Acetylcholinesterase Complexes with the Natural Product Inhibitors Dihydrotanshinone I and Territrem B: Binding Site Assignment from Inhibitor Competition and Validation Through Crystal Structure Determination

Acetylcholinesterase (AChE) is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. It is an important target for both therapeutic drugs that treat Alzheimer’s disease and organophosphate (OP) chemical warfare agents th...

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Veröffentlicht in:	Journal of molecular neuroscience 2014-07, Vol.53 (3), p.506-510
Hauptverfasser:	Cheung, Jonah, Beri, Veena, Shiomi, Kazuro, Rosenberry, Terrone L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - chemistry Acetylcholinesterase - metabolism Alzheimer's disease Amino Acid Sequence Animals Binding Sites Biological Products - chemistry Biological Products - pharmacology Biomedical and Life Sciences Biomedicine Cell Biology Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Competition Crystal structure Crystallography Enzymes Humans Ligands Molecular Sequence Data Natural products Nervous system Neurochemistry Neurology Neurosciences Phenanthrenes - chemistry Phenanthrenes - pharmacology Proteomics Pyrans - chemistry Pyrans - pharmacology
Online-Zugang:	Volltext
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