Studies of the chronic toxicity of tetrandrine in dogs: An inhibitor of silicosis
Dogs administered tetrandrine at low dose (3 mg/kg) and medium dose (10 mg/kg) levels showed no toxic changes. Administration of the drug at a high dose level (40 mg/kg) for 2 months may induce focal necrosis of liver cells, abnormal liver function, and acceleration of erythrocyte sedimentation rate...
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| Veröffentlicht in: | Ecotoxicology and environmental safety 1982-01, Vol.6 (6), p.528-534 |
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| container_issue | 6 |
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| container_title | Ecotoxicology and environmental safety |
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| creator | Tainlin, Li Tingyi, Hu Changqi, Zou Peipei, Yao Qiong, Zheng |
| description | Dogs administered tetrandrine at low dose (3 mg/kg) and medium dose (10 mg/kg) levels showed no toxic changes. Administration of the drug at a high dose level (40 mg/kg) for 2 months may induce focal necrosis of liver cells, abnormal liver function, and acceleration of erythrocyte sedimentation rate. After the dogs had received tetrandrine for 6 months continuously, necrosis of liver tissue appeared. After continuous administration of tetrandrine, accumulation of the drug in liver, lung, kidney, and adrenal gland was observed. The amount of drug stored in the organs increased with the quantity of drug given to the animal. |
| doi_str_mv | 10.1016/0147-6513(82)90034-3 |
| format | Article |
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Administration of the drug at a high dose level (40 mg/kg) for 2 months may induce focal necrosis of liver cells, abnormal liver function, and acceleration of erythrocyte sedimentation rate. After the dogs had received tetrandrine for 6 months continuously, necrosis of liver tissue appeared. After continuous administration of tetrandrine, accumulation of the drug in liver, lung, kidney, and adrenal gland was observed. The amount of drug stored in the organs increased with the quantity of drug given to the animal.</description><identifier>ISSN: 0147-6513</identifier><identifier>EISSN: 1090-2414</identifier><identifier>DOI: 10.1016/0147-6513(82)90034-3</identifier><identifier>PMID: 7169044</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Alkaloids - metabolism ; Alkaloids - therapeutic use ; Alkaloids - toxicity ; Animals ; Benzylisoquinolines ; Blood Sedimentation ; Dogs ; Dose-Response Relationship, Drug ; Liver - drug effects ; Silicosis - prevention & control</subject><ispartof>Ecotoxicology and environmental safety, 1982-01, Vol.6 (6), p.528-534</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-e1781023613ea0f133d6ff7b9b16e2c23f5feda9b109724ffe1f495773bb0cb3</citedby><cites>FETCH-LOGICAL-c411t-e1781023613ea0f133d6ff7b9b16e2c23f5feda9b109724ffe1f495773bb0cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0147-6513(82)90034-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7169044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tainlin, Li</creatorcontrib><creatorcontrib>Tingyi, Hu</creatorcontrib><creatorcontrib>Changqi, Zou</creatorcontrib><creatorcontrib>Peipei, Yao</creatorcontrib><creatorcontrib>Qiong, Zheng</creatorcontrib><title>Studies of the chronic toxicity of tetrandrine in dogs: An inhibitor of silicosis</title><title>Ecotoxicology and environmental safety</title><addtitle>Ecotoxicol Environ Saf</addtitle><description>Dogs administered tetrandrine at low dose (3 mg/kg) and medium dose (10 mg/kg) levels showed no toxic changes. Administration of the drug at a high dose level (40 mg/kg) for 2 months may induce focal necrosis of liver cells, abnormal liver function, and acceleration of erythrocyte sedimentation rate. After the dogs had received tetrandrine for 6 months continuously, necrosis of liver tissue appeared. After continuous administration of tetrandrine, accumulation of the drug in liver, lung, kidney, and adrenal gland was observed. The amount of drug stored in the organs increased with the quantity of drug given to the animal.</description><subject>Alkaloids - metabolism</subject><subject>Alkaloids - therapeutic use</subject><subject>Alkaloids - toxicity</subject><subject>Animals</subject><subject>Benzylisoquinolines</subject><subject>Blood Sedimentation</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Liver - drug effects</subject><subject>Silicosis - prevention & control</subject><issn>0147-6513</issn><issn>1090-2414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtP3DAQgK2KChbaf1BQTggOaWdiO9lwQFqt-pKQEIKercQZs4N2Y7Ad1P33TdgVx57m9c1o9AnxBeErApbfAFWVlxrlxby4rAGkyuUHMUOoIS8UqgMxe0eOxHGMTzBCoPWhOKywrEGpmbi7T0PHFDPvsrSizK6C79lmyf9ly2n71qcUmr4L3FPGfdb5x3iVLfoxX3HLyYcJirxm6yPHT-Kja9aRPu_jiXj48f1h-Su_uf35e7m4ya1CTDlhNUcoZImSGnAoZVc6V7V1iyUVtpBOO-qasYS6KpRzhE7Vuqpk24Jt5Yk43519Dv5loJjMhqOl9brpyQ_RoNYKNFYjqHagDT7GQM48B940YWsQzCTSTJbMZMnMC_Mm0shx7XR_f2g31L0v7c2N87Pd3DXeNI-Bo_lzj_VcQq2lLibgegfQKOGVKZhomXpLHQeyyXSe___BP_4BiuA</recordid><startdate>19820101</startdate><enddate>19820101</enddate><creator>Tainlin, Li</creator><creator>Tingyi, Hu</creator><creator>Changqi, Zou</creator><creator>Peipei, Yao</creator><creator>Qiong, Zheng</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19820101</creationdate><title>Studies of the chronic toxicity of tetrandrine in dogs: An inhibitor of silicosis</title><author>Tainlin, Li ; Tingyi, Hu ; Changqi, Zou ; Peipei, Yao ; Qiong, Zheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-e1781023613ea0f133d6ff7b9b16e2c23f5feda9b109724ffe1f495773bb0cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Alkaloids - metabolism</topic><topic>Alkaloids - therapeutic use</topic><topic>Alkaloids - toxicity</topic><topic>Animals</topic><topic>Benzylisoquinolines</topic><topic>Blood Sedimentation</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>Liver - drug effects</topic><topic>Silicosis - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tainlin, Li</creatorcontrib><creatorcontrib>Tingyi, Hu</creatorcontrib><creatorcontrib>Changqi, Zou</creatorcontrib><creatorcontrib>Peipei, Yao</creatorcontrib><creatorcontrib>Qiong, Zheng</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Ecotoxicology and environmental safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tainlin, Li</au><au>Tingyi, Hu</au><au>Changqi, Zou</au><au>Peipei, Yao</au><au>Qiong, Zheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies of the chronic toxicity of tetrandrine in dogs: An inhibitor of silicosis</atitle><jtitle>Ecotoxicology and environmental safety</jtitle><addtitle>Ecotoxicol Environ Saf</addtitle><date>1982-01-01</date><risdate>1982</risdate><volume>6</volume><issue>6</issue><spage>528</spage><epage>534</epage><pages>528-534</pages><issn>0147-6513</issn><eissn>1090-2414</eissn><abstract>Dogs administered tetrandrine at low dose (3 mg/kg) and medium dose (10 mg/kg) levels showed no toxic changes. 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| fulltext | fulltext |
| identifier | ISSN: 0147-6513 |
| ispartof | Ecotoxicology and environmental safety, 1982-01, Vol.6 (6), p.528-534 |
| issn | 0147-6513 1090-2414 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alkaloids - metabolism Alkaloids - therapeutic use Alkaloids - toxicity Animals Benzylisoquinolines Blood Sedimentation Dogs Dose-Response Relationship, Drug Liver - drug effects Silicosis - prevention & control |
| title | Studies of the chronic toxicity of tetrandrine in dogs: An inhibitor of silicosis |
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