Histochemical and immunohistochemical characteristics of elastofibromas
Elastofibromas are slow-growing and rare soft-tissue tumors. The etiology and pathogenetic mechanisms are still controversial and there are only a few studies in the literature investigating the histochemical, immunohistochemical, and genetic features to determine the pathogenesis. We investigated t...
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| Veröffentlicht in: | Polish journal of pathology 2014-06, Vol.65 (2), p.120-124 |
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| creator | Tasli, F Vardar, E Argon, A Kabat, T Deniz, S Nart, A Kececi, Y |
| description | Elastofibromas are slow-growing and rare soft-tissue tumors. The etiology and pathogenetic mechanisms are still controversial and there are only a few studies in the literature investigating the histochemical, immunohistochemical, and genetic features to determine the pathogenesis. We investigated the cellular composition of lesions with a diagnosis of elastofibroma in 17 patients by using histochemical and immunohistochemical methods. There were 17 cases with a mean age of 53.5 years. Mean lesion diameter was 6.6 cm. The immunohistochemical method showed vimentin and factor XIIIa positivity in all cases. Four cases had focal myoglobin positivity in the spindle-shaped cells between the collagen fibers. Spindle cells were positive for CD34 in 8 cases. Smooth muscle actin, desmin, type 4 collagen and laminin were negative in all cases. The elastic nature of the abnormal fibers was shown histoch with Verhoeff elastin staining and aldehyde fuchsin staining in all cases. Our results have shown that the concurrent positivity of factor XIIIa and CD34 in the cells forming the lesion might show that the lesionoriginates from primitive dermal mesenchymal cells. In addition, the myoglobin positivity found in some cases indicates the possibility of a myofibroblastic origin of elastofibromas. |
| doi_str_mv | 10.5114/pjp.2014.43961 |
| format | Article |
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The etiology and pathogenetic mechanisms are still controversial and there are only a few studies in the literature investigating the histochemical, immunohistochemical, and genetic features to determine the pathogenesis. We investigated the cellular composition of lesions with a diagnosis of elastofibroma in 17 patients by using histochemical and immunohistochemical methods. There were 17 cases with a mean age of 53.5 years. Mean lesion diameter was 6.6 cm. The immunohistochemical method showed vimentin and factor XIIIa positivity in all cases. Four cases had focal myoglobin positivity in the spindle-shaped cells between the collagen fibers. Spindle cells were positive for CD34 in 8 cases. Smooth muscle actin, desmin, type 4 collagen and laminin were negative in all cases. The elastic nature of the abnormal fibers was shown histoch with Verhoeff elastin staining and aldehyde fuchsin staining in all cases. Our results have shown that the concurrent positivity of factor XIIIa and CD34 in the cells forming the lesion might show that the lesionoriginates from primitive dermal mesenchymal cells. In addition, the myoglobin positivity found in some cases indicates the possibility of a myofibroblastic origin of elastofibromas.</description><identifier>ISSN: 1233-9687</identifier><identifier>EISSN: 2084-9869</identifier><identifier>DOI: 10.5114/pjp.2014.43961</identifier><identifier>PMID: 25119171</identifier><language>eng</language><publisher>Poland: Termedia Publishing House</publisher><subject>Adult ; Aged ; Biomarkers, Tumor - analysis ; Biopsy ; Cell Lineage ; Collagen ; Family medical history ; Female ; Fibroblasts ; Fibroma - chemistry ; Fibroma - pathology ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Pathogenesis ; Predictive Value of Tests ; Retrospective Studies ; Smooth muscle ; Soft Tissue Neoplasms - chemistry ; Soft Tissue Neoplasms - pathology ; Tumor Burden</subject><ispartof>Polish journal of pathology, 2014-06, Vol.65 (2), p.120-124</ispartof><rights>2014. This work is published under http://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). 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The etiology and pathogenetic mechanisms are still controversial and there are only a few studies in the literature investigating the histochemical, immunohistochemical, and genetic features to determine the pathogenesis. We investigated the cellular composition of lesions with a diagnosis of elastofibroma in 17 patients by using histochemical and immunohistochemical methods. There were 17 cases with a mean age of 53.5 years. Mean lesion diameter was 6.6 cm. The immunohistochemical method showed vimentin and factor XIIIa positivity in all cases. Four cases had focal myoglobin positivity in the spindle-shaped cells between the collagen fibers. Spindle cells were positive for CD34 in 8 cases. Smooth muscle actin, desmin, type 4 collagen and laminin were negative in all cases. The elastic nature of the abnormal fibers was shown histoch with Verhoeff elastin staining and aldehyde fuchsin staining in all cases. Our results have shown that the concurrent positivity of factor XIIIa and CD34 in the cells forming the lesion might show that the lesionoriginates from primitive dermal mesenchymal cells. 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The etiology and pathogenetic mechanisms are still controversial and there are only a few studies in the literature investigating the histochemical, immunohistochemical, and genetic features to determine the pathogenesis. We investigated the cellular composition of lesions with a diagnosis of elastofibroma in 17 patients by using histochemical and immunohistochemical methods. There were 17 cases with a mean age of 53.5 years. Mean lesion diameter was 6.6 cm. The immunohistochemical method showed vimentin and factor XIIIa positivity in all cases. Four cases had focal myoglobin positivity in the spindle-shaped cells between the collagen fibers. Spindle cells were positive for CD34 in 8 cases. Smooth muscle actin, desmin, type 4 collagen and laminin were negative in all cases. The elastic nature of the abnormal fibers was shown histoch with Verhoeff elastin staining and aldehyde fuchsin staining in all cases. 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| subjects | Adult Aged Biomarkers, Tumor - analysis Biopsy Cell Lineage Collagen Family medical history Female Fibroblasts Fibroma - chemistry Fibroma - pathology Humans Immunohistochemistry Male Middle Aged Pathogenesis Predictive Value of Tests Retrospective Studies Smooth muscle Soft Tissue Neoplasms - chemistry Soft Tissue Neoplasms - pathology Tumor Burden |
| title | Histochemical and immunohistochemical characteristics of elastofibromas |
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