Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase

Complement receptor 3 (CR3) activation in microglia is involved in neuroinflammation-related brain disorders and pruning of neuronal synapses. Hypoxia, often observed together with neuroinflammation in brain trauma, stroke, and neurodegenerative diseases, is thought to exacerbate inflammatory respon...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2014-04, Vol.82 (1), p.195-207
Hauptverfasser:	Zhang, Jingfei, Malik, Aqsa, Choi, Hyun B, Ko, Rebecca W Y, Dissing-Olesen, Lasse, MacVicar, Brian A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - pharmacology Animals Animals, Newborn Brain research CD11b Antigen - metabolism Enzyme Inhibitors - pharmacology Excitatory Amino Acid Antagonists - pharmacology Hippocampus - physiology Hypoxia Hypoxia - physiopathology In Vitro Techniques L-Lactate Dehydrogenase - metabolism Ligands Lipid Peroxidation - genetics Long-Term Synaptic Depression - drug effects Long-Term Synaptic Depression - physiology Macrophage-1 Antigen - genetics Macrophage-1 Antigen - metabolism Medical research Mice Mice, Knockout Microglia - metabolism NADPH Oxidases - metabolism Oxygen - pharmacology Peptides Rats Rats, Sprague-Dawley Rodents Studies
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