Protective effects of apigenin against furan-induced toxicity in mice

Furan, a food contaminant formed by heating, is possibly carcinogenic to humans. In this study, we discussed the effect of administration of apigenin on furan-induced toxicity by determining the ROS content, oxidative damage, cytokine levels, DNA damage, and the liver and kidney damage in a mouse mo...

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Veröffentlicht in:	Food & function 2014-08, Vol.5 (8), p.1804-1812
Hauptverfasser:	Wang, Enting, Chen, Fang, Hu, Xiaosong, Yuan, Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Aldehydes - metabolism Animals Antioxidants - pharmacology Apigenin - pharmacology Aspartate Aminotransferases - blood Blood Urea Nitrogen Creatinine - blood DNA Damage - drug effects Dose-Response Relationship, Drug Furans - toxicity Glutathione - metabolism Glutathione Transferase - metabolism Interleukin-10 - blood Interleukin-1beta - blood Interleukin-6 - blood Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Male Mice Mice, Inbred BALB C Oxidative Stress - drug effects Peroxidase - metabolism Reactive Oxygen Species - metabolism Superoxide Dismutase - metabolism Tumor Necrosis Factor-alpha - blood
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