Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: The Genes-environments & Admixture in Latino Americans study
Background Asthma is a complex disease with both genetic and environmental causes. Genome-wide association studies of asthma have mostly involved European populations, and replication of positive associations has been inconsistent. Objective We sought to identify asthma-associated genes in a large L...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2014-08, Vol.134 (2), p.295-305 |
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| creator | Galanter, Joshua M., MD, MAS Gignoux, Christopher R., MS Torgerson, Dara G., PhD Roth, Lindsey A., MA Eng, Celeste, BS Oh, Sam S., MPH, PhD Nguyen, Elizabeth A., BS Drake, Katherine A., PhD Huntsman, Scott, MS Hu, Donglei, PhD Sen, Saunak, PhD Davis, Adam, MA, MPH Farber, Harold J., MD, MSPH Avila, Pedro C., MD Brigino-Buenaventura, Emerita, MD LeNoir, Michael A., MD Meade, Kelley, MD Serebrisky, Denise, MD Borrell, Luisa N., DDS, PhD Rodríguez-Cintrón, William, MD Estrada, Andres Moreno, MD, PhD Mendoza, Karla Sandoval, MS, PhD Winkler, Cheryl A., PhD Klitz, William, PhD Romieu, Isabelle, MD, MPH London, Stephanie J., MD, DrPh Gilliland, Frank, MD, PhD Martinez, Fernando, MD Bustamante, Carlos, MA, PhD Williams, L. Keoki, MD, MPH Kumar, Rajesh, MD Rodríguez-Santana, José R., MD Burchard, Esteban G., MD, MPH |
| description | Background Asthma is a complex disease with both genetic and environmental causes. Genome-wide association studies of asthma have mostly involved European populations, and replication of positive associations has been inconsistent. Objective We sought to identify asthma-associated genes in a large Latino population with genome-wide association analysis and admixture mapping. Methods Latino children with asthma (n = 1893) and healthy control subjects (n = 1881) were recruited from 5 sites in the United States: Puerto Rico, New York, Chicago, Houston, and the San Francisco Bay Area. Subjects were genotyped on an Affymetrix World Array IV chip. We performed genome-wide association and admixture mapping to identify asthma-associated loci. Results We identified a significant association between ancestry and asthma at 6p21 (lowest P value: rs2523924, P < 5 × 10−6 ). This association replicates in a meta-analysis of the EVE Asthma Consortium ( P = .01). Fine mapping of the region in this study and the EVE Asthma Consortium suggests an association between PSORS1C1 and asthma. We confirmed the strong allelic association between SNPs in the 17q21 region and asthma in Latinos ( IKZF3 , lowest P value: rs90792, odds ratio, 0.67; 95% CI, 0.61-0.75; P = 6 × 10−13 ) and replicated associations in several genes that had previously been associated with asthma in genome-wide association studies. Conclusions Admixture mapping and genome-wide association are complementary techniques that provide evidence for multiple asthma-associated loci in Latinos. Admixture mapping identifies a novel locus on 6p21 that replicates in a meta-analysis of several Latino populations, whereas genome-wide association confirms the previously identified locus on 17q21. |
| doi_str_mv | 10.1016/j.jaci.2013.08.055 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1554946439</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S009167491301765X</els_id><sourcerecordid>3388903411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c685t-fc8e151430398d43cdf96f6215aa2827e61afb90fb0259a58c655855f3cf60e63</originalsourceid><addsrcrecordid>eNqNkt9qFDEUxgdR7Fp9AS8kIIg3MyaTP5OICEvRKix4YQXvQjY5sVlnMttkprov5HOaZdsVeiG9Sg78vu_k5HxV9ZzghmAi3myajbGhaTGhDZYN5vxBtSBYdbWQLX9YLTBWpBYdUyfVk5w3uNRUqsfVScsYFriji-rPOcRxgPpXcIBMzqMNZgpjRHma3Q6Z6JBxQ_g9zQnQYLbbEH-gwsYp-B1ywXtIpSjS6XIw9a0DONSXCwoRrYpfHPNbdHEJqHSDXEO8DmmMQxFm9Aotjw2OOFoOkII1MR8e8rR65E2f4dnNeVp9-_jh4uxTvfpy_vlsuaqtkHyqvZVAOGEUUyUdo9Z5JbxoCTemlW0Hghi_VtivccuV4dIKziXnnlovMAh6Wr0--G7TeDVDnvQQsoW-NxHGOWvCOVNMMKrugxLaKibZPVBStsQ6TAv68g66GecUy8yFYkpxhrEsVHugbBpzTuD1NoXBpJ0mWO-zoTd6nw29z4bGUpdsFNGLG-t5PYA7Sm7DUIB3BwDKD18HSDrbANGCCwnspN0Y_u___o7c9iGWJfY_YQf53xw6txrrr_t07sNJKCad4N_pX_KI4LQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1549954008</pqid></control><display><type>article</type><title>Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: The Genes-environments & Admixture in Latino Americans study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Galanter, Joshua M., MD, MAS ; Gignoux, Christopher R., MS ; Torgerson, Dara G., PhD ; Roth, Lindsey A., MA ; Eng, Celeste, BS ; Oh, Sam S., MPH, PhD ; Nguyen, Elizabeth A., BS ; Drake, Katherine A., PhD ; Huntsman, Scott, MS ; Hu, Donglei, PhD ; Sen, Saunak, PhD ; Davis, Adam, MA, MPH ; Farber, Harold J., MD, MSPH ; Avila, Pedro C., MD ; Brigino-Buenaventura, Emerita, MD ; LeNoir, Michael A., MD ; Meade, Kelley, MD ; Serebrisky, Denise, MD ; Borrell, Luisa N., DDS, PhD ; Rodríguez-Cintrón, William, MD ; Estrada, Andres Moreno, MD, PhD ; Mendoza, Karla Sandoval, MS, PhD ; Winkler, Cheryl A., PhD ; Klitz, William, PhD ; Romieu, Isabelle, MD, MPH ; London, Stephanie J., MD, DrPh ; Gilliland, Frank, MD, PhD ; Martinez, Fernando, MD ; Bustamante, Carlos, MA, PhD ; Williams, L. Keoki, MD, MPH ; Kumar, Rajesh, MD ; Rodríguez-Santana, José R., MD ; Burchard, Esteban G., MD, MPH</creator><creatorcontrib>Galanter, Joshua M., MD, MAS ; Gignoux, Christopher R., MS ; Torgerson, Dara G., PhD ; Roth, Lindsey A., MA ; Eng, Celeste, BS ; Oh, Sam S., MPH, PhD ; Nguyen, Elizabeth A., BS ; Drake, Katherine A., PhD ; Huntsman, Scott, MS ; Hu, Donglei, PhD ; Sen, Saunak, PhD ; Davis, Adam, MA, MPH ; Farber, Harold J., MD, MSPH ; Avila, Pedro C., MD ; Brigino-Buenaventura, Emerita, MD ; LeNoir, Michael A., MD ; Meade, Kelley, MD ; Serebrisky, Denise, MD ; Borrell, Luisa N., DDS, PhD ; Rodríguez-Cintrón, William, MD ; Estrada, Andres Moreno, MD, PhD ; Mendoza, Karla Sandoval, MS, PhD ; Winkler, Cheryl A., PhD ; Klitz, William, PhD ; Romieu, Isabelle, MD, MPH ; London, Stephanie J., MD, DrPh ; Gilliland, Frank, MD, PhD ; Martinez, Fernando, MD ; Bustamante, Carlos, MA, PhD ; Williams, L. Keoki, MD, MPH ; Kumar, Rajesh, MD ; Rodríguez-Santana, José R., MD ; Burchard, Esteban G., MD, MPH</creatorcontrib><description>Background Asthma is a complex disease with both genetic and environmental causes. Genome-wide association studies of asthma have mostly involved European populations, and replication of positive associations has been inconsistent. Objective We sought to identify asthma-associated genes in a large Latino population with genome-wide association analysis and admixture mapping. Methods Latino children with asthma (n = 1893) and healthy control subjects (n = 1881) were recruited from 5 sites in the United States: Puerto Rico, New York, Chicago, Houston, and the San Francisco Bay Area. Subjects were genotyped on an Affymetrix World Array IV chip. We performed genome-wide association and admixture mapping to identify asthma-associated loci. Results We identified a significant association between ancestry and asthma at 6p21 (lowest P value: rs2523924, P < 5 × 10−6 ). This association replicates in a meta-analysis of the EVE Asthma Consortium ( P = .01). Fine mapping of the region in this study and the EVE Asthma Consortium suggests an association between PSORS1C1 and asthma. We confirmed the strong allelic association between SNPs in the 17q21 region and asthma in Latinos ( IKZF3 , lowest P value: rs90792, odds ratio, 0.67; 95% CI, 0.61-0.75; P = 6 × 10−13 ) and replicated associations in several genes that had previously been associated with asthma in genome-wide association studies. Conclusions Admixture mapping and genome-wide association are complementary techniques that provide evidence for multiple asthma-associated loci in Latinos. Admixture mapping identifies a novel locus on 6p21 that replicates in a meta-analysis of several Latino populations, whereas genome-wide association confirms the previously identified locus on 17q21.</description><identifier>ISSN: 0091-6749</identifier><identifier>ISSN: 1097-6825</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2013.08.055</identifier><identifier>PMID: 24406073</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>17q21 ; 6p21 ; admixture mapping ; Adolescent ; African Americans ; Allergy and Immunology ; Asthma ; Asthma - diagnosis ; Asthma - ethnology ; Asthma - genetics ; Child ; Chromosome Mapping ; Chromosomes, Human, Pair 17 ; Chromosomes, Human, Pair 6 ; Chronic illnesses ; Disease ; Estimates ; Female ; Genealogy ; Genetic Loci ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genomes ; Hispanic or Latino ; Humans ; Ikaros Transcription Factor - genetics ; Latinos ; local ancestry ; Male ; Polymorphism, Single Nucleotide ; Proteins - genetics ; Statistical methods ; Studies ; United States ; Young Adult</subject><ispartof>Journal of allergy and clinical immunology, 2014-08, Vol.134 (2), p.295-305</ispartof><rights>2014</rights><rights>Published by Mosby, Inc.</rights><rights>Copyright Elsevier Limited Aug 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c685t-fc8e151430398d43cdf96f6215aa2827e61afb90fb0259a58c655855f3cf60e63</citedby><cites>FETCH-LOGICAL-c685t-fc8e151430398d43cdf96f6215aa2827e61afb90fb0259a58c655855f3cf60e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S009167491301765X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24406073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Galanter, Joshua M., MD, MAS</creatorcontrib><creatorcontrib>Gignoux, Christopher R., MS</creatorcontrib><creatorcontrib>Torgerson, Dara G., PhD</creatorcontrib><creatorcontrib>Roth, Lindsey A., MA</creatorcontrib><creatorcontrib>Eng, Celeste, BS</creatorcontrib><creatorcontrib>Oh, Sam S., MPH, PhD</creatorcontrib><creatorcontrib>Nguyen, Elizabeth A., BS</creatorcontrib><creatorcontrib>Drake, Katherine A., PhD</creatorcontrib><creatorcontrib>Huntsman, Scott, MS</creatorcontrib><creatorcontrib>Hu, Donglei, PhD</creatorcontrib><creatorcontrib>Sen, Saunak, PhD</creatorcontrib><creatorcontrib>Davis, Adam, MA, MPH</creatorcontrib><creatorcontrib>Farber, Harold J., MD, MSPH</creatorcontrib><creatorcontrib>Avila, Pedro C., MD</creatorcontrib><creatorcontrib>Brigino-Buenaventura, Emerita, MD</creatorcontrib><creatorcontrib>LeNoir, Michael A., MD</creatorcontrib><creatorcontrib>Meade, Kelley, MD</creatorcontrib><creatorcontrib>Serebrisky, Denise, MD</creatorcontrib><creatorcontrib>Borrell, Luisa N., DDS, PhD</creatorcontrib><creatorcontrib>Rodríguez-Cintrón, William, MD</creatorcontrib><creatorcontrib>Estrada, Andres Moreno, MD, PhD</creatorcontrib><creatorcontrib>Mendoza, Karla Sandoval, MS, PhD</creatorcontrib><creatorcontrib>Winkler, Cheryl A., PhD</creatorcontrib><creatorcontrib>Klitz, William, PhD</creatorcontrib><creatorcontrib>Romieu, Isabelle, MD, MPH</creatorcontrib><creatorcontrib>London, Stephanie J., MD, DrPh</creatorcontrib><creatorcontrib>Gilliland, Frank, MD, PhD</creatorcontrib><creatorcontrib>Martinez, Fernando, MD</creatorcontrib><creatorcontrib>Bustamante, Carlos, MA, PhD</creatorcontrib><creatorcontrib>Williams, L. Keoki, MD, MPH</creatorcontrib><creatorcontrib>Kumar, Rajesh, MD</creatorcontrib><creatorcontrib>Rodríguez-Santana, José R., MD</creatorcontrib><creatorcontrib>Burchard, Esteban G., MD, MPH</creatorcontrib><title>Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: The Genes-environments & Admixture in Latino Americans study</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background Asthma is a complex disease with both genetic and environmental causes. Genome-wide association studies of asthma have mostly involved European populations, and replication of positive associations has been inconsistent. Objective We sought to identify asthma-associated genes in a large Latino population with genome-wide association analysis and admixture mapping. Methods Latino children with asthma (n = 1893) and healthy control subjects (n = 1881) were recruited from 5 sites in the United States: Puerto Rico, New York, Chicago, Houston, and the San Francisco Bay Area. Subjects were genotyped on an Affymetrix World Array IV chip. We performed genome-wide association and admixture mapping to identify asthma-associated loci. Results We identified a significant association between ancestry and asthma at 6p21 (lowest P value: rs2523924, P < 5 × 10−6 ). This association replicates in a meta-analysis of the EVE Asthma Consortium ( P = .01). Fine mapping of the region in this study and the EVE Asthma Consortium suggests an association between PSORS1C1 and asthma. We confirmed the strong allelic association between SNPs in the 17q21 region and asthma in Latinos ( IKZF3 , lowest P value: rs90792, odds ratio, 0.67; 95% CI, 0.61-0.75; P = 6 × 10−13 ) and replicated associations in several genes that had previously been associated with asthma in genome-wide association studies. Conclusions Admixture mapping and genome-wide association are complementary techniques that provide evidence for multiple asthma-associated loci in Latinos. Admixture mapping identifies a novel locus on 6p21 that replicates in a meta-analysis of several Latino populations, whereas genome-wide association confirms the previously identified locus on 17q21.</description><subject>17q21</subject><subject>6p21</subject><subject>admixture mapping</subject><subject>Adolescent</subject><subject>African Americans</subject><subject>Allergy and Immunology</subject><subject>Asthma</subject><subject>Asthma - diagnosis</subject><subject>Asthma - ethnology</subject><subject>Asthma - genetics</subject><subject>Child</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 17</subject><subject>Chromosomes, Human, Pair 6</subject><subject>Chronic illnesses</subject><subject>Disease</subject><subject>Estimates</subject><subject>Female</subject><subject>Genealogy</subject><subject>Genetic Loci</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Hispanic or Latino</subject><subject>Humans</subject><subject>Ikaros Transcription Factor - genetics</subject><subject>Latinos</subject><subject>local ancestry</subject><subject>Male</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteins - genetics</subject><subject>Statistical methods</subject><subject>Studies</subject><subject>United States</subject><subject>Young Adult</subject><issn>0091-6749</issn><issn>1097-6825</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt9qFDEUxgdR7Fp9AS8kIIg3MyaTP5OICEvRKix4YQXvQjY5sVlnMttkprov5HOaZdsVeiG9Sg78vu_k5HxV9ZzghmAi3myajbGhaTGhDZYN5vxBtSBYdbWQLX9YLTBWpBYdUyfVk5w3uNRUqsfVScsYFriji-rPOcRxgPpXcIBMzqMNZgpjRHma3Q6Z6JBxQ_g9zQnQYLbbEH-gwsYp-B1ywXtIpSjS6XIw9a0DONSXCwoRrYpfHPNbdHEJqHSDXEO8DmmMQxFm9Aotjw2OOFoOkII1MR8e8rR65E2f4dnNeVp9-_jh4uxTvfpy_vlsuaqtkHyqvZVAOGEUUyUdo9Z5JbxoCTemlW0Hghi_VtivccuV4dIKziXnnlovMAh6Wr0--G7TeDVDnvQQsoW-NxHGOWvCOVNMMKrugxLaKibZPVBStsQ6TAv68g66GecUy8yFYkpxhrEsVHugbBpzTuD1NoXBpJ0mWO-zoTd6nw29z4bGUpdsFNGLG-t5PYA7Sm7DUIB3BwDKD18HSDrbANGCCwnspN0Y_u___o7c9iGWJfY_YQf53xw6txrrr_t07sNJKCad4N_pX_KI4LQ</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Galanter, Joshua M., MD, MAS</creator><creator>Gignoux, Christopher R., MS</creator><creator>Torgerson, Dara G., PhD</creator><creator>Roth, Lindsey A., MA</creator><creator>Eng, Celeste, BS</creator><creator>Oh, Sam S., MPH, PhD</creator><creator>Nguyen, Elizabeth A., BS</creator><creator>Drake, Katherine A., PhD</creator><creator>Huntsman, Scott, MS</creator><creator>Hu, Donglei, PhD</creator><creator>Sen, Saunak, PhD</creator><creator>Davis, Adam, MA, MPH</creator><creator>Farber, Harold J., MD, MSPH</creator><creator>Avila, Pedro C., MD</creator><creator>Brigino-Buenaventura, Emerita, MD</creator><creator>LeNoir, Michael A., MD</creator><creator>Meade, Kelley, MD</creator><creator>Serebrisky, Denise, MD</creator><creator>Borrell, Luisa N., DDS, PhD</creator><creator>Rodríguez-Cintrón, William, MD</creator><creator>Estrada, Andres Moreno, MD, PhD</creator><creator>Mendoza, Karla Sandoval, MS, PhD</creator><creator>Winkler, Cheryl A., PhD</creator><creator>Klitz, William, PhD</creator><creator>Romieu, Isabelle, MD, MPH</creator><creator>London, Stephanie J., MD, DrPh</creator><creator>Gilliland, Frank, MD, PhD</creator><creator>Martinez, Fernando, MD</creator><creator>Bustamante, Carlos, MA, PhD</creator><creator>Williams, L. Keoki, MD, MPH</creator><creator>Kumar, Rajesh, MD</creator><creator>Rodríguez-Santana, José R., MD</creator><creator>Burchard, Esteban G., MD, MPH</creator><general>Mosby, Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20140801</creationdate><title>Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: The Genes-environments & Admixture in Latino Americans study</title><author>Galanter, Joshua M., MD, MAS ; Gignoux, Christopher R., MS ; Torgerson, Dara G., PhD ; Roth, Lindsey A., MA ; Eng, Celeste, BS ; Oh, Sam S., MPH, PhD ; Nguyen, Elizabeth A., BS ; Drake, Katherine A., PhD ; Huntsman, Scott, MS ; Hu, Donglei, PhD ; Sen, Saunak, PhD ; Davis, Adam, MA, MPH ; Farber, Harold J., MD, MSPH ; Avila, Pedro C., MD ; Brigino-Buenaventura, Emerita, MD ; LeNoir, Michael A., MD ; Meade, Kelley, MD ; Serebrisky, Denise, MD ; Borrell, Luisa N., DDS, PhD ; Rodríguez-Cintrón, William, MD ; Estrada, Andres Moreno, MD, PhD ; Mendoza, Karla Sandoval, MS, PhD ; Winkler, Cheryl A., PhD ; Klitz, William, PhD ; Romieu, Isabelle, MD, MPH ; London, Stephanie J., MD, DrPh ; Gilliland, Frank, MD, PhD ; Martinez, Fernando, MD ; Bustamante, Carlos, MA, PhD ; Williams, L. Keoki, MD, MPH ; Kumar, Rajesh, MD ; Rodríguez-Santana, José R., MD ; Burchard, Esteban G., MD, MPH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c685t-fc8e151430398d43cdf96f6215aa2827e61afb90fb0259a58c655855f3cf60e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>17q21</topic><topic>6p21</topic><topic>admixture mapping</topic><topic>Adolescent</topic><topic>African Americans</topic><topic>Allergy and Immunology</topic><topic>Asthma</topic><topic>Asthma - diagnosis</topic><topic>Asthma - ethnology</topic><topic>Asthma - genetics</topic><topic>Child</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 17</topic><topic>Chromosomes, Human, Pair 6</topic><topic>Chronic illnesses</topic><topic>Disease</topic><topic>Estimates</topic><topic>Female</topic><topic>Genealogy</topic><topic>Genetic Loci</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Hispanic or Latino</topic><topic>Humans</topic><topic>Ikaros Transcription Factor - genetics</topic><topic>Latinos</topic><topic>local ancestry</topic><topic>Male</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proteins - genetics</topic><topic>Statistical methods</topic><topic>Studies</topic><topic>United States</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galanter, Joshua M., MD, MAS</creatorcontrib><creatorcontrib>Gignoux, Christopher R., MS</creatorcontrib><creatorcontrib>Torgerson, Dara G., PhD</creatorcontrib><creatorcontrib>Roth, Lindsey A., MA</creatorcontrib><creatorcontrib>Eng, Celeste, BS</creatorcontrib><creatorcontrib>Oh, Sam S., MPH, PhD</creatorcontrib><creatorcontrib>Nguyen, Elizabeth A., BS</creatorcontrib><creatorcontrib>Drake, Katherine A., PhD</creatorcontrib><creatorcontrib>Huntsman, Scott, MS</creatorcontrib><creatorcontrib>Hu, Donglei, PhD</creatorcontrib><creatorcontrib>Sen, Saunak, PhD</creatorcontrib><creatorcontrib>Davis, Adam, MA, MPH</creatorcontrib><creatorcontrib>Farber, Harold J., MD, MSPH</creatorcontrib><creatorcontrib>Avila, Pedro C., MD</creatorcontrib><creatorcontrib>Brigino-Buenaventura, Emerita, MD</creatorcontrib><creatorcontrib>LeNoir, Michael A., MD</creatorcontrib><creatorcontrib>Meade, Kelley, MD</creatorcontrib><creatorcontrib>Serebrisky, Denise, MD</creatorcontrib><creatorcontrib>Borrell, Luisa N., DDS, PhD</creatorcontrib><creatorcontrib>Rodríguez-Cintrón, William, MD</creatorcontrib><creatorcontrib>Estrada, Andres Moreno, MD, PhD</creatorcontrib><creatorcontrib>Mendoza, Karla Sandoval, MS, PhD</creatorcontrib><creatorcontrib>Winkler, Cheryl A., PhD</creatorcontrib><creatorcontrib>Klitz, William, PhD</creatorcontrib><creatorcontrib>Romieu, Isabelle, MD, MPH</creatorcontrib><creatorcontrib>London, Stephanie J., MD, DrPh</creatorcontrib><creatorcontrib>Gilliland, Frank, MD, PhD</creatorcontrib><creatorcontrib>Martinez, Fernando, MD</creatorcontrib><creatorcontrib>Bustamante, Carlos, MA, PhD</creatorcontrib><creatorcontrib>Williams, L. Keoki, MD, MPH</creatorcontrib><creatorcontrib>Kumar, Rajesh, MD</creatorcontrib><creatorcontrib>Rodríguez-Santana, José R., MD</creatorcontrib><creatorcontrib>Burchard, Esteban G., MD, MPH</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galanter, Joshua M., MD, MAS</au><au>Gignoux, Christopher R., MS</au><au>Torgerson, Dara G., PhD</au><au>Roth, Lindsey A., MA</au><au>Eng, Celeste, BS</au><au>Oh, Sam S., MPH, PhD</au><au>Nguyen, Elizabeth A., BS</au><au>Drake, Katherine A., PhD</au><au>Huntsman, Scott, MS</au><au>Hu, Donglei, PhD</au><au>Sen, Saunak, PhD</au><au>Davis, Adam, MA, MPH</au><au>Farber, Harold J., MD, MSPH</au><au>Avila, Pedro C., MD</au><au>Brigino-Buenaventura, Emerita, MD</au><au>LeNoir, Michael A., MD</au><au>Meade, Kelley, MD</au><au>Serebrisky, Denise, MD</au><au>Borrell, Luisa N., DDS, PhD</au><au>Rodríguez-Cintrón, William, MD</au><au>Estrada, Andres Moreno, MD, PhD</au><au>Mendoza, Karla Sandoval, MS, PhD</au><au>Winkler, Cheryl A., PhD</au><au>Klitz, William, PhD</au><au>Romieu, Isabelle, MD, MPH</au><au>London, Stephanie J., MD, DrPh</au><au>Gilliland, Frank, MD, PhD</au><au>Martinez, Fernando, MD</au><au>Bustamante, Carlos, MA, PhD</au><au>Williams, L. Keoki, MD, MPH</au><au>Kumar, Rajesh, MD</au><au>Rodríguez-Santana, José R., MD</au><au>Burchard, Esteban G., MD, MPH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: The Genes-environments & Admixture in Latino Americans study</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>134</volume><issue>2</issue><spage>295</spage><epage>305</epage><pages>295-305</pages><issn>0091-6749</issn><issn>1097-6825</issn><eissn>1097-6825</eissn><abstract>Background Asthma is a complex disease with both genetic and environmental causes. Genome-wide association studies of asthma have mostly involved European populations, and replication of positive associations has been inconsistent. Objective We sought to identify asthma-associated genes in a large Latino population with genome-wide association analysis and admixture mapping. Methods Latino children with asthma (n = 1893) and healthy control subjects (n = 1881) were recruited from 5 sites in the United States: Puerto Rico, New York, Chicago, Houston, and the San Francisco Bay Area. Subjects were genotyped on an Affymetrix World Array IV chip. We performed genome-wide association and admixture mapping to identify asthma-associated loci. Results We identified a significant association between ancestry and asthma at 6p21 (lowest P value: rs2523924, P < 5 × 10−6 ). This association replicates in a meta-analysis of the EVE Asthma Consortium ( P = .01). Fine mapping of the region in this study and the EVE Asthma Consortium suggests an association between PSORS1C1 and asthma. We confirmed the strong allelic association between SNPs in the 17q21 region and asthma in Latinos ( IKZF3 , lowest P value: rs90792, odds ratio, 0.67; 95% CI, 0.61-0.75; P = 6 × 10−13 ) and replicated associations in several genes that had previously been associated with asthma in genome-wide association studies. Conclusions Admixture mapping and genome-wide association are complementary techniques that provide evidence for multiple asthma-associated loci in Latinos. Admixture mapping identifies a novel locus on 6p21 that replicates in a meta-analysis of several Latino populations, whereas genome-wide association confirms the previously identified locus on 17q21.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>24406073</pmid><doi>10.1016/j.jaci.2013.08.055</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 2014-08, Vol.134 (2), p.295-305 |
| issn | 0091-6749 1097-6825 1097-6825 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 17q21 6p21 admixture mapping Adolescent African Americans Allergy and Immunology Asthma Asthma - diagnosis Asthma - ethnology Asthma - genetics Child Chromosome Mapping Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 6 Chronic illnesses Disease Estimates Female Genealogy Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genomes Hispanic or Latino Humans Ikaros Transcription Factor - genetics Latinos local ancestry Male Polymorphism, Single Nucleotide Proteins - genetics Statistical methods Studies United States Young Adult |
| title | Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: The Genes-environments & Admixture in Latino Americans study |
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