miR-342-3p suppresses proliferation, migration and invasion by targeting FOXM1 in human cervical cancer
•We reported that FOXM1 was directly targeted by miR-342-3p.•miR-342-3p inhibits cell proliferation, migration and invasion in cervical cells.•miR-342-3p is down-regulated along with its host gene, EVL, in human cervical cancer.•FOXM1 is upregulated and negatively correlates with miR-342-3p in cervi...
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| Veröffentlicht in: | FEBS letters 2014-08, Vol.588 (17), p.3298-3307 |
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| creator | Li, Xu-ri Chu, Hui-jun Lv, Teng Wang, Lei Kong, Shou-fang Dai, Shu-zhen |
| description | •We reported that FOXM1 was directly targeted by miR-342-3p.•miR-342-3p inhibits cell proliferation, migration and invasion in cervical cells.•miR-342-3p is down-regulated along with its host gene, EVL, in human cervical cancer.•FOXM1 is upregulated and negatively correlates with miR-342-3p in cervical cancer.
FOXM1 is a well-established oncogenic factor that has been reported to be involved in multiple biological processes including cell proliferation, growth, angiogenesis, migration and invasion. It can also be regulated by miRNAs. In this study, we reported that FOXM1 is directly targeted by miR-342-3p, which is down-regulated along with its host gene, EVL, in human cervical cancer tissues compared to the adjacent normal tissues. Functional studies suggested that the overexpression of miR-342-3p inhibits cell proliferation, migration and invasion in cervical cell lines. FOXM1 is upregulated and negatively correlates with miR-342-3p in cervical cancer tissues, and the overexpression of FOXM1 rescues the phenotype changes induced by the overexpression of miR-342-3p. |
| doi_str_mv | 10.1016/j.febslet.2014.07.020 |
| format | Article |
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FOXM1 is a well-established oncogenic factor that has been reported to be involved in multiple biological processes including cell proliferation, growth, angiogenesis, migration and invasion. It can also be regulated by miRNAs. In this study, we reported that FOXM1 is directly targeted by miR-342-3p, which is down-regulated along with its host gene, EVL, in human cervical cancer tissues compared to the adjacent normal tissues. Functional studies suggested that the overexpression of miR-342-3p inhibits cell proliferation, migration and invasion in cervical cell lines. FOXM1 is upregulated and negatively correlates with miR-342-3p in cervical cancer tissues, and the overexpression of FOXM1 rescues the phenotype changes induced by the overexpression of miR-342-3p.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2014.07.020</identifier><identifier>PMID: 25066298</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adult ; Base Sequence ; Cell Line, Tumor ; Cell Movement - genetics ; Cell Proliferation ; Cervical cancer ; Down-Regulation - genetics ; EVL ; Female ; Forkhead Box M1 ; Forkhead Box Protein M1 ; Forkhead Transcription Factors - genetics ; Humans ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Middle Aged ; miR-342-3p ; Neoplasm Invasiveness - genetics ; Phenotype ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - pathology</subject><ispartof>FEBS letters, 2014-08, Vol.588 (17), p.3298-3307</ispartof><rights>2014</rights><rights>FEBS Letters 588 (2014) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright © 2014. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5669-81b9c2501178e8d0e6d096dae602868f3de3d15c012c19c1affb40f5881c156e3</citedby><cites>FETCH-LOGICAL-c5669-81b9c2501178e8d0e6d096dae602868f3de3d15c012c19c1affb40f5881c156e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2014.07.020$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579314005699$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,3537,27901,27902,45550,45551,46384,46808,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25066298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xu-ri</creatorcontrib><creatorcontrib>Chu, Hui-jun</creatorcontrib><creatorcontrib>Lv, Teng</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Kong, Shou-fang</creatorcontrib><creatorcontrib>Dai, Shu-zhen</creatorcontrib><title>miR-342-3p suppresses proliferation, migration and invasion by targeting FOXM1 in human cervical cancer</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>•We reported that FOXM1 was directly targeted by miR-342-3p.•miR-342-3p inhibits cell proliferation, migration and invasion in cervical cells.•miR-342-3p is down-regulated along with its host gene, EVL, in human cervical cancer.•FOXM1 is upregulated and negatively correlates with miR-342-3p in cervical cancer.
FOXM1 is a well-established oncogenic factor that has been reported to be involved in multiple biological processes including cell proliferation, growth, angiogenesis, migration and invasion. It can also be regulated by miRNAs. In this study, we reported that FOXM1 is directly targeted by miR-342-3p, which is down-regulated along with its host gene, EVL, in human cervical cancer tissues compared to the adjacent normal tissues. Functional studies suggested that the overexpression of miR-342-3p inhibits cell proliferation, migration and invasion in cervical cell lines. FOXM1 is upregulated and negatively correlates with miR-342-3p in cervical cancer tissues, and the overexpression of FOXM1 rescues the phenotype changes induced by the overexpression of miR-342-3p.</description><subject>Adult</subject><subject>Base Sequence</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation</subject><subject>Cervical cancer</subject><subject>Down-Regulation - genetics</subject><subject>EVL</subject><subject>Female</subject><subject>Forkhead Box M1</subject><subject>Forkhead Box Protein M1</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Humans</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>miR-342-3p</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Phenotype</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvpTwD5yIEEjxM7zgnRqttWKqoErdSb5TiTxat8YSeL9t_jKAtXOHlG884742cIeQcsBQby0z5tsAotTilnkKesSBlnL8gGVJElWS7VS7JhsZKIoszOyJsQ9izmCsrX5IwLJiUv1YbsOvctynmSjTTM4-gxBAx09EPrGvRmckP_kXZut4bU9DV1_cGEJamOdDJ-h5Prd3T78PwVYo3-mDvTU4v-4KxpqTV9jN-SV41pA16c3nPytL1-vLpN7h9u7q6-3CdWSFkmCqrSxu0ACoWqZihrVsraoGRcSdVkNWY1CMuAWygtmKapctYIpcCCkJidkw-rb_zBzxnDpDsXLLat6XGYgwYh8lzyDPIoFavU-iEEj40eveuMP2pgemGs9_rEWC-MNSt0ZBz73p9GzFWH9d-uP1Cj4HYV_HItHv_PVW-vL_n35WDLvSBnTMiyjFafVyuMzA4OvQ7WYQRaO4920vXg_rHtb1svpNk</recordid><startdate>20140825</startdate><enddate>20140825</enddate><creator>Li, Xu-ri</creator><creator>Chu, Hui-jun</creator><creator>Lv, Teng</creator><creator>Wang, Lei</creator><creator>Kong, Shou-fang</creator><creator>Dai, Shu-zhen</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140825</creationdate><title>miR-342-3p suppresses proliferation, migration and invasion by targeting FOXM1 in human cervical cancer</title><author>Li, Xu-ri ; Chu, Hui-jun ; Lv, Teng ; Wang, Lei ; Kong, Shou-fang ; Dai, Shu-zhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5669-81b9c2501178e8d0e6d096dae602868f3de3d15c012c19c1affb40f5881c156e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Base Sequence</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation</topic><topic>Cervical cancer</topic><topic>Down-Regulation - genetics</topic><topic>EVL</topic><topic>Female</topic><topic>Forkhead Box M1</topic><topic>Forkhead Box Protein M1</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>Humans</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Middle Aged</topic><topic>miR-342-3p</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Phenotype</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xu-ri</creatorcontrib><creatorcontrib>Chu, Hui-jun</creatorcontrib><creatorcontrib>Lv, Teng</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Kong, Shou-fang</creatorcontrib><creatorcontrib>Dai, Shu-zhen</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xu-ri</au><au>Chu, Hui-jun</au><au>Lv, Teng</au><au>Wang, Lei</au><au>Kong, Shou-fang</au><au>Dai, Shu-zhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>miR-342-3p suppresses proliferation, migration and invasion by targeting FOXM1 in human cervical cancer</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2014-08-25</date><risdate>2014</risdate><volume>588</volume><issue>17</issue><spage>3298</spage><epage>3307</epage><pages>3298-3307</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>•We reported that FOXM1 was directly targeted by miR-342-3p.•miR-342-3p inhibits cell proliferation, migration and invasion in cervical cells.•miR-342-3p is down-regulated along with its host gene, EVL, in human cervical cancer.•FOXM1 is upregulated and negatively correlates with miR-342-3p in cervical cancer.
FOXM1 is a well-established oncogenic factor that has been reported to be involved in multiple biological processes including cell proliferation, growth, angiogenesis, migration and invasion. It can also be regulated by miRNAs. In this study, we reported that FOXM1 is directly targeted by miR-342-3p, which is down-regulated along with its host gene, EVL, in human cervical cancer tissues compared to the adjacent normal tissues. Functional studies suggested that the overexpression of miR-342-3p inhibits cell proliferation, migration and invasion in cervical cell lines. FOXM1 is upregulated and negatively correlates with miR-342-3p in cervical cancer tissues, and the overexpression of FOXM1 rescues the phenotype changes induced by the overexpression of miR-342-3p.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>25066298</pmid><doi>10.1016/j.febslet.2014.07.020</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Base Sequence Cell Line, Tumor Cell Movement - genetics Cell Proliferation Cervical cancer Down-Regulation - genetics EVL Female Forkhead Box M1 Forkhead Box Protein M1 Forkhead Transcription Factors - genetics Humans MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR-342-3p Neoplasm Invasiveness - genetics Phenotype Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology |
| title | miR-342-3p suppresses proliferation, migration and invasion by targeting FOXM1 in human cervical cancer |
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