Blueberries prevent the effect of intermittent hypobaric hypoxia in rat epididymis
Summary Intermittent hypobaric hypoxia (IHH) induced a decrease in sperm count and oxidative damage in epididymis. We have previously demonstrated that a blueberry‐enriched polyphenol extract (BB‐4) reduced the adverse effects of oxidative stress in rat testis under hypobaric hypoxia. The aim of thi...
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| Veröffentlicht in: | Andrologia 2014-09, Vol.46 (7), p.766-769 |
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| container_title | Andrologia |
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| creator | Zepeda, A. B. Calaf, G. M. Figueroa, C. A. Farías, J. G. |
| description | Summary
Intermittent hypobaric hypoxia (IHH) induced a decrease in sperm count and oxidative damage in epididymis. We have previously demonstrated that a blueberry‐enriched polyphenol extract (BB‐4) reduced the adverse effects of oxidative stress in rat testis under hypobaric hypoxia. The aim of this study was to evaluate whether BB‐4 could reverse oxidative stress in epididymis. To evaluate the protective role of BB‐4 in epididymis, male rats were exposed to IHH. Lipid peroxidation, (LPO) expression and activity of glutathione reductase (GR) were evaluated. Our results showed a reduction in LPO and a decrease in GR activity in rat epididymis exposed to IHH. These results suggest that BB‐4 can prevent the effects of IHH in rat epididymis. |
| doi_str_mv | 10.1111/and.12146 |
| format | Article |
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Intermittent hypobaric hypoxia (IHH) induced a decrease in sperm count and oxidative damage in epididymis. We have previously demonstrated that a blueberry‐enriched polyphenol extract (BB‐4) reduced the adverse effects of oxidative stress in rat testis under hypobaric hypoxia. The aim of this study was to evaluate whether BB‐4 could reverse oxidative stress in epididymis. To evaluate the protective role of BB‐4 in epididymis, male rats were exposed to IHH. Lipid peroxidation, (LPO) expression and activity of glutathione reductase (GR) were evaluated. Our results showed a reduction in LPO and a decrease in GR activity in rat epididymis exposed to IHH. These results suggest that BB‐4 can prevent the effects of IHH in rat epididymis.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.12146</identifier><identifier>PMID: 23957290</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Animals ; Antioxidants ; Blueberry Plants ; Epididymis ; Epididymis - pathology ; hypobaric hypoxia ; Hypoxia ; Hypoxia - prevention & control ; infertility ; Lipid Peroxidation ; Male ; Oxidative stress ; polyphenols ; Rats ; Rodents ; Thiobarbituric Acid Reactive Substances - metabolism</subject><ispartof>Andrologia, 2014-09, Vol.46 (7), p.766-769</ispartof><rights>2013 Blackwell Verlag GmbH</rights><rights>2013 Blackwell Verlag GmbH.</rights><rights>Copyright © 2014 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4266-cf740b8091926da69f114577ac50886c8b744e202baec011dfce783aa5d0bdac3</citedby><cites>FETCH-LOGICAL-c4266-cf740b8091926da69f114577ac50886c8b744e202baec011dfce783aa5d0bdac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.12146$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.12146$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23957290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zepeda, A. B.</creatorcontrib><creatorcontrib>Calaf, G. M.</creatorcontrib><creatorcontrib>Figueroa, C. A.</creatorcontrib><creatorcontrib>Farías, J. G.</creatorcontrib><title>Blueberries prevent the effect of intermittent hypobaric hypoxia in rat epididymis</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Summary
Intermittent hypobaric hypoxia (IHH) induced a decrease in sperm count and oxidative damage in epididymis. We have previously demonstrated that a blueberry‐enriched polyphenol extract (BB‐4) reduced the adverse effects of oxidative stress in rat testis under hypobaric hypoxia. The aim of this study was to evaluate whether BB‐4 could reverse oxidative stress in epididymis. To evaluate the protective role of BB‐4 in epididymis, male rats were exposed to IHH. Lipid peroxidation, (LPO) expression and activity of glutathione reductase (GR) were evaluated. Our results showed a reduction in LPO and a decrease in GR activity in rat epididymis exposed to IHH. These results suggest that BB‐4 can prevent the effects of IHH in rat epididymis.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Blueberry Plants</subject><subject>Epididymis</subject><subject>Epididymis - pathology</subject><subject>hypobaric hypoxia</subject><subject>Hypoxia</subject><subject>Hypoxia - prevention & control</subject><subject>infertility</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Oxidative stress</subject><subject>polyphenols</subject><subject>Rats</subject><subject>Rodents</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LxDAQhoMouqgH_4AUvOihmo8maY9-rygriuIxpOkUo922Jqm6_97srnoQnMsMzDPvvLwI7RB8SGId6bY6JJRkYgWNSMaKFFNJV9EIM8zSjItiA217_4JjZVzKLFtHG5QVXNICj9D9STNACc5Z8Env4B3akIRnSKCuwYSkqxPbBnBTG8J89Tzru1I7axbTp9VxnTgdEuhtZavZ1PottFbrxsP2d99EjxfnD6fj9Ob28ur0-CY1GRUiNbXMcJnjghRUVFoUNSFzg9pwnOfC5GX0ChTTUoPBhFS1AZkzrXmFy0obton2l7q9694G8EHF5waaRrfQDV4RzpkkFEsS0b0_6Es3uDa6W1AsZkNwpA6WlHGd9w5q1Ts71W6mCFbzrFXMWi2yjuzut-JQTqH6JX-SjcDREviwDcz-V1LHk7MfyXR5YX2Az98L7V6VkExy9TS5VJM7Lq7J-FqN2RezUJac</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Zepeda, A. B.</creator><creator>Calaf, G. M.</creator><creator>Figueroa, C. A.</creator><creator>Farías, J. G.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201409</creationdate><title>Blueberries prevent the effect of intermittent hypobaric hypoxia in rat epididymis</title><author>Zepeda, A. B. ; Calaf, G. M. ; Figueroa, C. A. ; Farías, J. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4266-cf740b8091926da69f114577ac50886c8b744e202baec011dfce783aa5d0bdac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Blueberry Plants</topic><topic>Epididymis</topic><topic>Epididymis - pathology</topic><topic>hypobaric hypoxia</topic><topic>Hypoxia</topic><topic>Hypoxia - prevention & control</topic><topic>infertility</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Oxidative stress</topic><topic>polyphenols</topic><topic>Rats</topic><topic>Rodents</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zepeda, A. B.</creatorcontrib><creatorcontrib>Calaf, G. M.</creatorcontrib><creatorcontrib>Figueroa, C. A.</creatorcontrib><creatorcontrib>Farías, J. G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zepeda, A. B.</au><au>Calaf, G. M.</au><au>Figueroa, C. A.</au><au>Farías, J. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blueberries prevent the effect of intermittent hypobaric hypoxia in rat epididymis</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2014-09</date><risdate>2014</risdate><volume>46</volume><issue>7</issue><spage>766</spage><epage>769</epage><pages>766-769</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>Summary
Intermittent hypobaric hypoxia (IHH) induced a decrease in sperm count and oxidative damage in epididymis. We have previously demonstrated that a blueberry‐enriched polyphenol extract (BB‐4) reduced the adverse effects of oxidative stress in rat testis under hypobaric hypoxia. The aim of this study was to evaluate whether BB‐4 could reverse oxidative stress in epididymis. To evaluate the protective role of BB‐4 in epididymis, male rats were exposed to IHH. Lipid peroxidation, (LPO) expression and activity of glutathione reductase (GR) were evaluated. Our results showed a reduction in LPO and a decrease in GR activity in rat epididymis exposed to IHH. These results suggest that BB‐4 can prevent the effects of IHH in rat epididymis.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>23957290</pmid><doi>10.1111/and.12146</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Antioxidants Blueberry Plants Epididymis Epididymis - pathology hypobaric hypoxia Hypoxia Hypoxia - prevention & control infertility Lipid Peroxidation Male Oxidative stress polyphenols Rats Rodents Thiobarbituric Acid Reactive Substances - metabolism |
| title | Blueberries prevent the effect of intermittent hypobaric hypoxia in rat epididymis |
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