Nitric oxide increases the invasion of pancreatic cancer cells via activation of the PI3K–AKT and RhoA pathways after carbon ion irradiation

•PANC-1 cell invasion and NO production were increased by carbon ion irradiation.•NO produced by invading PANC-1 cells activated the PI3K–AKT and RhoA signaling pathways.•PANC-1 invasion was suppressed by inhibiting PI3K, ROCK, serine protease, and/or NOS. Previous studies have shown that serine pro...

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Veröffentlicht in:	FEBS letters 2014-08, Vol.588 (17), p.3240-3250
Hauptverfasser:	Fujita, Mayumi, Imadome, Kaori, Endo, Satoshi, Shoji, Yoshimi, Yamada, Shigeru, Imai, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	4′,6-diamidino-2-phenylindole Cell Line, Tumor DAF-2 DAF-2DA DAPI diaminofluorescein-2 diaminofluorescein-2 diacetate DMEM DNA Damage - radiation effects Dulbecco's modified Eagle's medium ECM Enzyme Activation - radiation effects extracellular matrix Gene Expression Regulation, Neoplastic - radiation effects GSNO Heavy Ion Radiotherapy Humans Invasion Krebs–Ringer phosphate KRP l-NMMA matrix metalloproteinase Mesenchymal–amoeboid MMP Neoplasm Invasiveness NG monomethyl-l-arginine nitric oxide Nitric Oxide - biosynthesis Nitric Oxide - metabolism Nitric oxide synthase Nitric Oxide Synthase - metabolism nitrite NO2 NOS Pancreatic Neoplasms - pathology PBS PCR phosphate-buffered saline Phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - metabolism PI3K Plasminogen activator polymerase chain reaction Proto-Oncogene Proteins c-akt - metabolism Rho Rho-associated coiled-coil-forming protein kinase rhoA GTP-Binding Protein - metabolism ROCK S-nitrosoglutathione Signal Transduction - radiation effects uPA urokinase-type plasminogen activator v-akt murine thymoma viral oncogene homolog 2
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