 (D1) and day 3–4 (D3) after the onset of shock and 41 healthy volunteers.
Results
Compared with survivors, non-survivors presented with significantly higher sCD127 concentrations at D1 and D3 (
p
|
| doi_str_mv | 10.1007/s00134-014-3346-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1554949917</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A724301323</galeid><sourcerecordid>A724301323</sourcerecordid><originalsourceid>FETCH-LOGICAL-c580t-5e8fc946e64a7c10a496705bcdab77041aa0d9d2a0dc7f009d35bde4f78379603</originalsourceid><addsrcrecordid>eNqNkktv1DAUhSMEokPhB7BBltiwcbl-JE6WVVWg0khsYG05zs3UxYlT20PVf4_DlKcGCVmy5evvHPnap6peMjhjAOptAmBCUmCSCiEbCo-qDZOCU8ZF-7jagJCcykbyk-pZSjeFVk3NnlYnXHYNV6zdVLeXHr-ajANZvEmTyc6SUkFPwkhS8PveI7naUkUiWlxyiMQlYlIK1n2X3bl8TdxsI5pUtlOI2XiX70uNpCIofuk62C9kKd445_S8ejIan_DFw3pafX53-eniA91-fH91cb6ltm4h0xrb0XaywUYaZRmYcmUFdW8H0ysFkhkDQzfwMls1AnSDqPsB5ahaoboGxGn15uC7xHC7x5T15JJF782MYZ80q2vZya5j6j9Q2bLCgizo67_Qm7CPc2lkpVQNEprmF7UzHrWbx5CjsaupPldcivJtXBSKHqF2OGM0Psw4ulL-gz87wpcx4OTsUQE7CGwMKUUc9RLdZOK9ZqDXBOlDgnRJkF4TpNdne_XQ4L6fcPip-BGZAvADkMrRvMP42wv80_UbrKbOSg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1547504066</pqid></control><display><type>article</type><title>Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Demaret, Julie ; Villars-Méchin, Astrid ; Lepape, Alain ; Plassais, Jonathan ; Vallin, Hélène ; Malcus, Christophe ; Poitevin-Later, Françoise ; Monneret, Guillaume ; Venet, Fabienne</creator><creatorcontrib>Demaret, Julie ; Villars-Méchin, Astrid ; Lepape, Alain ; Plassais, Jonathan ; Vallin, Hélène ; Malcus, Christophe ; Poitevin-Later, Françoise ; Monneret, Guillaume ; Venet, Fabienne</creatorcontrib><description>Purpose
Adjunctive immunoadjuvant therapies are now proposed in the treatment of septic patients that develop immune dysfunctions. However, a prerequisite is to identify patients at high risk of death that would benefit from such therapy. Knowing that rhIL-7 is a putative candidate for septic shock treatment, we evaluated the association between increased plasmatic level of soluble CD127 (sCD127, IL-7 receptor alpha chain) and mortality after septic shock.
Methods
sCD127 plasmatic level was measured in 70 septic shock patients sampled at day 1–2 (D1) and day 3–4 (D3) after the onset of shock and 41 healthy volunteers.
Results
Compared with survivors, non-survivors presented with significantly higher sCD127 concentrations at D1 and D3 (
p
< 0.001 and
p
= 0.002). At D1, the area under the receiver operating characteristic curve for sCD127 level association with mortality was 0.846 (
p
< 0.0001). Kaplan–Meier survival curves illustrated that mortality was significantly different after stratification based on D1 sCD127 level (log rank test, hazard ratio 9.10,
p
< 0.0001). This association was preserved in multivariate logistic regression analysis including clinical confounders (age, SAPS II and SOFA scores, odds ratio 12.71,
p
= 0.003). Importantly, patient stratification on both D1 sCD127 value and SAPS II score improved this predictive capacity (log rank test,
p
= 0.0001).
Conclusions
Increased sCD127 plasmatic level enables the identification of a group of septic shock patients at high risk of death. After confirmation in a larger cohort, this biomarker may be of interest for patient stratification in future clinical trials.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/s00134-014-3346-0</identifier><identifier>PMID: 24962718</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Analysis ; Anesthesiology ; Biomarkers ; Biomarkers - blood ; Clinical trials ; Critical Care Medicine ; Cytokines ; Emergency Medicine ; Female ; Hospitals ; Humans ; Intensive ; Intensive care ; Interleukin-7 Receptor alpha Subunit - blood ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Nosocomial infections ; Original ; Pain Medicine ; Patient outcomes ; Patients ; Pediatrics ; Pneumology/Respiratory System ; Regression Analysis ; Sepsis ; Septic shock ; Shock, Septic - blood ; Shock, Septic - mortality ; Viral infections</subject><ispartof>Intensive care medicine, 2014-08, Vol.40 (8), p.1089-1096</ispartof><rights>Springer-Verlag Berlin Heidelberg and ESICM 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c580t-5e8fc946e64a7c10a496705bcdab77041aa0d9d2a0dc7f009d35bde4f78379603</citedby><cites>FETCH-LOGICAL-c580t-5e8fc946e64a7c10a496705bcdab77041aa0d9d2a0dc7f009d35bde4f78379603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00134-014-3346-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00134-014-3346-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24962718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demaret, Julie</creatorcontrib><creatorcontrib>Villars-Méchin, Astrid</creatorcontrib><creatorcontrib>Lepape, Alain</creatorcontrib><creatorcontrib>Plassais, Jonathan</creatorcontrib><creatorcontrib>Vallin, Hélène</creatorcontrib><creatorcontrib>Malcus, Christophe</creatorcontrib><creatorcontrib>Poitevin-Later, Françoise</creatorcontrib><creatorcontrib>Monneret, Guillaume</creatorcontrib><creatorcontrib>Venet, Fabienne</creatorcontrib><title>Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><addtitle>Intensive Care Med</addtitle><description>Purpose
Adjunctive immunoadjuvant therapies are now proposed in the treatment of septic patients that develop immune dysfunctions. However, a prerequisite is to identify patients at high risk of death that would benefit from such therapy. Knowing that rhIL-7 is a putative candidate for septic shock treatment, we evaluated the association between increased plasmatic level of soluble CD127 (sCD127, IL-7 receptor alpha chain) and mortality after septic shock.
Methods
sCD127 plasmatic level was measured in 70 septic shock patients sampled at day 1–2 (D1) and day 3–4 (D3) after the onset of shock and 41 healthy volunteers.
Results
Compared with survivors, non-survivors presented with significantly higher sCD127 concentrations at D1 and D3 (
p
< 0.001 and
p
= 0.002). At D1, the area under the receiver operating characteristic curve for sCD127 level association with mortality was 0.846 (
p
< 0.0001). Kaplan–Meier survival curves illustrated that mortality was significantly different after stratification based on D1 sCD127 level (log rank test, hazard ratio 9.10,
p
< 0.0001). This association was preserved in multivariate logistic regression analysis including clinical confounders (age, SAPS II and SOFA scores, odds ratio 12.71,
p
= 0.003). Importantly, patient stratification on both D1 sCD127 value and SAPS II score improved this predictive capacity (log rank test,
p
= 0.0001).
Conclusions
Increased sCD127 plasmatic level enables the identification of a group of septic shock patients at high risk of death. After confirmation in a larger cohort, this biomarker may be of interest for patient stratification in future clinical trials.</description><subject>Aged</subject><subject>Analysis</subject><subject>Anesthesiology</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Clinical trials</subject><subject>Critical Care Medicine</subject><subject>Cytokines</subject><subject>Emergency Medicine</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Intensive</subject><subject>Intensive care</subject><subject>Interleukin-7 Receptor alpha Subunit - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nosocomial infections</subject><subject>Original</subject><subject>Pain Medicine</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Pneumology/Respiratory System</subject><subject>Regression Analysis</subject><subject>Sepsis</subject><subject>Septic shock</subject><subject>Shock, Septic - blood</subject><subject>Shock, Septic - mortality</subject><subject>Viral infections</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkktv1DAUhSMEokPhB7BBltiwcbl-JE6WVVWg0khsYG05zs3UxYlT20PVf4_DlKcGCVmy5evvHPnap6peMjhjAOptAmBCUmCSCiEbCo-qDZOCU8ZF-7jagJCcykbyk-pZSjeFVk3NnlYnXHYNV6zdVLeXHr-ajANZvEmTyc6SUkFPwkhS8PveI7naUkUiWlxyiMQlYlIK1n2X3bl8TdxsI5pUtlOI2XiX70uNpCIofuk62C9kKd445_S8ejIan_DFw3pafX53-eniA91-fH91cb6ltm4h0xrb0XaywUYaZRmYcmUFdW8H0ysFkhkDQzfwMls1AnSDqPsB5ahaoboGxGn15uC7xHC7x5T15JJF782MYZ80q2vZya5j6j9Q2bLCgizo67_Qm7CPc2lkpVQNEprmF7UzHrWbx5CjsaupPldcivJtXBSKHqF2OGM0Psw4ulL-gz87wpcx4OTsUQE7CGwMKUUc9RLdZOK9ZqDXBOlDgnRJkF4TpNdne_XQ4L6fcPip-BGZAvADkMrRvMP42wv80_UbrKbOSg</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Demaret, Julie</creator><creator>Villars-Méchin, Astrid</creator><creator>Lepape, Alain</creator><creator>Plassais, Jonathan</creator><creator>Vallin, Hélène</creator><creator>Malcus, Christophe</creator><creator>Poitevin-Later, Françoise</creator><creator>Monneret, Guillaume</creator><creator>Venet, Fabienne</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20140801</creationdate><title>Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients</title><author>Demaret, Julie ; Villars-Méchin, Astrid ; Lepape, Alain ; Plassais, Jonathan ; Vallin, Hélène ; Malcus, Christophe ; Poitevin-Later, Françoise ; Monneret, Guillaume ; Venet, Fabienne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-5e8fc946e64a7c10a496705bcdab77041aa0d9d2a0dc7f009d35bde4f78379603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Analysis</topic><topic>Anesthesiology</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Clinical trials</topic><topic>Critical Care Medicine</topic><topic>Cytokines</topic><topic>Emergency Medicine</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Intensive</topic><topic>Intensive care</topic><topic>Interleukin-7 Receptor alpha Subunit - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Nosocomial infections</topic><topic>Original</topic><topic>Pain Medicine</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Pneumology/Respiratory System</topic><topic>Regression Analysis</topic><topic>Sepsis</topic><topic>Septic shock</topic><topic>Shock, Septic - blood</topic><topic>Shock, Septic - mortality</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demaret, Julie</creatorcontrib><creatorcontrib>Villars-Méchin, Astrid</creatorcontrib><creatorcontrib>Lepape, Alain</creatorcontrib><creatorcontrib>Plassais, Jonathan</creatorcontrib><creatorcontrib>Vallin, Hélène</creatorcontrib><creatorcontrib>Malcus, Christophe</creatorcontrib><creatorcontrib>Poitevin-Later, Françoise</creatorcontrib><creatorcontrib>Monneret, Guillaume</creatorcontrib><creatorcontrib>Venet, Fabienne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demaret, Julie</au><au>Villars-Méchin, Astrid</au><au>Lepape, Alain</au><au>Plassais, Jonathan</au><au>Vallin, Hélène</au><au>Malcus, Christophe</au><au>Poitevin-Later, Françoise</au><au>Monneret, Guillaume</au><au>Venet, Fabienne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients</atitle><jtitle>Intensive care medicine</jtitle><stitle>Intensive Care Med</stitle><addtitle>Intensive Care Med</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>40</volume><issue>8</issue><spage>1089</spage><epage>1096</epage><pages>1089-1096</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><abstract>Purpose
Adjunctive immunoadjuvant therapies are now proposed in the treatment of septic patients that develop immune dysfunctions. However, a prerequisite is to identify patients at high risk of death that would benefit from such therapy. Knowing that rhIL-7 is a putative candidate for septic shock treatment, we evaluated the association between increased plasmatic level of soluble CD127 (sCD127, IL-7 receptor alpha chain) and mortality after septic shock.
Methods
sCD127 plasmatic level was measured in 70 septic shock patients sampled at day 1–2 (D1) and day 3–4 (D3) after the onset of shock and 41 healthy volunteers.
Results
Compared with survivors, non-survivors presented with significantly higher sCD127 concentrations at D1 and D3 (
p
< 0.001 and
p
= 0.002). At D1, the area under the receiver operating characteristic curve for sCD127 level association with mortality was 0.846 (
p
< 0.0001). Kaplan–Meier survival curves illustrated that mortality was significantly different after stratification based on D1 sCD127 level (log rank test, hazard ratio 9.10,
p
< 0.0001). This association was preserved in multivariate logistic regression analysis including clinical confounders (age, SAPS II and SOFA scores, odds ratio 12.71,
p
= 0.003). Importantly, patient stratification on both D1 sCD127 value and SAPS II score improved this predictive capacity (log rank test,
p
= 0.0001).
Conclusions
Increased sCD127 plasmatic level enables the identification of a group of septic shock patients at high risk of death. After confirmation in a larger cohort, this biomarker may be of interest for patient stratification in future clinical trials.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24962718</pmid><doi>10.1007/s00134-014-3346-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0342-4642 |
| ispartof | Intensive care medicine, 2014-08, Vol.40 (8), p.1089-1096 |
| issn | 0342-4642 1432-1238 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1554949917 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Analysis Anesthesiology Biomarkers Biomarkers - blood Clinical trials Critical Care Medicine Cytokines Emergency Medicine Female Hospitals Humans Intensive Intensive care Interleukin-7 Receptor alpha Subunit - blood Male Medicine Medicine & Public Health Middle Aged Mortality Nosocomial infections Original Pain Medicine Patient outcomes Patients Pediatrics Pneumology/Respiratory System Regression Analysis Sepsis Septic shock Shock, Septic - blood Shock, Septic - mortality Viral infections |
| title | Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T21%3A20%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Elevated%20plasmatic%20level%20of%20soluble%20IL-7%20receptor%20is%20associated%20with%20increased%20mortality%20in%20septic%20shock%20patients&rft.jtitle=Intensive%20care%20medicine&rft.au=Demaret,%20Julie&rft.date=2014-08-01&rft.volume=40&rft.issue=8&rft.spage=1089&rft.epage=1096&rft.pages=1089-1096&rft.issn=0342-4642&rft.eissn=1432-1238&rft_id=info:doi/10.1007/s00134-014-3346-0&rft_dat=%3Cgale_proqu%3EA724301323%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1547504066&rft_id=info:pmid/24962718&rft_galeid=A724301323&rfr_iscdi=true |