Treatment patterns, risk factor control and functional capacity in patients with cardiovascular and chronic kidney disease in the cardiac rehabilitation setting
Background Chronic kidney disease (CKD) is a frequent comorbidity among elderly patients and those with cardiovascular disease. CKD carries prognostic relevance. We aimed to describe patient characteristics, risk factor management and control status of patients in cardiac rehabilitation (CR), differ...
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| Veröffentlicht in: | European journal of preventive cardiology 2014-09, Vol.21 (9), p.1125-1133 |
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| creator | Völler, Heinz Gitt, Anselm Jannowitz, Christina Karoff, Marthin Karmann, Barbara Pittrow, David Reibis, Rona Hildemann, Steven |
| description | Background
Chronic kidney disease (CKD) is a frequent comorbidity among elderly patients and those with cardiovascular disease. CKD carries prognostic relevance. We aimed to describe patient characteristics, risk factor management and control status of patients in cardiac rehabilitation (CR), differentiated by presence or absence of CKD.
Design and methods
Data from 92,071 inpatients with adequate information to calculate glomerular filtration rate (GFR) based on the Cockcroft–Gault formula were analyzed at the beginning and the end of a 3-week CR stay. CKD was defined as estimated GFR |
| doi_str_mv | 10.1177/2047487313482285 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1554939198</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_2047487313482285</sage_id><sourcerecordid>1554939198</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-c76fe48b897b3643083b16b7ff140eb8347000165a6316e344b61a7e7ff80c843</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhi0EolXpnRPyBYkDoXbsxM4RVRSQKvVSztHEmXTdZu3F44D2bfqoOOxSJCR8sTX-vhlpfsZeS_FBSmMuaqGNtkZJpW1d2-YZO11LlbZWPn96G3XCzonuRTmtKJx9yU5q1Qjb1eaUPd4mhLzFkPkOcsYU6D1Pnh74BC7HxF0MOcWZQxj5tASXfQwwcwc7cD7vuQ-r6EsD4j993pSfNPr4A8gtM6TfntukGLzjD34MuOejJwTCVc0bPAjgeMINDH72GdYZnDBnH-5esRcTzITnx_uMfbv6dHv5pbq--fz18uN15bTocuVMO6G2g-3MoFqthFWDbAczTVILHKzSpixAtg20SraotB5aCQYLYIWzWp2xd4e-uxS_L0i533pyOM8QMC7Uy6bRnepkZwsqDqhLkSjh1O-S30La91L0azT9v9EU5c2x-zJscXwS_gRRgLdHoCwO5ilBcJ7-ctY0woiVqw4cwR3293FJJQ36_-BfWW-lkQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1554939198</pqid></control><display><type>article</type><title>Treatment patterns, risk factor control and functional capacity in patients with cardiovascular and chronic kidney disease in the cardiac rehabilitation setting</title><source>Access via SAGE</source><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Völler, Heinz ; Gitt, Anselm ; Jannowitz, Christina ; Karoff, Marthin ; Karmann, Barbara ; Pittrow, David ; Reibis, Rona ; Hildemann, Steven</creator><creatorcontrib>Völler, Heinz ; Gitt, Anselm ; Jannowitz, Christina ; Karoff, Marthin ; Karmann, Barbara ; Pittrow, David ; Reibis, Rona ; Hildemann, Steven</creatorcontrib><description>Background
Chronic kidney disease (CKD) is a frequent comorbidity among elderly patients and those with cardiovascular disease. CKD carries prognostic relevance. We aimed to describe patient characteristics, risk factor management and control status of patients in cardiac rehabilitation (CR), differentiated by presence or absence of CKD.
Design and methods
Data from 92,071 inpatients with adequate information to calculate glomerular filtration rate (GFR) based on the Cockcroft–Gault formula were analyzed at the beginning and the end of a 3-week CR stay. CKD was defined as estimated GFR <60 ml/min/1.73 m2.
Results
Compared with non-CKD patients, CKD patients were significantly older (72.0 versus 58.0 years) and more often had diabetes mellitus, arterial hypertension, and atherothrombotic manifestations (previous stroke, peripheral arterial disease), but fewer were current or previous smokers had a CHD family history. Exercise capacity was much lower in CKD (59 vs. 92 Watts). Fewer patients with CKD were treated with percutaneous coronary intervention (PCI), but more had coronary artery bypass graft (CABG) surgery.
Patients with CKD compared with non-CKD less frequently received statins, acetylsalicylic acid (ASA), clopidogrel, beta blockers, and angiotensin converting enzyme (ACE) inhibitors, and more frequently received angiotensin receptor blockers, insulin and oral anticoagulants. In CKD, mean low density lipoprotein cholesterol (LDL-C), total cholesterol, and high density lipoprotein cholesterol (HDL-C) were slightly higher at baseline, while triglycerides were substantially lower. This lipid pattern did not change at the discharge visit, but overall control rates for all described parameters (with the exception of HDL-C) were improved substantially. At discharge, systolic blood pressure (BP) was higher in CKD (124 versus 121 mmHg) and diastolic BP was lower (72 versus 74 mmHg). At discharge, 68.7% of CKD versus 71.9% of non-CKD patients had LDL-C <100 mg/dl. Physical fitness on exercise testing improved substantially in both groups.
When the Modification of Diet in Renal Disease (MDRD) formula was used for CKD classification, there was no clinically relevant change in these results.
Conclusion
Within a short period of 3–4 weeks, CR led to substantial improvements in key risk factors such as lipid profile, blood pressure, and physical fitness for all patients, even if CKD was present.</description><identifier>ISSN: 2047-4873</identifier><identifier>EISSN: 2047-4881</identifier><identifier>DOI: 10.1177/2047487313482285</identifier><identifier>PMID: 23508927</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Biological and medical sciences ; Blood Pressure ; Cardiac Rehabilitation ; Cardiology. Vascular system ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - physiopathology ; Comorbidity ; Exercise Therapy - methods ; Exercise Tolerance - physiology ; Female ; Follow-Up Studies ; Germany - epidemiology ; Glomerular Filtration Rate ; Heart ; Humans ; Kidneys ; Male ; Medical sciences ; Middle Aged ; Motor Activity - physiology ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Patient Compliance ; Prognosis ; Prospective Studies ; Renal failure ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - physiopathology ; Renal Insufficiency, Chronic - rehabilitation ; Risk Assessment - methods ; Risk Factors ; Urinary system involvement in other diseases. Miscellaneous</subject><ispartof>European journal of preventive cardiology, 2014-09, Vol.21 (9), p.1125-1133</ispartof><rights>Authors 2013</rights><rights>2015 INIST-CNRS</rights><rights>Authors 2013.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-c76fe48b897b3643083b16b7ff140eb8347000165a6316e344b61a7e7ff80c843</citedby><cites>FETCH-LOGICAL-c409t-c76fe48b897b3643083b16b7ff140eb8347000165a6316e344b61a7e7ff80c843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/2047487313482285$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/2047487313482285$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28750707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23508927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Völler, Heinz</creatorcontrib><creatorcontrib>Gitt, Anselm</creatorcontrib><creatorcontrib>Jannowitz, Christina</creatorcontrib><creatorcontrib>Karoff, Marthin</creatorcontrib><creatorcontrib>Karmann, Barbara</creatorcontrib><creatorcontrib>Pittrow, David</creatorcontrib><creatorcontrib>Reibis, Rona</creatorcontrib><creatorcontrib>Hildemann, Steven</creatorcontrib><title>Treatment patterns, risk factor control and functional capacity in patients with cardiovascular and chronic kidney disease in the cardiac rehabilitation setting</title><title>European journal of preventive cardiology</title><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><description>Background
Chronic kidney disease (CKD) is a frequent comorbidity among elderly patients and those with cardiovascular disease. CKD carries prognostic relevance. We aimed to describe patient characteristics, risk factor management and control status of patients in cardiac rehabilitation (CR), differentiated by presence or absence of CKD.
Design and methods
Data from 92,071 inpatients with adequate information to calculate glomerular filtration rate (GFR) based on the Cockcroft–Gault formula were analyzed at the beginning and the end of a 3-week CR stay. CKD was defined as estimated GFR <60 ml/min/1.73 m2.
Results
Compared with non-CKD patients, CKD patients were significantly older (72.0 versus 58.0 years) and more often had diabetes mellitus, arterial hypertension, and atherothrombotic manifestations (previous stroke, peripheral arterial disease), but fewer were current or previous smokers had a CHD family history. Exercise capacity was much lower in CKD (59 vs. 92 Watts). Fewer patients with CKD were treated with percutaneous coronary intervention (PCI), but more had coronary artery bypass graft (CABG) surgery.
Patients with CKD compared with non-CKD less frequently received statins, acetylsalicylic acid (ASA), clopidogrel, beta blockers, and angiotensin converting enzyme (ACE) inhibitors, and more frequently received angiotensin receptor blockers, insulin and oral anticoagulants. In CKD, mean low density lipoprotein cholesterol (LDL-C), total cholesterol, and high density lipoprotein cholesterol (HDL-C) were slightly higher at baseline, while triglycerides were substantially lower. This lipid pattern did not change at the discharge visit, but overall control rates for all described parameters (with the exception of HDL-C) were improved substantially. At discharge, systolic blood pressure (BP) was higher in CKD (124 versus 121 mmHg) and diastolic BP was lower (72 versus 74 mmHg). At discharge, 68.7% of CKD versus 71.9% of non-CKD patients had LDL-C <100 mg/dl. Physical fitness on exercise testing improved substantially in both groups.
When the Modification of Diet in Renal Disease (MDRD) formula was used for CKD classification, there was no clinically relevant change in these results.
Conclusion
Within a short period of 3–4 weeks, CR led to substantial improvements in key risk factors such as lipid profile, blood pressure, and physical fitness for all patients, even if CKD was present.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Cardiac Rehabilitation</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Comorbidity</subject><subject>Exercise Therapy - methods</subject><subject>Exercise Tolerance - physiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Germany - epidemiology</subject><subject>Glomerular Filtration Rate</subject><subject>Heart</subject><subject>Humans</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor Activity - physiology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Patient Compliance</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Renal failure</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Renal Insufficiency, Chronic - rehabilitation</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><issn>2047-4873</issn><issn>2047-4881</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhi0EolXpnRPyBYkDoXbsxM4RVRSQKvVSztHEmXTdZu3F44D2bfqoOOxSJCR8sTX-vhlpfsZeS_FBSmMuaqGNtkZJpW1d2-YZO11LlbZWPn96G3XCzonuRTmtKJx9yU5q1Qjb1eaUPd4mhLzFkPkOcsYU6D1Pnh74BC7HxF0MOcWZQxj5tASXfQwwcwc7cD7vuQ-r6EsD4j993pSfNPr4A8gtM6TfntukGLzjD34MuOejJwTCVc0bPAjgeMINDH72GdYZnDBnH-5esRcTzITnx_uMfbv6dHv5pbq--fz18uN15bTocuVMO6G2g-3MoFqthFWDbAczTVILHKzSpixAtg20SraotB5aCQYLYIWzWp2xd4e-uxS_L0i533pyOM8QMC7Uy6bRnepkZwsqDqhLkSjh1O-S30La91L0azT9v9EU5c2x-zJscXwS_gRRgLdHoCwO5ilBcJ7-ctY0woiVqw4cwR3293FJJQ36_-BfWW-lkQ</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Völler, Heinz</creator><creator>Gitt, Anselm</creator><creator>Jannowitz, Christina</creator><creator>Karoff, Marthin</creator><creator>Karmann, Barbara</creator><creator>Pittrow, David</creator><creator>Reibis, Rona</creator><creator>Hildemann, Steven</creator><general>SAGE Publications</general><general>Sage Publications</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Treatment patterns, risk factor control and functional capacity in patients with cardiovascular and chronic kidney disease in the cardiac rehabilitation setting</title><author>Völler, Heinz ; Gitt, Anselm ; Jannowitz, Christina ; Karoff, Marthin ; Karmann, Barbara ; Pittrow, David ; Reibis, Rona ; Hildemann, Steven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-c76fe48b897b3643083b16b7ff140eb8347000165a6316e344b61a7e7ff80c843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Cardiac Rehabilitation</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Comorbidity</topic><topic>Exercise Therapy - methods</topic><topic>Exercise Tolerance - physiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Germany - epidemiology</topic><topic>Glomerular Filtration Rate</topic><topic>Heart</topic><topic>Humans</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor Activity - physiology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Patient Compliance</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Renal failure</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Renal Insufficiency, Chronic - physiopathology</topic><topic>Renal Insufficiency, Chronic - rehabilitation</topic><topic>Risk Assessment - methods</topic><topic>Risk Factors</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Völler, Heinz</creatorcontrib><creatorcontrib>Gitt, Anselm</creatorcontrib><creatorcontrib>Jannowitz, Christina</creatorcontrib><creatorcontrib>Karoff, Marthin</creatorcontrib><creatorcontrib>Karmann, Barbara</creatorcontrib><creatorcontrib>Pittrow, David</creatorcontrib><creatorcontrib>Reibis, Rona</creatorcontrib><creatorcontrib>Hildemann, Steven</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of preventive cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Völler, Heinz</au><au>Gitt, Anselm</au><au>Jannowitz, Christina</au><au>Karoff, Marthin</au><au>Karmann, Barbara</au><au>Pittrow, David</au><au>Reibis, Rona</au><au>Hildemann, Steven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment patterns, risk factor control and functional capacity in patients with cardiovascular and chronic kidney disease in the cardiac rehabilitation setting</atitle><jtitle>European journal of preventive cardiology</jtitle><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>21</volume><issue>9</issue><spage>1125</spage><epage>1133</epage><pages>1125-1133</pages><issn>2047-4873</issn><eissn>2047-4881</eissn><abstract>Background
Chronic kidney disease (CKD) is a frequent comorbidity among elderly patients and those with cardiovascular disease. CKD carries prognostic relevance. We aimed to describe patient characteristics, risk factor management and control status of patients in cardiac rehabilitation (CR), differentiated by presence or absence of CKD.
Design and methods
Data from 92,071 inpatients with adequate information to calculate glomerular filtration rate (GFR) based on the Cockcroft–Gault formula were analyzed at the beginning and the end of a 3-week CR stay. CKD was defined as estimated GFR <60 ml/min/1.73 m2.
Results
Compared with non-CKD patients, CKD patients were significantly older (72.0 versus 58.0 years) and more often had diabetes mellitus, arterial hypertension, and atherothrombotic manifestations (previous stroke, peripheral arterial disease), but fewer were current or previous smokers had a CHD family history. Exercise capacity was much lower in CKD (59 vs. 92 Watts). Fewer patients with CKD were treated with percutaneous coronary intervention (PCI), but more had coronary artery bypass graft (CABG) surgery.
Patients with CKD compared with non-CKD less frequently received statins, acetylsalicylic acid (ASA), clopidogrel, beta blockers, and angiotensin converting enzyme (ACE) inhibitors, and more frequently received angiotensin receptor blockers, insulin and oral anticoagulants. In CKD, mean low density lipoprotein cholesterol (LDL-C), total cholesterol, and high density lipoprotein cholesterol (HDL-C) were slightly higher at baseline, while triglycerides were substantially lower. This lipid pattern did not change at the discharge visit, but overall control rates for all described parameters (with the exception of HDL-C) were improved substantially. At discharge, systolic blood pressure (BP) was higher in CKD (124 versus 121 mmHg) and diastolic BP was lower (72 versus 74 mmHg). At discharge, 68.7% of CKD versus 71.9% of non-CKD patients had LDL-C <100 mg/dl. Physical fitness on exercise testing improved substantially in both groups.
When the Modification of Diet in Renal Disease (MDRD) formula was used for CKD classification, there was no clinically relevant change in these results.
Conclusion
Within a short period of 3–4 weeks, CR led to substantial improvements in key risk factors such as lipid profile, blood pressure, and physical fitness for all patients, even if CKD was present.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>23508927</pmid><doi>10.1177/2047487313482285</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2047-4873 |
| ispartof | European journal of preventive cardiology, 2014-09, Vol.21 (9), p.1125-1133 |
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| subjects | Aged Biological and medical sciences Blood Pressure Cardiac Rehabilitation Cardiology. Vascular system Cardiovascular Diseases - epidemiology Cardiovascular Diseases - physiopathology Comorbidity Exercise Therapy - methods Exercise Tolerance - physiology Female Follow-Up Studies Germany - epidemiology Glomerular Filtration Rate Heart Humans Kidneys Male Medical sciences Middle Aged Motor Activity - physiology Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Patient Compliance Prognosis Prospective Studies Renal failure Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - physiopathology Renal Insufficiency, Chronic - rehabilitation Risk Assessment - methods Risk Factors Urinary system involvement in other diseases. Miscellaneous |
| title | Treatment patterns, risk factor control and functional capacity in patients with cardiovascular and chronic kidney disease in the cardiac rehabilitation setting |
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