Fatty Acid Binding Protein 7 Regulates Phagocytosis and Cytokine Production in Kupffer Cells during Liver Injury

Kupffer cells (KCs) are involved in the progression of liver diseases such as hepatitis and liver cancer. Several members of the fatty acid binding proteins (FABPs) are expressed by tissue macrophages, and FABP7 is localized only in KCs. To clarify the role of FABP7 in the regulation of KC function,...

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Veröffentlicht in:	The American journal of pathology 2014-09, Vol.184 (9), p.2505-2515
Hauptverfasser:	Miyazaki, Hirofumi, Sawada, Tomoo, Kiyohira, Miwa, Yu, Zhiqian, Nakamura, Keiji, Yasumoto, Yuki, Kagawa, Yoshiteru, Ebrahimi, Majid, Islam, Ariful, Sharifi, Kazem, Kawamura, Saki, Kodama, Takanori, Yamamoto, Yui, Adachi, Yasuhiro, Tokuda, Nobuko, Terai, Shuji, Sakaida, Isao, Ishikawa, Toshizo, Owada, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Carbon Tetrachloride - toxicity Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Cytokines - biosynthesis Enzyme-Linked Immunosorbent Assay Fatty Acid-Binding Protein 7 Fatty Acid-Binding Proteins - metabolism Flow Cytometry Fluorescent Antibody Technique Immunohistochemistry In Situ Nick-End Labeling Kupffer Cells - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - metabolism Pathology Phagocytosis - physiology Reverse Transcriptase Polymerase Chain Reaction
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