Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity
In this study we investigated the relationship between synovial vascularity (SV) and structural alteration of finger joints in patients with RA and long-term sustained clinical low disease activity (CLDA). RA patients with CLDA of >2 years (minimum 1 year of CLDA for study entry plus 1 year of ob...
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| Veröffentlicht in: | Rheumatology (Oxford, England) England), 2014-09, Vol.53 (9), p.1608-1612 |
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| creator | Fukae, Jun Isobe, Masato Kitano, Akemi Henmi, Mihoko Sakamoto, Fumihiko Narita, Akihiro Ito, Takeya Mitsuzaki, Akio Shimizu, Masato Tanimura, Kazuhide Matsuhashi, Megumi Kamishima, Tamotsu Atsumi, Tatsuya Koike, Takao |
| description | In this study we investigated the relationship between synovial vascularity (SV) and structural alteration of finger joints in patients with RA and long-term sustained clinical low disease activity (CLDA).
RA patients with CLDA of >2 years (minimum 1 year of CLDA for study entry plus 1 year of observation) were analysed. Quantitative SV values were sequentially measured in each finger joint using power Doppler ultrasonography (0, 8, 20 and 52 weeks). Radiological progression of local finger joints was evaluated according to the Genant-modified Sharp score (0-52 weeks).
Of the 25 patients enrolled, 15 patients were finally analysed after excluding 10 patients who failed to maintain CLDA during the observational period. Changes in radiological progression of MCP and PIP joints with positive SV were significantly greater than those in joints with negative SV. Joint space narrowing (JSN) was strongly related to structural alteration of finger joints. In joints with positive SV, changes in structural alteration did not relate to total SV values, which reflect total exposure to inflammation in an observational period.
Even in patients with a long period of CLDA, finger joints with positive SV showed structural alteration, especially in the progression of JSN.
University Hospital Medical Information Network Clinical Trials Registry, http://www.umin.ac.jp/ctr/, UMIN000007305. |
| doi_str_mv | 10.1093/rheumatology/keu154 |
| format | Article |
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RA patients with CLDA of >2 years (minimum 1 year of CLDA for study entry plus 1 year of observation) were analysed. Quantitative SV values were sequentially measured in each finger joint using power Doppler ultrasonography (0, 8, 20 and 52 weeks). Radiological progression of local finger joints was evaluated according to the Genant-modified Sharp score (0-52 weeks).
Of the 25 patients enrolled, 15 patients were finally analysed after excluding 10 patients who failed to maintain CLDA during the observational period. Changes in radiological progression of MCP and PIP joints with positive SV were significantly greater than those in joints with negative SV. Joint space narrowing (JSN) was strongly related to structural alteration of finger joints. In joints with positive SV, changes in structural alteration did not relate to total SV values, which reflect total exposure to inflammation in an observational period.
Even in patients with a long period of CLDA, finger joints with positive SV showed structural alteration, especially in the progression of JSN.
University Hospital Medical Information Network Clinical Trials Registry, http://www.umin.ac.jp/ctr/, UMIN000007305.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/keu154</identifier><identifier>PMID: 24706991</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Antirheumatic Agents - therapeutic use ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - drug therapy ; Disease Progression ; Female ; Finger Joint - blood supply ; Finger Joint - diagnostic imaging ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neovascularization, Pathologic - diagnostic imaging ; Neovascularization, Pathologic - etiology ; Severity of Illness Index ; Synovial Membrane - blood supply ; Synovial Membrane - diagnostic imaging ; Synovitis - diagnostic imaging ; Synovitis - etiology ; Ultrasonography, Doppler</subject><ispartof>Rheumatology (Oxford, England), 2014-09, Vol.53 (9), p.1608-1612</ispartof><rights>The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-fb947c09ec4167f9523902019d18f5201594a000b3a0c9afce142c4f0066e8083</citedby><cites>FETCH-LOGICAL-c464t-fb947c09ec4167f9523902019d18f5201594a000b3a0c9afce142c4f0066e8083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24706991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukae, Jun</creatorcontrib><creatorcontrib>Isobe, Masato</creatorcontrib><creatorcontrib>Kitano, Akemi</creatorcontrib><creatorcontrib>Henmi, Mihoko</creatorcontrib><creatorcontrib>Sakamoto, Fumihiko</creatorcontrib><creatorcontrib>Narita, Akihiro</creatorcontrib><creatorcontrib>Ito, Takeya</creatorcontrib><creatorcontrib>Mitsuzaki, Akio</creatorcontrib><creatorcontrib>Shimizu, Masato</creatorcontrib><creatorcontrib>Tanimura, Kazuhide</creatorcontrib><creatorcontrib>Matsuhashi, Megumi</creatorcontrib><creatorcontrib>Kamishima, Tamotsu</creatorcontrib><creatorcontrib>Atsumi, Tatsuya</creatorcontrib><creatorcontrib>Koike, Takao</creatorcontrib><title>Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>In this study we investigated the relationship between synovial vascularity (SV) and structural alteration of finger joints in patients with RA and long-term sustained clinical low disease activity (CLDA).
RA patients with CLDA of >2 years (minimum 1 year of CLDA for study entry plus 1 year of observation) were analysed. Quantitative SV values were sequentially measured in each finger joint using power Doppler ultrasonography (0, 8, 20 and 52 weeks). Radiological progression of local finger joints was evaluated according to the Genant-modified Sharp score (0-52 weeks).
Of the 25 patients enrolled, 15 patients were finally analysed after excluding 10 patients who failed to maintain CLDA during the observational period. Changes in radiological progression of MCP and PIP joints with positive SV were significantly greater than those in joints with negative SV. Joint space narrowing (JSN) was strongly related to structural alteration of finger joints. In joints with positive SV, changes in structural alteration did not relate to total SV values, which reflect total exposure to inflammation in an observational period.
Even in patients with a long period of CLDA, finger joints with positive SV showed structural alteration, especially in the progression of JSN.
University Hospital Medical Information Network Clinical Trials Registry, http://www.umin.ac.jp/ctr/, UMIN000007305.</description><subject>Adult</subject><subject>Aged</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Finger Joint - blood supply</subject><subject>Finger Joint - diagnostic imaging</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neovascularization, Pathologic - diagnostic imaging</subject><subject>Neovascularization, Pathologic - etiology</subject><subject>Severity of Illness Index</subject><subject>Synovial Membrane - blood supply</subject><subject>Synovial Membrane - diagnostic imaging</subject><subject>Synovitis - diagnostic imaging</subject><subject>Synovitis - etiology</subject><subject>Ultrasonography, Doppler</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUctOwzAQtBCIlsIXICEfuQTs2EnjI6p4SZU4AOfIddaNixMX26HKR_DPBPoQpx2tdmZ2dxC6pOSGEsFufQ1dI6OzbtnffkBHM36ExpTnaUIYS48POOUjdBbCihCSUVacolHKpyQXgo7R92v0nYqdlxZXEMEb52U0rsVOY23aJXi8cqaNAW9MrHFno5fBtW7p5bo2Coe-dV8mmoBNi_crmQpLH2v_118PenAQUNa0Rg1u1m1wZQLIAFiqaAaR_hydaGkDXOzqBL0_3L_NnpL5y-Pz7G6eKJ7zmOiF4FNFBChO86kWWcoESQkVFS10NoBMcDlcu2CSKCG1AspTxTUheQ4FKdgEXW911959dhBi2ZigwFrZgutCSbOMC054xodRth1V3oXgQZdrbxrp-5KS8jeH8n8O5TaHgXW1M-gWDVQHzv7x7AcHP400</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Fukae, Jun</creator><creator>Isobe, Masato</creator><creator>Kitano, Akemi</creator><creator>Henmi, Mihoko</creator><creator>Sakamoto, Fumihiko</creator><creator>Narita, Akihiro</creator><creator>Ito, Takeya</creator><creator>Mitsuzaki, Akio</creator><creator>Shimizu, Masato</creator><creator>Tanimura, Kazuhide</creator><creator>Matsuhashi, Megumi</creator><creator>Kamishima, Tamotsu</creator><creator>Atsumi, Tatsuya</creator><creator>Koike, Takao</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity</title><author>Fukae, Jun ; Isobe, Masato ; Kitano, Akemi ; Henmi, Mihoko ; Sakamoto, Fumihiko ; Narita, Akihiro ; Ito, Takeya ; Mitsuzaki, Akio ; Shimizu, Masato ; Tanimura, Kazuhide ; Matsuhashi, Megumi ; Kamishima, Tamotsu ; Atsumi, Tatsuya ; Koike, Takao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-fb947c09ec4167f9523902019d18f5201594a000b3a0c9afce142c4f0066e8083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antirheumatic Agents - therapeutic use</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Finger Joint - blood supply</topic><topic>Finger Joint - diagnostic imaging</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neovascularization, Pathologic - diagnostic imaging</topic><topic>Neovascularization, Pathologic - etiology</topic><topic>Severity of Illness Index</topic><topic>Synovial Membrane - blood supply</topic><topic>Synovial Membrane - diagnostic imaging</topic><topic>Synovitis - diagnostic imaging</topic><topic>Synovitis - etiology</topic><topic>Ultrasonography, Doppler</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukae, Jun</creatorcontrib><creatorcontrib>Isobe, Masato</creatorcontrib><creatorcontrib>Kitano, Akemi</creatorcontrib><creatorcontrib>Henmi, Mihoko</creatorcontrib><creatorcontrib>Sakamoto, Fumihiko</creatorcontrib><creatorcontrib>Narita, Akihiro</creatorcontrib><creatorcontrib>Ito, Takeya</creatorcontrib><creatorcontrib>Mitsuzaki, Akio</creatorcontrib><creatorcontrib>Shimizu, Masato</creatorcontrib><creatorcontrib>Tanimura, Kazuhide</creatorcontrib><creatorcontrib>Matsuhashi, Megumi</creatorcontrib><creatorcontrib>Kamishima, Tamotsu</creatorcontrib><creatorcontrib>Atsumi, Tatsuya</creatorcontrib><creatorcontrib>Koike, Takao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukae, Jun</au><au>Isobe, Masato</au><au>Kitano, Akemi</au><au>Henmi, Mihoko</au><au>Sakamoto, Fumihiko</au><au>Narita, Akihiro</au><au>Ito, Takeya</au><au>Mitsuzaki, Akio</au><au>Shimizu, Masato</au><au>Tanimura, Kazuhide</au><au>Matsuhashi, Megumi</au><au>Kamishima, Tamotsu</au><au>Atsumi, Tatsuya</au><au>Koike, Takao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>53</volume><issue>9</issue><spage>1608</spage><epage>1612</epage><pages>1608-1612</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><abstract>In this study we investigated the relationship between synovial vascularity (SV) and structural alteration of finger joints in patients with RA and long-term sustained clinical low disease activity (CLDA).
RA patients with CLDA of >2 years (minimum 1 year of CLDA for study entry plus 1 year of observation) were analysed. Quantitative SV values were sequentially measured in each finger joint using power Doppler ultrasonography (0, 8, 20 and 52 weeks). Radiological progression of local finger joints was evaluated according to the Genant-modified Sharp score (0-52 weeks).
Of the 25 patients enrolled, 15 patients were finally analysed after excluding 10 patients who failed to maintain CLDA during the observational period. Changes in radiological progression of MCP and PIP joints with positive SV were significantly greater than those in joints with negative SV. Joint space narrowing (JSN) was strongly related to structural alteration of finger joints. In joints with positive SV, changes in structural alteration did not relate to total SV values, which reflect total exposure to inflammation in an observational period.
Even in patients with a long period of CLDA, finger joints with positive SV showed structural alteration, especially in the progression of JSN.
University Hospital Medical Information Network Clinical Trials Registry, http://www.umin.ac.jp/ctr/, UMIN000007305.</abstract><cop>England</cop><pmid>24706991</pmid><doi>10.1093/rheumatology/keu154</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1462-0324 |
| ispartof | Rheumatology (Oxford, England), 2014-09, Vol.53 (9), p.1608-1612 |
| issn | 1462-0324 1462-0332 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - drug therapy Disease Progression Female Finger Joint - blood supply Finger Joint - diagnostic imaging Follow-Up Studies Humans Male Middle Aged Neovascularization, Pathologic - diagnostic imaging Neovascularization, Pathologic - etiology Severity of Illness Index Synovial Membrane - blood supply Synovial Membrane - diagnostic imaging Synovitis - diagnostic imaging Synovitis - etiology Ultrasonography, Doppler |
| title | Structural deterioration of finger joints with ultrasonographic synovitis in rheumatoid arthritis patients with clinical low disease activity |
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