An investigation of the genetic toxicology of irradiated foodstuffs using short-term test systems. iii- in vivo tests in small rodents and in drosophila melanogaster
Six in vivo genetic toxicity tests were carried out on irradiated or unirradiated cooked chicken, dried dates and cooked fish. The tests were as follows: sex-linked recessive lethal mutations in Drosophila melanogaster (dried dales only), chromosome aberrations in bone marrow of Chinese hamsters, mi...
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| Veröffentlicht in: | Food and chemical toxicology 1982, Vol.20 (6), p.867-878 |
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| container_title | Food and chemical toxicology |
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| creator | renner, H.W. Graf, U. Würgler, F.E. altmann, H. asquith, J.C. elias, P.S. |
| description | Six
in vivo genetic toxicity tests were carried out on irradiated or unirradiated cooked chicken, dried dates and cooked fish. The tests were as follows: sex-linked recessive lethal mutations in
Drosophila melanogaster (dried dales only), chromosome aberrations in bone marrow of Chinese hamsters, micronucleus test in rats, mice and Chinese hamsters, sister-chromatid exchange in bone marrow of mice and Chinese hamsters and in spermalogonia of mice, and DNA metabolism in spleen cells of Chinese hamsters. None of the tests provided any evidence of genetic toxicity induced by irradiation. However, dried dates, whether irradiated or not, showed evidence of some genetic toxicity in their effect on DNA metabolism in spleen cells and SCE induction in bone marrow. Feeding irradiated fish affected DNA metabolism in the spleen cells of Chinese hamsters. This effect could be interpreted as an induction of an immunoactive compound, although it could also be explained by the persistence of an immunoaclive compound due to the removal by irradiation of spoilage organisms that would normally degrade it. |
| doi_str_mv | 10.1016/S0015-6264(82)80220-4 |
| format | Article |
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in vivo genetic toxicity tests were carried out on irradiated or unirradiated cooked chicken, dried dates and cooked fish. The tests were as follows: sex-linked recessive lethal mutations in
Drosophila melanogaster (dried dales only), chromosome aberrations in bone marrow of Chinese hamsters, micronucleus test in rats, mice and Chinese hamsters, sister-chromatid exchange in bone marrow of mice and Chinese hamsters and in spermalogonia of mice, and DNA metabolism in spleen cells of Chinese hamsters. None of the tests provided any evidence of genetic toxicity induced by irradiation. However, dried dates, whether irradiated or not, showed evidence of some genetic toxicity in their effect on DNA metabolism in spleen cells and SCE induction in bone marrow. Feeding irradiated fish affected DNA metabolism in the spleen cells of Chinese hamsters. This effect could be interpreted as an induction of an immunoactive compound, although it could also be explained by the persistence of an immunoaclive compound due to the removal by irradiation of spoilage organisms that would normally degrade it.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/S0015-6264(82)80220-4</identifier><identifier>PMID: 6819216</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Chickens ; Cricetinae ; Cricetulus ; Drosophila melanogaster ; Female ; Fishes ; food contamination ; Food Irradiation - adverse effects ; Fruit - radiation effects ; Male ; Meat - radiation effects ; Mice ; Mutagenicity Tests ; Mutation - radiation effects ; Rats ; Rats, Inbred Strains</subject><ispartof>Food and chemical toxicology, 1982, Vol.20 (6), p.867-878</ispartof><rights>1982 Pergamon Press Limited</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-9c097cdeab4d6cea1e643af0df211f69ec6e567d8dc31cdea0ce7fbb8adab7ac3</citedby><cites>FETCH-LOGICAL-c330t-9c097cdeab4d6cea1e643af0df211f69ec6e567d8dc31cdea0ce7fbb8adab7ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-6264(82)80220-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6819216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>renner, H.W.</creatorcontrib><creatorcontrib>Graf, U.</creatorcontrib><creatorcontrib>Würgler, F.E.</creatorcontrib><creatorcontrib>altmann, H.</creatorcontrib><creatorcontrib>asquith, J.C.</creatorcontrib><creatorcontrib>elias, P.S.</creatorcontrib><title>An investigation of the genetic toxicology of irradiated foodstuffs using short-term test systems. iii- in vivo tests in small rodents and in drosophila melanogaster</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Six
in vivo genetic toxicity tests were carried out on irradiated or unirradiated cooked chicken, dried dates and cooked fish. The tests were as follows: sex-linked recessive lethal mutations in
Drosophila melanogaster (dried dales only), chromosome aberrations in bone marrow of Chinese hamsters, micronucleus test in rats, mice and Chinese hamsters, sister-chromatid exchange in bone marrow of mice and Chinese hamsters and in spermalogonia of mice, and DNA metabolism in spleen cells of Chinese hamsters. None of the tests provided any evidence of genetic toxicity induced by irradiation. However, dried dates, whether irradiated or not, showed evidence of some genetic toxicity in their effect on DNA metabolism in spleen cells and SCE induction in bone marrow. Feeding irradiated fish affected DNA metabolism in the spleen cells of Chinese hamsters. This effect could be interpreted as an induction of an immunoactive compound, although it could also be explained by the persistence of an immunoaclive compound due to the removal by irradiation of spoilage organisms that would normally degrade it.</description><subject>Animals</subject><subject>Chickens</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>Drosophila melanogaster</subject><subject>Female</subject><subject>Fishes</subject><subject>food contamination</subject><subject>Food Irradiation - adverse effects</subject><subject>Fruit - radiation effects</subject><subject>Male</subject><subject>Meat - radiation effects</subject><subject>Mice</subject><subject>Mutagenicity Tests</subject><subject>Mutation - radiation effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcFu1DAQtRCobAufUOETgkOK7SROckJVBQWpEofSs-XY4-ygJF5sZ9X9IP4TZ3fFldNo5r158zSPkGvObjjj8tMjY7wupJDVh1Z8bJkQrKhekA1vm7KQZc1fkg0TTVvIjtevyWWMvxhjDW_kBbmQLe8Elxvy53amOO8hJhx0Qj9T72jaAh1ghoSGJv-Mxo9-OKwIhqAt6gSWOu9tTItzkS4R54HGrQ-pSBAmmrIejYeYYIo3FBGLfITuce-PUFy7OOlxpMFbmPNAz3Yd2uCj321x1HSCUc9-0FkkvCGvnB4jvD3XK_L09cvPu2_Fw4_773e3D4UpS5aKzrCuMRZ0X1lpQHOQVakds05w7mQHRkItG9taU_KVxww0ru9bbXXfaFNekfcn3V3wv5fsVE0YDYzZCfglKl7XVdXVbSbWJ6LJhmMAp3YBJx0OijO1xqOO8ag1HtUKdYxHVXnv-nxg6Sew_7bOeWT83Ql32is9BIzq6VEwXjIheVmVLDM-nxiQ_7BHCCoahNmAxQAmKevxPx7-An_uruI</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>renner, H.W.</creator><creator>Graf, U.</creator><creator>Würgler, F.E.</creator><creator>altmann, H.</creator><creator>asquith, J.C.</creator><creator>elias, P.S.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1982</creationdate><title>An investigation of the genetic toxicology of irradiated foodstuffs using short-term test systems. iii- in vivo tests in small rodents and in drosophila melanogaster</title><author>renner, H.W. ; Graf, U. ; Würgler, F.E. ; altmann, H. ; asquith, J.C. ; elias, P.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-9c097cdeab4d6cea1e643af0df211f69ec6e567d8dc31cdea0ce7fbb8adab7ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Chickens</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>Drosophila melanogaster</topic><topic>Female</topic><topic>Fishes</topic><topic>food contamination</topic><topic>Food Irradiation - adverse effects</topic><topic>Fruit - radiation effects</topic><topic>Male</topic><topic>Meat - radiation effects</topic><topic>Mice</topic><topic>Mutagenicity Tests</topic><topic>Mutation - radiation effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>renner, H.W.</creatorcontrib><creatorcontrib>Graf, U.</creatorcontrib><creatorcontrib>Würgler, F.E.</creatorcontrib><creatorcontrib>altmann, H.</creatorcontrib><creatorcontrib>asquith, J.C.</creatorcontrib><creatorcontrib>elias, P.S.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>renner, H.W.</au><au>Graf, U.</au><au>Würgler, F.E.</au><au>altmann, H.</au><au>asquith, J.C.</au><au>elias, P.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An investigation of the genetic toxicology of irradiated foodstuffs using short-term test systems. iii- in vivo tests in small rodents and in drosophila melanogaster</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>1982</date><risdate>1982</risdate><volume>20</volume><issue>6</issue><spage>867</spage><epage>878</epage><pages>867-878</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><abstract>Six
in vivo genetic toxicity tests were carried out on irradiated or unirradiated cooked chicken, dried dates and cooked fish. The tests were as follows: sex-linked recessive lethal mutations in
Drosophila melanogaster (dried dales only), chromosome aberrations in bone marrow of Chinese hamsters, micronucleus test in rats, mice and Chinese hamsters, sister-chromatid exchange in bone marrow of mice and Chinese hamsters and in spermalogonia of mice, and DNA metabolism in spleen cells of Chinese hamsters. None of the tests provided any evidence of genetic toxicity induced by irradiation. However, dried dates, whether irradiated or not, showed evidence of some genetic toxicity in their effect on DNA metabolism in spleen cells and SCE induction in bone marrow. Feeding irradiated fish affected DNA metabolism in the spleen cells of Chinese hamsters. This effect could be interpreted as an induction of an immunoactive compound, although it could also be explained by the persistence of an immunoaclive compound due to the removal by irradiation of spoilage organisms that would normally degrade it.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>6819216</pmid><doi>10.1016/S0015-6264(82)80220-4</doi><tpages>12</tpages></addata></record> |
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| ispartof | Food and chemical toxicology, 1982, Vol.20 (6), p.867-878 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Chickens Cricetinae Cricetulus Drosophila melanogaster Female Fishes food contamination Food Irradiation - adverse effects Fruit - radiation effects Male Meat - radiation effects Mice Mutagenicity Tests Mutation - radiation effects Rats Rats, Inbred Strains |
| title | An investigation of the genetic toxicology of irradiated foodstuffs using short-term test systems. iii- in vivo tests in small rodents and in drosophila melanogaster |
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