Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells

Highlights • Boswellia ovalifoliolata (BL EthOH) showed cytotoxic activity against TNBC cells. • Cytotoxic activity of BL EthOH was found to be executed through NF-κB inhibition. • BL EthOH showed synergetic chemosensitivity with Cisplatin and Doxorubicin.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Environmental toxicology and pharmacology 2014-07, Vol.38 (1), p.58-70
Hauptverfasser:	Thummuri, Dinesh, Jeengar, Manish Kumar, Shrivastava, Shweta, Areti, Aparna, Yerra, Veera Ganesh, Yamjala, Samyuktha, Komirishetty, Prashanth, Naidu, V.G.M, Kumar, Ashutosh, Sistla, Ramakrishna
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Boswellia Boswellia ovalifoliolata Caspase 3 - metabolism Cell Cycle - drug effects Cell Line, Tumor Cell Survival - drug effects Chemoresistance DNA Fragmentation Drug Resistance, Neoplasm Emergency Female Humans NF-kappa B - metabolism NF-κB Plant Extracts - pharmacology Plant Leaves Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive Oxygen Species - metabolism ROS S-phase TNBC Triple Negative Breast Neoplasms
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Boswellia ovalifoliolata (BL EthOH) showed cytotoxic activity against TNBC cells. • Cytotoxic activity of BL EthOH was found to be executed through NF-κB inhibition. • BL EthOH showed synergetic chemosensitivity with Cisplatin and Doxorubicin.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2014.05.002