Bioactivity of porous biphasic calcium phosphate enhanced by recombinant human bone morphogenetic protein 2/silk fibroin microsphere

To prepare a bioactive bone substitute, which integrates biphasic calcium phosphate (BCP) and rhBMP-2/silk fibroin (SF) microsphere, and to evaluate its characteristics. Hydroxyapatite and β-tricalcium phosphate were integrated with a ratio of 60–40 %. RhBMP-2/SF (0.5 μg/1 mg) microsphere was prepar...

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Veröffentlicht in:	Journal of materials science. Materials in medicine 2014-07, Vol.25 (7), p.1709-1719
Hauptverfasser:	Chen, Liang, Gu, Yong, Feng, Yu, Zhu, Xue-Song, Wang, Chun-Zeng, Liu, Hai-Long, Niu, Hai-Yun, Zhang, Chi, Yang, Hui-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials - chemistry Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Bombyx Bone and Bones - metabolism Bone Morphogenetic Protein 2 - chemistry Bones Calcium phosphates Calcium Phosphates - chemistry Cell Adhesion Cell Differentiation Cell Proliferation Cells, Cultured Ceramics Chemistry and Materials Science Composites Durapatite - chemistry Female Fibroins - chemistry Glass Humans Kinetics Materials Science Medical sciences Mesenchymal Stromal Cells - cytology Microscopy, Electron, Scanning Microspheres Natural Materials Placenta - metabolism Polymer Sciences Porosity Pregnancy Proteins Recombinant Proteins - chemistry Regenerative Medicine/Tissue Engineering Sodium Chloride - chemistry Stress, Mechanical Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Thin Films Time Factors Tissue engineering Transforming Growth Factor beta - chemistry
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