Breast cancer metastasis: demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12

The X‐linked transcription factor FOXP3 is expressed by epithelial cells of organs including the breast, where it is considered a tumour suppressor. The chemokine receptor CXCR4 also regulates the development of breast cancer by stimulating cell migration towards CXCL12‐expressing sites of metastati...

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Veröffentlicht in:	The Journal of pathology 2014-09, Vol.234 (1), p.74-85
Hauptverfasser:	Douglass, Stephen, Meeson, Annette P, Overbeck-Zubrzycka, Dorota, Brain, John G, Bennett, Miriam R, Lamb, Christopher A, Lennard, Thomas WJ, Browell, David, Ali, Simi, Kirby, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast - metabolism Breast - pathology breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Cycle Cell Line, Tumor Cell Proliferation chemokine Chemokine CXCL12 - genetics Chemokine CXCL12 - metabolism Chemotaxis CXCR4 Down-Regulation Epithelial Cells - metabolism Epithelial Cells - pathology Female Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FOXP3 Gene Expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans invasion Neoplasm Invasiveness Neoplasm Metastasis Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism RNA, Small Interfering
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