Association of μ-opioid receptor gene (OPRM1) haplotypes with postoperative nausea and vomiting
Genetic variants, such as single-nucleotide polymorphisms (SNPs), of the μ-opioid receptor gene ( OPRM1 ) might be associated with individual differences in opioid sensitivity, as well as with the incidence and severity of postoperative nausea and vomiting (PONV). The goal of the present study was t...
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| Veröffentlicht in: | Experimental brain research 2014-08, Vol.232 (8), p.2627-2635 |
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| creator | Sugino, Shigekazu Hayase, Tomo Higuchi, Misako Saito, Katsuhiko Moriya, Hiroyuki Kumeta, Yukihiro Kurosawa, Nahoko Namiki, Akiyoshi Janicki, Piotr K. |
| description | Genetic variants, such as single-nucleotide polymorphisms (SNPs), of the μ-opioid receptor gene (
OPRM1
) might be associated with individual differences in opioid sensitivity, as well as with the incidence and severity of postoperative nausea and vomiting (PONV). The goal of the present study was to determine, in a cohort of Japanese surgical patients, genotypes and haplotypes of several SNPs in the
OPRM1
gene, and their association with PONV during the early (first 24 h) postoperative period. We examined the incidence and severity of PONV, during the first 24 h after surgery, in 85 Japanese patients receiving intravenous patient-controlled analgesia fentanyl analgesia for postoperative pain control. Eight tag SNPs of the
OPRM1
gene (rs1799971, A/G; rs510769, G/A; rs4870266, G/A; rs3798683, G/A; rs1323042, A/C; rs609623, C/T; rs9397685, A/G; and rs644261, C/G) were selected based on their minor allele frequency (>10 %) and linkage disequilibrium strength (10 % in the investigated patients, including GGGAACAC (33 %), AGGGACAC (19 %), GGGAACGC (12 %), and AGAGACAC (10 %). The severity of PONV in carriers of the GGGAACGC haplotype was significantly lower than in the carriers of the other haplotypes (
P
|
| doi_str_mv | 10.1007/s00221-014-3987-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1554949709</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A380525590</galeid><sourcerecordid>A380525590</sourcerecordid><originalsourceid>FETCH-LOGICAL-c609t-15f0405ab52933b00b78a1bc402266e4ce6eb8bfd8d069c7d22c4d90f798c93c3</originalsourceid><addsrcrecordid>eNqNks1u1DAUhSMEotPCA7BBlhBVu0ixEzuxl6OKn0pFRQXWxnFuMq4ydrCdQt-NZ-CZcJThZySEkBeWfb97LZ9zsuwJwWcE4_pFwLgoSI4JzUvB61zcy1aElkVOCK7uZys8Vygn4iA7DOFmPpY1fpgdFJQzzmqxyj6tQ3DaqGicRa5D37_lbjTOtMiDhjE6j3qwgE6u3l2_Jadoo8bBxbsRAvpi4gaNLkQ3gk8DbgFZNQVQSNkW3bqticb2j7IHnRoCPN7tR9nHVy8_nL_JL69eX5yvL3NdYRFzwjpMMVMNK0RZNhg3NVek0TT9sKqAaqig4U3X8hZXQtdtUWjaCtzVgmtR6vIoO1nmjt59niBEuTVBwzAoC24KkjBGBRU1Fv-BUkE4qWiR0GcL2qsBpLGdi17pGZfrkmNWMCZwos7-QqXVwtZoZ6Ez6X6v4XSvITERvsY-yRfkxfvrffb4D3YDaoib4IZpdizsg2QBtXcheOjk6M1W-TtJsJzzIpe8yBQDOedFzlI83UkxNVtof3X8DEgCnu8AFbQaOq-sNuE3x2uW_JiFKhYupJLtwcsbN3mbHP_H6z8APhrUpg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1549181642</pqid></control><display><type>article</type><title>Association of μ-opioid receptor gene (OPRM1) haplotypes with postoperative nausea and vomiting</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Sugino, Shigekazu ; Hayase, Tomo ; Higuchi, Misako ; Saito, Katsuhiko ; Moriya, Hiroyuki ; Kumeta, Yukihiro ; Kurosawa, Nahoko ; Namiki, Akiyoshi ; Janicki, Piotr K.</creator><creatorcontrib>Sugino, Shigekazu ; Hayase, Tomo ; Higuchi, Misako ; Saito, Katsuhiko ; Moriya, Hiroyuki ; Kumeta, Yukihiro ; Kurosawa, Nahoko ; Namiki, Akiyoshi ; Janicki, Piotr K.</creatorcontrib><description>Genetic variants, such as single-nucleotide polymorphisms (SNPs), of the μ-opioid receptor gene (
OPRM1
) might be associated with individual differences in opioid sensitivity, as well as with the incidence and severity of postoperative nausea and vomiting (PONV). The goal of the present study was to determine, in a cohort of Japanese surgical patients, genotypes and haplotypes of several SNPs in the
OPRM1
gene, and their association with PONV during the early (first 24 h) postoperative period. We examined the incidence and severity of PONV, during the first 24 h after surgery, in 85 Japanese patients receiving intravenous patient-controlled analgesia fentanyl analgesia for postoperative pain control. Eight tag SNPs of the
OPRM1
gene (rs1799971, A/G; rs510769, G/A; rs4870266, G/A; rs3798683, G/A; rs1323042, A/C; rs609623, C/T; rs9397685, A/G; and rs644261, C/G) were selected based on their minor allele frequency (>10 %) and linkage disequilibrium strength (<80 %), and genotyped for haplotype analysis and determination of associations with PONV. Only one out of eight investigated SNPs, rs9397685, in the intronic part of the
OPRM1
gene was associated with differences in the occurrence and severity of PONV. We also found four common haplotypes with a frequency of >10 % in the investigated patients, including GGGAACAC (33 %), AGGGACAC (19 %), GGGAACGC (12 %), and AGAGACAC (10 %). The severity of PONV in carriers of the GGGAACGC haplotype was significantly lower than in the carriers of the other haplotypes (
P
< 0.05). One intronic SNP, rs9397685, and haplotypes constructed from eight SNPs within the
OPRM1
gene locus might be involved in the severity of PONV associated with general anesthesia and opioid administration. This novel finding, if validated and verified in larger and additional ethnic cohorts, might contribute to better knowledge of the contribution of the OPRM1 gene to PONV.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/s00221-014-3987-9</identifier><identifier>PMID: 24858579</identifier><identifier>CODEN: EXBRAP</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis ; Asian Continental Ancestry Group ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genetic Association Studies ; Genotype ; Humans ; Linkage Disequilibrium ; Male ; Middle Aged ; Nausea ; Neurology ; Neurosciences ; Phenotype ; Polymorphism, Single Nucleotide - genetics ; Postoperative Nausea and Vomiting - genetics ; Receptors, Opioid, mu - genetics ; Research Article ; Single nucleotide polymorphisms ; Vertebrates: nervous system and sense organs ; Visual Analog Scale ; Vomiting ; Young Adult</subject><ispartof>Experimental brain research, 2014-08, Vol.232 (8), p.2627-2635</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-15f0405ab52933b00b78a1bc402266e4ce6eb8bfd8d069c7d22c4d90f798c93c3</citedby><cites>FETCH-LOGICAL-c609t-15f0405ab52933b00b78a1bc402266e4ce6eb8bfd8d069c7d22c4d90f798c93c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00221-014-3987-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00221-014-3987-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28750692$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24858579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugino, Shigekazu</creatorcontrib><creatorcontrib>Hayase, Tomo</creatorcontrib><creatorcontrib>Higuchi, Misako</creatorcontrib><creatorcontrib>Saito, Katsuhiko</creatorcontrib><creatorcontrib>Moriya, Hiroyuki</creatorcontrib><creatorcontrib>Kumeta, Yukihiro</creatorcontrib><creatorcontrib>Kurosawa, Nahoko</creatorcontrib><creatorcontrib>Namiki, Akiyoshi</creatorcontrib><creatorcontrib>Janicki, Piotr K.</creatorcontrib><title>Association of μ-opioid receptor gene (OPRM1) haplotypes with postoperative nausea and vomiting</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><addtitle>Exp Brain Res</addtitle><description>Genetic variants, such as single-nucleotide polymorphisms (SNPs), of the μ-opioid receptor gene (
OPRM1
) might be associated with individual differences in opioid sensitivity, as well as with the incidence and severity of postoperative nausea and vomiting (PONV). The goal of the present study was to determine, in a cohort of Japanese surgical patients, genotypes and haplotypes of several SNPs in the
OPRM1
gene, and their association with PONV during the early (first 24 h) postoperative period. We examined the incidence and severity of PONV, during the first 24 h after surgery, in 85 Japanese patients receiving intravenous patient-controlled analgesia fentanyl analgesia for postoperative pain control. Eight tag SNPs of the
OPRM1
gene (rs1799971, A/G; rs510769, G/A; rs4870266, G/A; rs3798683, G/A; rs1323042, A/C; rs609623, C/T; rs9397685, A/G; and rs644261, C/G) were selected based on their minor allele frequency (>10 %) and linkage disequilibrium strength (<80 %), and genotyped for haplotype analysis and determination of associations with PONV. Only one out of eight investigated SNPs, rs9397685, in the intronic part of the
OPRM1
gene was associated with differences in the occurrence and severity of PONV. We also found four common haplotypes with a frequency of >10 % in the investigated patients, including GGGAACAC (33 %), AGGGACAC (19 %), GGGAACGC (12 %), and AGAGACAC (10 %). The severity of PONV in carriers of the GGGAACGC haplotype was significantly lower than in the carriers of the other haplotypes (
P
< 0.05). One intronic SNP, rs9397685, and haplotypes constructed from eight SNPs within the
OPRM1
gene locus might be involved in the severity of PONV associated with general anesthesia and opioid administration. This novel finding, if validated and verified in larger and additional ethnic cohorts, might contribute to better knowledge of the contribution of the OPRM1 gene to PONV.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genotype</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nausea</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Phenotype</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Postoperative Nausea and Vomiting - genetics</subject><subject>Receptors, Opioid, mu - genetics</subject><subject>Research Article</subject><subject>Single nucleotide polymorphisms</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Visual Analog Scale</subject><subject>Vomiting</subject><subject>Young Adult</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAUhSMEotPCA7BBlhBVu0ixEzuxl6OKn0pFRQXWxnFuMq4ydrCdQt-NZ-CZcJThZySEkBeWfb97LZ9zsuwJwWcE4_pFwLgoSI4JzUvB61zcy1aElkVOCK7uZys8Vygn4iA7DOFmPpY1fpgdFJQzzmqxyj6tQ3DaqGicRa5D37_lbjTOtMiDhjE6j3qwgE6u3l2_Jadoo8bBxbsRAvpi4gaNLkQ3gk8DbgFZNQVQSNkW3bqticb2j7IHnRoCPN7tR9nHVy8_nL_JL69eX5yvL3NdYRFzwjpMMVMNK0RZNhg3NVek0TT9sKqAaqig4U3X8hZXQtdtUWjaCtzVgmtR6vIoO1nmjt59niBEuTVBwzAoC24KkjBGBRU1Fv-BUkE4qWiR0GcL2qsBpLGdi17pGZfrkmNWMCZwos7-QqXVwtZoZ6Ez6X6v4XSvITERvsY-yRfkxfvrffb4D3YDaoib4IZpdizsg2QBtXcheOjk6M1W-TtJsJzzIpe8yBQDOedFzlI83UkxNVtof3X8DEgCnu8AFbQaOq-sNuE3x2uW_JiFKhYupJLtwcsbN3mbHP_H6z8APhrUpg</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Sugino, Shigekazu</creator><creator>Hayase, Tomo</creator><creator>Higuchi, Misako</creator><creator>Saito, Katsuhiko</creator><creator>Moriya, Hiroyuki</creator><creator>Kumeta, Yukihiro</creator><creator>Kurosawa, Nahoko</creator><creator>Namiki, Akiyoshi</creator><creator>Janicki, Piotr K.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20140801</creationdate><title>Association of μ-opioid receptor gene (OPRM1) haplotypes with postoperative nausea and vomiting</title><author>Sugino, Shigekazu ; Hayase, Tomo ; Higuchi, Misako ; Saito, Katsuhiko ; Moriya, Hiroyuki ; Kumeta, Yukihiro ; Kurosawa, Nahoko ; Namiki, Akiyoshi ; Janicki, Piotr K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-15f0405ab52933b00b78a1bc402266e4ce6eb8bfd8d069c7d22c4d90f798c93c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Genotype</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nausea</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Phenotype</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Postoperative Nausea and Vomiting - genetics</topic><topic>Receptors, Opioid, mu - genetics</topic><topic>Research Article</topic><topic>Single nucleotide polymorphisms</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Visual Analog Scale</topic><topic>Vomiting</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sugino, Shigekazu</creatorcontrib><creatorcontrib>Hayase, Tomo</creatorcontrib><creatorcontrib>Higuchi, Misako</creatorcontrib><creatorcontrib>Saito, Katsuhiko</creatorcontrib><creatorcontrib>Moriya, Hiroyuki</creatorcontrib><creatorcontrib>Kumeta, Yukihiro</creatorcontrib><creatorcontrib>Kurosawa, Nahoko</creatorcontrib><creatorcontrib>Namiki, Akiyoshi</creatorcontrib><creatorcontrib>Janicki, Piotr K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugino, Shigekazu</au><au>Hayase, Tomo</au><au>Higuchi, Misako</au><au>Saito, Katsuhiko</au><au>Moriya, Hiroyuki</au><au>Kumeta, Yukihiro</au><au>Kurosawa, Nahoko</au><au>Namiki, Akiyoshi</au><au>Janicki, Piotr K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of μ-opioid receptor gene (OPRM1) haplotypes with postoperative nausea and vomiting</atitle><jtitle>Experimental brain research</jtitle><stitle>Exp Brain Res</stitle><addtitle>Exp Brain Res</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>232</volume><issue>8</issue><spage>2627</spage><epage>2635</epage><pages>2627-2635</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>Genetic variants, such as single-nucleotide polymorphisms (SNPs), of the μ-opioid receptor gene (
OPRM1
) might be associated with individual differences in opioid sensitivity, as well as with the incidence and severity of postoperative nausea and vomiting (PONV). The goal of the present study was to determine, in a cohort of Japanese surgical patients, genotypes and haplotypes of several SNPs in the
OPRM1
gene, and their association with PONV during the early (first 24 h) postoperative period. We examined the incidence and severity of PONV, during the first 24 h after surgery, in 85 Japanese patients receiving intravenous patient-controlled analgesia fentanyl analgesia for postoperative pain control. Eight tag SNPs of the
OPRM1
gene (rs1799971, A/G; rs510769, G/A; rs4870266, G/A; rs3798683, G/A; rs1323042, A/C; rs609623, C/T; rs9397685, A/G; and rs644261, C/G) were selected based on their minor allele frequency (>10 %) and linkage disequilibrium strength (<80 %), and genotyped for haplotype analysis and determination of associations with PONV. Only one out of eight investigated SNPs, rs9397685, in the intronic part of the
OPRM1
gene was associated with differences in the occurrence and severity of PONV. We also found four common haplotypes with a frequency of >10 % in the investigated patients, including GGGAACAC (33 %), AGGGACAC (19 %), GGGAACGC (12 %), and AGAGACAC (10 %). The severity of PONV in carriers of the GGGAACGC haplotype was significantly lower than in the carriers of the other haplotypes (
P
< 0.05). One intronic SNP, rs9397685, and haplotypes constructed from eight SNPs within the
OPRM1
gene locus might be involved in the severity of PONV associated with general anesthesia and opioid administration. This novel finding, if validated and verified in larger and additional ethnic cohorts, might contribute to better knowledge of the contribution of the OPRM1 gene to PONV.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24858579</pmid><doi>10.1007/s00221-014-3987-9</doi><tpages>9</tpages></addata></record> |
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| ispartof | Experimental brain research, 2014-08, Vol.232 (8), p.2627-2635 |
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| subjects | Adult Aged Aged, 80 and over Analysis Asian Continental Ancestry Group Biological and medical sciences Biomedical and Life Sciences Biomedicine Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Association Studies Genotype Humans Linkage Disequilibrium Male Middle Aged Nausea Neurology Neurosciences Phenotype Polymorphism, Single Nucleotide - genetics Postoperative Nausea and Vomiting - genetics Receptors, Opioid, mu - genetics Research Article Single nucleotide polymorphisms Vertebrates: nervous system and sense organs Visual Analog Scale Vomiting Young Adult |
| title | Association of μ-opioid receptor gene (OPRM1) haplotypes with postoperative nausea and vomiting |
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