Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications
Philippe Froguel and colleagues report an analysis of large chromosomal clonal mosaic events in individuals with type 2 diabetes. They find a significant association between CME occurrence and T2D with vascular complications. Large chromosomal clonal mosaic events (CMEs) have been suggested to be li...
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| Veröffentlicht in: | Nature genetics 2013-09, Vol.45 (9), p.1040-1043 |
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| creator | Bonnefond, Amélie Skrobek, Boris Lobbens, Stéphane Eury, Elodie Thuillier, Dorothée Cauchi, Stéphane Lantieri, Olivier Balkau, Beverley Riboli, Elio Marre, Michel Charpentier, Guillaume Yengo, Loïc Froguel, Philippe |
| description | Philippe Froguel and colleagues report an analysis of large chromosomal clonal mosaic events in individuals with type 2 diabetes. They find a significant association between CME occurrence and T2D with vascular complications.
Large chromosomal clonal mosaic events (CMEs) have been suggested to be linked to aging
1
,
2
,
3
and to predict cancer
2
,
3
. Type 2 diabetes (T2D) has been conceptualized as an accelerated-aging disease
4
,
5
,
6
and is associated with higher prevalence of cancers
7
,
8
,
9
,
10
,
11
. Here we aimed to assess the association between T2D and CME occurrence in blood. We evaluated the presence of CMEs in 7,659 individuals (including 2,208 with T2D) using DNA arrays. A significant association between CME occurrence and T2D was found (odds ratio (OR) = 5.3;
P
= 5.1 × 10
−5
) and was stronger when we only considered non-obese individuals with T2D (OR = 5.6;
P
= 4.9 × 10
−5
). Notably, CME carriers with T2D had higher prevalence of vascular complications than non-carriers with T2D (71.4% versus 37.1%, respectively;
P
= 7.7 × 10
−4
). In CME carriers, we found an increase in the percentage of abnormal cells over 6 years (
P
= 8.60 × 10
−3
). In conclusion, given the increased risk of cancer in CME carriers
2
,
3
, our results may have profound clinical implications in patients with severe T2D. |
| doi_str_mv | 10.1038/ng.2700 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1554948508</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A345172971</galeid><sourcerecordid>A345172971</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-660f9b1abddf4201fcbf817be434955ecdfa0d1262fcf9a661ccdad2ba45adf83</originalsourceid><addsrcrecordid>eNqN0ktrFTEUB_BBFFur-A0k4EJdzDXJJPNYXoqPQqHgaxvOJCdjykxynWRa--3N2Gq9xUXJIiH5nT_kcIriOaMbRqv2rR82vKH0QXHIpKhL1rD2YT7TmpWCVvVB8STGc0qZELR9XBzwqpU8o8MCtzEG7SC54EmP6RLRkxHmAYnBhDpBPyLRY_AwkilEcNrFiYA3JF3tkHBiHOQ6jOTSpe_kAqJecj3RYdqNTv8Ojk-LRxbGiM9u9qPi6_t3X44_lqdnH06Ot6elloymsq6p7XoGvTFWcMqs7m3Lmh5FJTopURsL1DBec6ttB3XNtDZgeA9CgrFtdVS8vs7dzeHHgjGpyUWN4wgewxIVk1J0opX0HlTwjrOq61imL-_Q87DMuSGrEpKJisn6Vg0wonLehjSDXkPVtsqq4V2zZm3-o_IyODkdPFqX7_cK3uwVZJPwZxpgiVGdfP50f3v2bd--urZ6DjHOaNVudhPMV4pRtc6U8oNaZyrLFzffX_oJzV_3Z4huWxnzkx9w_qc_d7J-AU1O0ZU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1445143156</pqid></control><display><type>article</type><title>Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications</title><source>MEDLINE</source><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Bonnefond, Amélie ; Skrobek, Boris ; Lobbens, Stéphane ; Eury, Elodie ; Thuillier, Dorothée ; Cauchi, Stéphane ; Lantieri, Olivier ; Balkau, Beverley ; Riboli, Elio ; Marre, Michel ; Charpentier, Guillaume ; Yengo, Loïc ; Froguel, Philippe</creator><creatorcontrib>Bonnefond, Amélie ; Skrobek, Boris ; Lobbens, Stéphane ; Eury, Elodie ; Thuillier, Dorothée ; Cauchi, Stéphane ; Lantieri, Olivier ; Balkau, Beverley ; Riboli, Elio ; Marre, Michel ; Charpentier, Guillaume ; Yengo, Loïc ; Froguel, Philippe</creatorcontrib><description>Philippe Froguel and colleagues report an analysis of large chromosomal clonal mosaic events in individuals with type 2 diabetes. They find a significant association between CME occurrence and T2D with vascular complications.
Large chromosomal clonal mosaic events (CMEs) have been suggested to be linked to aging
1
,
2
,
3
and to predict cancer
2
,
3
. Type 2 diabetes (T2D) has been conceptualized as an accelerated-aging disease
4
,
5
,
6
and is associated with higher prevalence of cancers
7
,
8
,
9
,
10
,
11
. Here we aimed to assess the association between T2D and CME occurrence in blood. We evaluated the presence of CMEs in 7,659 individuals (including 2,208 with T2D) using DNA arrays. A significant association between CME occurrence and T2D was found (odds ratio (OR) = 5.3;
P
= 5.1 × 10
−5
) and was stronger when we only considered non-obese individuals with T2D (OR = 5.6;
P
= 4.9 × 10
−5
). Notably, CME carriers with T2D had higher prevalence of vascular complications than non-carriers with T2D (71.4% versus 37.1%, respectively;
P
= 7.7 × 10
−4
). In CME carriers, we found an increase in the percentage of abnormal cells over 6 years (
P
= 8.60 × 10
−3
). In conclusion, given the increased risk of cancer in CME carriers
2
,
3
, our results may have profound clinical implications in patients with severe T2D.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng.2700</identifier><identifier>PMID: 23852171</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/208/1516 ; Age ; Aged ; Agriculture ; Animal Genetics and Genomics ; Biomedicine ; Blood circulation disorders ; Body Mass Index ; Cancer ; Cancer Research ; Case-Control Studies ; Chromosome Aberrations ; Chromosome Mapping ; Complications and side effects ; Confidence intervals ; Deoxyribonucleic acid ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - genetics ; Diabetic Angiopathies - genetics ; DNA ; DNA microarrays ; Family medical history ; Female ; Gene Function ; Genetic aspects ; Genetic Association Studies ; Genetic testing ; Health risks ; Hematology ; Human Genetics ; Humans ; Insulin ; Insulin resistance ; letter ; Male ; Middle Aged ; Mortality ; Mosaicism ; Odds Ratio ; Prospective Studies ; Risk factors ; Sensitivity analysis ; Signal transduction ; Studies ; Type 2 diabetes</subject><ispartof>Nature genetics, 2013-09, Vol.45 (9), p.1040-1043</ispartof><rights>Springer Nature America, Inc. 2013</rights><rights>COPYRIGHT 2013 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-660f9b1abddf4201fcbf817be434955ecdfa0d1262fcf9a661ccdad2ba45adf83</citedby><cites>FETCH-LOGICAL-c510t-660f9b1abddf4201fcbf817be434955ecdfa0d1262fcf9a661ccdad2ba45adf83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23852171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonnefond, Amélie</creatorcontrib><creatorcontrib>Skrobek, Boris</creatorcontrib><creatorcontrib>Lobbens, Stéphane</creatorcontrib><creatorcontrib>Eury, Elodie</creatorcontrib><creatorcontrib>Thuillier, Dorothée</creatorcontrib><creatorcontrib>Cauchi, Stéphane</creatorcontrib><creatorcontrib>Lantieri, Olivier</creatorcontrib><creatorcontrib>Balkau, Beverley</creatorcontrib><creatorcontrib>Riboli, Elio</creatorcontrib><creatorcontrib>Marre, Michel</creatorcontrib><creatorcontrib>Charpentier, Guillaume</creatorcontrib><creatorcontrib>Yengo, Loïc</creatorcontrib><creatorcontrib>Froguel, Philippe</creatorcontrib><title>Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>Philippe Froguel and colleagues report an analysis of large chromosomal clonal mosaic events in individuals with type 2 diabetes. They find a significant association between CME occurrence and T2D with vascular complications.
Large chromosomal clonal mosaic events (CMEs) have been suggested to be linked to aging
1
,
2
,
3
and to predict cancer
2
,
3
. Type 2 diabetes (T2D) has been conceptualized as an accelerated-aging disease
4
,
5
,
6
and is associated with higher prevalence of cancers
7
,
8
,
9
,
10
,
11
. Here we aimed to assess the association between T2D and CME occurrence in blood. We evaluated the presence of CMEs in 7,659 individuals (including 2,208 with T2D) using DNA arrays. A significant association between CME occurrence and T2D was found (odds ratio (OR) = 5.3;
P
= 5.1 × 10
−5
) and was stronger when we only considered non-obese individuals with T2D (OR = 5.6;
P
= 4.9 × 10
−5
). Notably, CME carriers with T2D had higher prevalence of vascular complications than non-carriers with T2D (71.4% versus 37.1%, respectively;
P
= 7.7 × 10
−4
). In CME carriers, we found an increase in the percentage of abnormal cells over 6 years (
P
= 8.60 × 10
−3
). In conclusion, given the increased risk of cancer in CME carriers
2
,
3
, our results may have profound clinical implications in patients with severe T2D.</description><subject>631/208/1516</subject><subject>Age</subject><subject>Aged</subject><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Biomedicine</subject><subject>Blood circulation disorders</subject><subject>Body Mass Index</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Chromosome Aberrations</subject><subject>Chromosome Mapping</subject><subject>Complications and side effects</subject><subject>Confidence intervals</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetic Angiopathies - genetics</subject><subject>DNA</subject><subject>DNA microarrays</subject><subject>Family medical history</subject><subject>Female</subject><subject>Gene Function</subject><subject>Genetic aspects</subject><subject>Genetic Association Studies</subject><subject>Genetic testing</subject><subject>Health risks</subject><subject>Hematology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>letter</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Mosaicism</subject><subject>Odds Ratio</subject><subject>Prospective Studies</subject><subject>Risk factors</subject><subject>Sensitivity analysis</subject><subject>Signal transduction</subject><subject>Studies</subject><subject>Type 2 diabetes</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0ktrFTEUB_BBFFur-A0k4EJdzDXJJPNYXoqPQqHgaxvOJCdjykxynWRa--3N2Gq9xUXJIiH5nT_kcIriOaMbRqv2rR82vKH0QXHIpKhL1rD2YT7TmpWCVvVB8STGc0qZELR9XBzwqpU8o8MCtzEG7SC54EmP6RLRkxHmAYnBhDpBPyLRY_AwkilEcNrFiYA3JF3tkHBiHOQ6jOTSpe_kAqJecj3RYdqNTv8Ojk-LRxbGiM9u9qPi6_t3X44_lqdnH06Ot6elloymsq6p7XoGvTFWcMqs7m3Lmh5FJTopURsL1DBec6ttB3XNtDZgeA9CgrFtdVS8vs7dzeHHgjGpyUWN4wgewxIVk1J0opX0HlTwjrOq61imL-_Q87DMuSGrEpKJisn6Vg0wonLehjSDXkPVtsqq4V2zZm3-o_IyODkdPFqX7_cK3uwVZJPwZxpgiVGdfP50f3v2bd--urZ6DjHOaNVudhPMV4pRtc6U8oNaZyrLFzffX_oJzV_3Z4huWxnzkx9w_qc_d7J-AU1O0ZU</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Bonnefond, 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between large detectable clonal mosaicism and type 2 diabetes with vascular complications</title><author>Bonnefond, Amélie ; Skrobek, Boris ; Lobbens, Stéphane ; Eury, Elodie ; Thuillier, Dorothée ; Cauchi, Stéphane ; Lantieri, Olivier ; Balkau, Beverley ; Riboli, Elio ; Marre, Michel ; Charpentier, Guillaume ; Yengo, Loïc ; Froguel, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-660f9b1abddf4201fcbf817be434955ecdfa0d1262fcf9a661ccdad2ba45adf83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>631/208/1516</topic><topic>Age</topic><topic>Aged</topic><topic>Agriculture</topic><topic>Animal Genetics and Genomics</topic><topic>Biomedicine</topic><topic>Blood circulation disorders</topic><topic>Body Mass Index</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Chromosome Aberrations</topic><topic>Chromosome Mapping</topic><topic>Complications and side effects</topic><topic>Confidence intervals</topic><topic>Deoxyribonucleic acid</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetic Angiopathies - genetics</topic><topic>DNA</topic><topic>DNA microarrays</topic><topic>Family medical history</topic><topic>Female</topic><topic>Gene Function</topic><topic>Genetic aspects</topic><topic>Genetic Association Studies</topic><topic>Genetic testing</topic><topic>Health risks</topic><topic>Hematology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>letter</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Mosaicism</topic><topic>Odds Ratio</topic><topic>Prospective Studies</topic><topic>Risk factors</topic><topic>Sensitivity analysis</topic><topic>Signal transduction</topic><topic>Studies</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonnefond, Amélie</creatorcontrib><creatorcontrib>Skrobek, Boris</creatorcontrib><creatorcontrib>Lobbens, Stéphane</creatorcontrib><creatorcontrib>Eury, Elodie</creatorcontrib><creatorcontrib>Thuillier, Dorothée</creatorcontrib><creatorcontrib>Cauchi, Stéphane</creatorcontrib><creatorcontrib>Lantieri, Olivier</creatorcontrib><creatorcontrib>Balkau, Beverley</creatorcontrib><creatorcontrib>Riboli, Elio</creatorcontrib><creatorcontrib>Marre, Michel</creatorcontrib><creatorcontrib>Charpentier, Guillaume</creatorcontrib><creatorcontrib>Yengo, Loïc</creatorcontrib><creatorcontrib>Froguel, Philippe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing 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Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonnefond, Amélie</au><au>Skrobek, Boris</au><au>Lobbens, Stéphane</au><au>Eury, Elodie</au><au>Thuillier, Dorothée</au><au>Cauchi, Stéphane</au><au>Lantieri, Olivier</au><au>Balkau, Beverley</au><au>Riboli, Elio</au><au>Marre, Michel</au><au>Charpentier, Guillaume</au><au>Yengo, Loïc</au><au>Froguel, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>45</volume><issue>9</issue><spage>1040</spage><epage>1043</epage><pages>1040-1043</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><abstract>Philippe Froguel and colleagues report an analysis of large chromosomal clonal mosaic events in individuals with type 2 diabetes. They find a significant association between CME occurrence and T2D with vascular complications.
Large chromosomal clonal mosaic events (CMEs) have been suggested to be linked to aging
1
,
2
,
3
and to predict cancer
2
,
3
. Type 2 diabetes (T2D) has been conceptualized as an accelerated-aging disease
4
,
5
,
6
and is associated with higher prevalence of cancers
7
,
8
,
9
,
10
,
11
. Here we aimed to assess the association between T2D and CME occurrence in blood. We evaluated the presence of CMEs in 7,659 individuals (including 2,208 with T2D) using DNA arrays. A significant association between CME occurrence and T2D was found (odds ratio (OR) = 5.3;
P
= 5.1 × 10
−5
) and was stronger when we only considered non-obese individuals with T2D (OR = 5.6;
P
= 4.9 × 10
−5
). Notably, CME carriers with T2D had higher prevalence of vascular complications than non-carriers with T2D (71.4% versus 37.1%, respectively;
P
= 7.7 × 10
−4
). In CME carriers, we found an increase in the percentage of abnormal cells over 6 years (
P
= 8.60 × 10
−3
). In conclusion, given the increased risk of cancer in CME carriers
2
,
3
, our results may have profound clinical implications in patients with severe T2D.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>23852171</pmid><doi>10.1038/ng.2700</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Nature genetics, 2013-09, Vol.45 (9), p.1040-1043 |
| issn | 1061-4036 1546-1718 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1554948508 |
| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | 631/208/1516 Age Aged Agriculture Animal Genetics and Genomics Biomedicine Blood circulation disorders Body Mass Index Cancer Cancer Research Case-Control Studies Chromosome Aberrations Chromosome Mapping Complications and side effects Confidence intervals Deoxyribonucleic acid Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetic Angiopathies - genetics DNA DNA microarrays Family medical history Female Gene Function Genetic aspects Genetic Association Studies Genetic testing Health risks Hematology Human Genetics Humans Insulin Insulin resistance letter Male Middle Aged Mortality Mosaicism Odds Ratio Prospective Studies Risk factors Sensitivity analysis Signal transduction Studies Type 2 diabetes |
| title | Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications |
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