Selenadiazole derivatives as potent thioredoxin reductase inhibitors that enhance the radiosensitivity of cancer cells

Thioredoxin system is an attractive target to overcome radioresistance in cancer therapy. The redox enzyme thioredoxin reductase (TrxR) plays a vital role in restoring cellular thiol redox balance disrupted by radiation-induced reactive oxygens species (ROS) generation and oxidative damage. In this...

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Veröffentlicht in:	European journal of medicinal chemistry 2014-09, Vol.84, p.335-342
Hauptverfasser:	Liang, Yuan-Wei, Zheng, Junsheng, Li, Xiaoling, Zheng, Wenjie, Chen, Tianfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Azoles - chemical synthesis Azoles - chemistry Azoles - pharmacology Cell Survival - drug effects Dose-Response Relationship, Drug Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Gamma Rays Humans Molecular Structure Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - pathology Neoplasms - radiotherapy Organoselenium Compounds - chemical synthesis Organoselenium Compounds - chemistry Organoselenium Compounds - pharmacology Radiation Tolerance - drug effects Radiation-Sensitizing Agents - chemical synthesis Radiation-Sensitizing Agents - chemistry Radiation-Sensitizing Agents - pharmacology Radiosensitization Reactive Oxygen Species - metabolism ROS Selenadiazole Structure-Activity Relationship Thioredoxin reductase Thioredoxin-Disulfide Reductase - antagonists & inhibitors Thioredoxin-Disulfide Reductase - metabolism Tumor Cells, Cultured
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