Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity

In the brain, enormous numbers of neurons have functional individuality and distinct circuit specificities. Clustered Protocadherins (Pcdhs), diversified cell-surface proteins, are stochastically expressed by alternative promoter choice and affect dendritic arborization in individual neurons. Here w...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2014-04, Vol.82 (1), p.94-108
Hauptverfasser:	Toyoda, Shunsuke, Kawaguchi, Masahumi, Kobayashi, Toshihiro, Tarusawa, Etsuko, Toyama, Tomoko, Okano, Masaki, Oda, Masaaki, Nakauchi, Hiromitsu, Yoshimura, Yumiko, Sanbo, Makoto, Hirabayashi, Masumi, Hirayama, Teruyoshi, Hirabayashi, Takahiro, Yagi, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Newborn Brain - cytology Brain - embryology Brain - growth & development Brain - metabolism Cadherins - genetics Cadherins - metabolism Cells, Cultured Chromatin Immunoprecipitation DNA (Cytosine-5-)-Methyltransferases - deficiency DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methylation DNA Methyltransferase 3B Embryo, Mammalian Epigenesis, Genetic - physiology Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - physiology Humans Mice Mice, Knockout Multigene Family - genetics Neurons - physiology Pluripotent Stem Cells - physiology Promoter Regions, Genetic - physiology Stochastic Processes
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