Coenzyme Q10 supplementation in infertile men with low-grade varicocele: an open, uncontrolled pilot study
Summary Many conditions associated with male infertility are inducers of oxidative stress, including varicocele. Antioxidants, such as coenzyme Q10, may be useful in this case. To evaluate the antioxidant capacity of seminal plasma of infertile men with varicocele before and after an oral supplement...
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| Veröffentlicht in: | Andrologia 2014-09, Vol.46 (7), p.805-807 |
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| container_title | Andrologia |
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| creator | Festa, R. Giacchi, E. Raimondo, S. Tiano, L. Zuccarelli, P. Silvestrini, A. Meucci, E. Littarru, G. P. Mancini, A. |
| description | Summary
Many conditions associated with male infertility are inducers of oxidative stress, including varicocele. Antioxidants, such as coenzyme Q10, may be useful in this case. To evaluate the antioxidant capacity of seminal plasma of infertile men with varicocele before and after an oral supplementation with coenzyme Q10, 38 patients were recruited from a pilot clinical trial. A standard semen analysis was also performed at baseline and 3 months after an oral supplementation with exogenous coenzyme Q10 100 mg per die. Seminal plasma antioxidant capacity was measured using a spectroscopic method. Coenzyme Q10 therapy improved semen parameters and antioxidant status. This study highlights the importance of oxidative stress in the pathogenesis of male infertility, namely in varicocele, and strengthens the possibility of the usefulness of the antioxidant therapy. |
| doi_str_mv | 10.1111/and.12152 |
| format | Article |
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Many conditions associated with male infertility are inducers of oxidative stress, including varicocele. Antioxidants, such as coenzyme Q10, may be useful in this case. To evaluate the antioxidant capacity of seminal plasma of infertile men with varicocele before and after an oral supplementation with coenzyme Q10, 38 patients were recruited from a pilot clinical trial. A standard semen analysis was also performed at baseline and 3 months after an oral supplementation with exogenous coenzyme Q10 100 mg per die. Seminal plasma antioxidant capacity was measured using a spectroscopic method. Coenzyme Q10 therapy improved semen parameters and antioxidant status. This study highlights the importance of oxidative stress in the pathogenesis of male infertility, namely in varicocele, and strengthens the possibility of the usefulness of the antioxidant therapy.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.12152</identifier><identifier>PMID: 23964789</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Antioxidants ; coenzyme Q10 ; Dietary Supplements ; Humans ; Infertility, Male - drug therapy ; Infertility, Male - etiology ; Male ; male infertility ; oxidative stress ; Pilot Projects ; Ubiquinone - administration & dosage ; Ubiquinone - analogs & derivatives ; varicocele ; Varicocele - complications</subject><ispartof>Andrologia, 2014-09, Vol.46 (7), p.805-807</ispartof><rights>2013 Blackwell Verlag GmbH</rights><rights>2013 Blackwell Verlag GmbH.</rights><rights>Copyright © 2014 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.12152$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.12152$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23964789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Festa, R.</creatorcontrib><creatorcontrib>Giacchi, E.</creatorcontrib><creatorcontrib>Raimondo, S.</creatorcontrib><creatorcontrib>Tiano, L.</creatorcontrib><creatorcontrib>Zuccarelli, P.</creatorcontrib><creatorcontrib>Silvestrini, A.</creatorcontrib><creatorcontrib>Meucci, E.</creatorcontrib><creatorcontrib>Littarru, G. P.</creatorcontrib><creatorcontrib>Mancini, A.</creatorcontrib><title>Coenzyme Q10 supplementation in infertile men with low-grade varicocele: an open, uncontrolled pilot study</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Summary
Many conditions associated with male infertility are inducers of oxidative stress, including varicocele. Antioxidants, such as coenzyme Q10, may be useful in this case. To evaluate the antioxidant capacity of seminal plasma of infertile men with varicocele before and after an oral supplementation with coenzyme Q10, 38 patients were recruited from a pilot clinical trial. A standard semen analysis was also performed at baseline and 3 months after an oral supplementation with exogenous coenzyme Q10 100 mg per die. Seminal plasma antioxidant capacity was measured using a spectroscopic method. Coenzyme Q10 therapy improved semen parameters and antioxidant status. This study highlights the importance of oxidative stress in the pathogenesis of male infertility, namely in varicocele, and strengthens the possibility of the usefulness of the antioxidant therapy.</description><subject>Antioxidants</subject><subject>coenzyme Q10</subject><subject>Dietary Supplements</subject><subject>Humans</subject><subject>Infertility, Male - drug therapy</subject><subject>Infertility, Male - etiology</subject><subject>Male</subject><subject>male infertility</subject><subject>oxidative stress</subject><subject>Pilot Projects</subject><subject>Ubiquinone - administration & dosage</subject><subject>Ubiquinone - analogs & derivatives</subject><subject>varicocele</subject><subject>Varicocele - complications</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1P3DAQhi1EBSvKoX8AWeLCoQF_xmtuaGmhAm1VqS1Hy0kc6q1jB9vpdvvra3Yph44szcjzvKPRvAC8w-gcl7jQvjvHBHOyB2aYUVkhIsg-mCGKaMV4LQ_BcUorVIJxIRg7AIeEypqJuZyB1SIY_2czGPgFI5imcXRmMD7rbIOH9vn1JmbrDCzfcG3zD-jCunqMujPwl462Da1x5hJqD8No_Hs4-Tb4HINzpoOjdSHDlKdu8xa86bVL5vglH4FvHz98XdxW959vPi2u7itLKCFVgxpDeikaVHMsOqJFyykVtMc1kVrXUvSSzYVuMeeE466UDAlK2raeNx2m9Aic7eaOMTxNJmU12FR2dNqbMCVVdFRgQigr6Ol_6CpM0ZftthRFiMh5oU5eqKkZTKfGaAcdN-rfFQtwsQPW5U6b1z5G6tkhVRxSW4fU1fJ6WxRFtVPYlM3vV4WOP1UtqODqYXmjbr_fXSN0t1QP9C-HmpBp</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Festa, R.</creator><creator>Giacchi, E.</creator><creator>Raimondo, S.</creator><creator>Tiano, L.</creator><creator>Zuccarelli, P.</creator><creator>Silvestrini, A.</creator><creator>Meucci, E.</creator><creator>Littarru, G. P.</creator><creator>Mancini, A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201409</creationdate><title>Coenzyme Q10 supplementation in infertile men with low-grade varicocele: an open, uncontrolled pilot study</title><author>Festa, R. ; Giacchi, E. ; Raimondo, S. ; Tiano, L. ; Zuccarelli, P. ; Silvestrini, A. ; Meucci, E. ; Littarru, G. P. ; Mancini, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2322-b0be2f97b06517d2a7c53373f1629aa697f9487ac155251d87a40732cc68bd133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antioxidants</topic><topic>coenzyme Q10</topic><topic>Dietary Supplements</topic><topic>Humans</topic><topic>Infertility, Male - drug therapy</topic><topic>Infertility, Male - etiology</topic><topic>Male</topic><topic>male infertility</topic><topic>oxidative stress</topic><topic>Pilot Projects</topic><topic>Ubiquinone - administration & dosage</topic><topic>Ubiquinone - analogs & derivatives</topic><topic>varicocele</topic><topic>Varicocele - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Festa, R.</creatorcontrib><creatorcontrib>Giacchi, E.</creatorcontrib><creatorcontrib>Raimondo, S.</creatorcontrib><creatorcontrib>Tiano, L.</creatorcontrib><creatorcontrib>Zuccarelli, P.</creatorcontrib><creatorcontrib>Silvestrini, A.</creatorcontrib><creatorcontrib>Meucci, E.</creatorcontrib><creatorcontrib>Littarru, G. P.</creatorcontrib><creatorcontrib>Mancini, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Festa, R.</au><au>Giacchi, E.</au><au>Raimondo, S.</au><au>Tiano, L.</au><au>Zuccarelli, P.</au><au>Silvestrini, A.</au><au>Meucci, E.</au><au>Littarru, G. P.</au><au>Mancini, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coenzyme Q10 supplementation in infertile men with low-grade varicocele: an open, uncontrolled pilot study</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2014-09</date><risdate>2014</risdate><volume>46</volume><issue>7</issue><spage>805</spage><epage>807</epage><pages>805-807</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>Summary
Many conditions associated with male infertility are inducers of oxidative stress, including varicocele. Antioxidants, such as coenzyme Q10, may be useful in this case. To evaluate the antioxidant capacity of seminal plasma of infertile men with varicocele before and after an oral supplementation with coenzyme Q10, 38 patients were recruited from a pilot clinical trial. A standard semen analysis was also performed at baseline and 3 months after an oral supplementation with exogenous coenzyme Q10 100 mg per die. Seminal plasma antioxidant capacity was measured using a spectroscopic method. Coenzyme Q10 therapy improved semen parameters and antioxidant status. This study highlights the importance of oxidative stress in the pathogenesis of male infertility, namely in varicocele, and strengthens the possibility of the usefulness of the antioxidant therapy.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>23964789</pmid><doi>10.1111/and.12152</doi><tpages>3</tpages></addata></record> |
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| subjects | Antioxidants coenzyme Q10 Dietary Supplements Humans Infertility, Male - drug therapy Infertility, Male - etiology Male male infertility oxidative stress Pilot Projects Ubiquinone - administration & dosage Ubiquinone - analogs & derivatives varicocele Varicocele - complications |
| title | Coenzyme Q10 supplementation in infertile men with low-grade varicocele: an open, uncontrolled pilot study |
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