Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis

Background Cigarette smoke (CS) plays a role in the exacerbation of chronic rhinosinusitis (CRS); however, the mechanism for this is unknown. We hypothesize that CS impairs human sinonasal epithelial cell (HSNEC) conversion of 25(OH)D3 (25VD3) to 1,25-dihydroxyvitamin D3 (1,25VD3) and, furthermore,...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2014-08, Vol.134 (2), p.342-349.e1
Hauptverfasser:	Mulligan, Jennifer K., PhD, Nagel, Whitney, BS, O'Connell, Brendan P., MD, Wentzel, Jennifer, BS, Atkinson, Carl, PhD, Schlosser, Rodney J., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism Adult Aged Allergy and Immunology Calcifediol - metabolism Calcitriol - deficiency Calcitriol - pharmacology Case-Control Studies Chronic Disease Cigarettes Complex Mixtures - isolation & purification Complex Mixtures - pharmacology Cytokines Disease epithelial cell Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - metabolism Female Gene Expression Regulation Humans Male Middle Aged Nasal Polyps - complications Nasal Polyps - metabolism Nasal Polyps - pathology Nicotiana - chemistry Nicotine Patients Primary Cell Culture Respiratory diseases Respiratory Mucosa - cytology Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Rhinitis - complications Rhinitis - metabolism Rhinitis - pathology secondhand smoke Sinuses sinusitis Sinusitis - complications Sinusitis - metabolism Sinusitis - pathology Smoke Smoking Surgery Tobacco smoke Vitamin D Vitamin D Deficiency - complications Vitamin D Deficiency - metabolism Vitamin D Deficiency - pathology
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