TGF-β-dependent induction of CD4+ CD25+ Foxp3+ Tregs by liver sinusoidal endothelial cells

Background & Aims CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) have a profound ability to control immune responses. We have previously shown that the liver is a major source of peripherally induced Tregs. Here, we investigate the liver cell types and molecular mechanisms responsible for hepatic...

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Veröffentlicht in:	Journal of hepatology 2014-09, Vol.61 (3), p.594-599
Hauptverfasser:	Carambia, Antonella, Freund, Barbara, Schwinge, Dorothee, Heine, Markus, Laschtowitz, Alena, Huber, Samuel, Wraith, David C, Korn, Thomas, Schramm, Christoph, Lohse, Ansgar W, Heeren, Joerg, Herkel, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen presentation Autoimmunity Cell Communication - drug effects Cell Differentiation - drug effects Cells, Cultured Dendritic Cells - drug effects Dendritic Cells - pathology Endothelium - drug effects Endothelium - pathology Forkhead Transcription Factors - metabolism Gastroenterology and Hepatology Hepatic tolerance In Vitro Techniques Interleukin-2 Receptor alpha Subunit - metabolism Kupffer Cells - drug effects Kupffer Cells - pathology Liver - drug effects Liver - pathology Liver sinusoidal endothelial cells Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Mutant Strains Models, Animal Regulatory T cells T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology TGF-β Transforming Growth Factor beta - pharmacology
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