Catalpol provides protective effects against cerebral ischaemia/reperfusion injury in gerbils
Objectives To investigate the protective effect of catalpol on cerebral ischaemia/reperfusion (CI/R) injury in gerbils and further explore the underlying mechanism. Methods A gerbil model of CI/R was prepared by bilateral common carotid occlusion for 10 min followed by 6 h reperfusion. Catalpol (5,...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2014-09, Vol.66 (9), p.1265-1270 |
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| creator | Liu, Yan-ru Li, Peng-wei Suo, Jian-jun Sun, Yan Zhang, Bo-ai Lu, Hong Zhu, Hong-can Zhang, Guo-bin |
| description | Objectives
To investigate the protective effect of catalpol on cerebral ischaemia/reperfusion (CI/R) injury in gerbils and further explore the underlying mechanism.
Methods
A gerbil model of CI/R was prepared by bilateral common carotid occlusion for 10 min followed by 6 h reperfusion. Catalpol (5, 10 or 20 mg/kg per day) was injected intraperitoneally for 3 days before the carotid occlusion. Stroke index was measured during the reperfusion. The contents of endogenous neuropeptides, endothelin‐1 (ET‐1) and calcitonin gene‐related peptide in plasma were evaluated by radioimmunoassay. Superoxide dismutase (SOD) and malondialdehyde (MDA) in brain tissue homogenate were also examined.
Key findings
The results showed that catalpol significantly improved the stroke index compared with CI/R control group (P |
| doi_str_mv | 10.1111/jphp.12261 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1553706061</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3402909531</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5011-71336c8d0d57bbe06b3f70a2b66b27b3cdafdde4ace1381ff820eb49499ba6583</originalsourceid><addsrcrecordid>eNp9kEtP4zAUhS3ECEphww9AkdggpIAfsZ0sUcVjKgQIzWOFLDu5Bpc0CXZSpv9-XAosWHAX957Fd4-ODkL7BJ-QOKez7qk7IZQKsoFGFGc0lYTnm2iEMaUp45Jto50QZhhjKYTYQts0kxTLgo_Qw0T3uu7aOul8u3AVhJXooezdAhKwNqqQ6EftmtAnJXgwXteJC-WThrnTpx468HYIrm0S18wGv4wneQRvXB120Q-r6wB773eMfl-c_5pcpde3lz8nZ9dpyTEhMS5joswrXHFpDGBhmJVYUyOEodKwstK2qiDTJRCWE2tzisFkRVYURgueszE6WvvG7C8DhF7NY0Koa91AOwRFOGcSCyxIRA-_oLN28E1M90ZRRuOO1PGaKn0bggerOu_m2i8VwWpVulqVrt5Kj_DBu-Vg5lB9oh8tR4CsgVdXw_IbKzW9u7r7ME3XPy708O_zR_tnJSSTXP29uVQ3TBZ_xP29mrL_bLqc0Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1553232553</pqid></control><display><type>article</type><title>Catalpol provides protective effects against cerebral ischaemia/reperfusion injury in gerbils</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Liu, Yan-ru ; Li, Peng-wei ; Suo, Jian-jun ; Sun, Yan ; Zhang, Bo-ai ; Lu, Hong ; Zhu, Hong-can ; Zhang, Guo-bin</creator><creatorcontrib>Liu, Yan-ru ; Li, Peng-wei ; Suo, Jian-jun ; Sun, Yan ; Zhang, Bo-ai ; Lu, Hong ; Zhu, Hong-can ; Zhang, Guo-bin</creatorcontrib><description>Objectives
To investigate the protective effect of catalpol on cerebral ischaemia/reperfusion (CI/R) injury in gerbils and further explore the underlying mechanism.
Methods
A gerbil model of CI/R was prepared by bilateral common carotid occlusion for 10 min followed by 6 h reperfusion. Catalpol (5, 10 or 20 mg/kg per day) was injected intraperitoneally for 3 days before the carotid occlusion. Stroke index was measured during the reperfusion. The contents of endogenous neuropeptides, endothelin‐1 (ET‐1) and calcitonin gene‐related peptide in plasma were evaluated by radioimmunoassay. Superoxide dismutase (SOD) and malondialdehyde (MDA) in brain tissue homogenate were also examined.
Key findings
The results showed that catalpol significantly improved the stroke index compared with CI/R control group (P < 0.05 or P < 0.01). Catalpol significantly increased the activity of SOD at the doses of 10 and 20 mg/kg (P ≤ 0.05), decreased the brain MDA content and the plasma level of ET‐1 at the doses of 10 and 20 mg/kg (P ≤ 0.01).
Conclusions
These data suggested that the efficacy of catalpol pretreatment on CI/R injury may be attributed to reduction of free radicals and inhibition of lipid peroxidation and ET‐1 production.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1111/jphp.12261</identifier><identifier>PMID: 24720795</identifier><identifier>CODEN: JPPMAB</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; Brain - drug effects ; Brain - metabolism ; Brain Ischemia - drug therapy ; Brain Ischemia - metabolism ; Calcitonin Gene-Related Peptide - blood ; catalpol ; Cerebral Infarction - drug therapy ; Cerebral Infarction - metabolism ; cerebral ischaemia/reperfusion injury ; Disease Models, Animal ; endothelin-1 ; Endothelin-1 - blood ; Female ; Free radicals ; Free Radicals - metabolism ; Gerbillinae ; Injections, Intraperitoneal ; Iridoid Glucosides - pharmacology ; Iridoid Glucosides - therapeutic use ; Lipid Peroxidation - drug effects ; Male ; malondialdehyde ; Malondialdehyde - metabolism ; Medical research ; Neuropeptides - metabolism ; Oxidative Stress - drug effects ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Rehmannia - chemistry ; Reperfusion Injury - blood ; Reperfusion Injury - metabolism ; Reperfusion Injury - prevention & control ; Rodents ; Stroke - prevention & control ; superoxide dismutase ; Superoxide Dismutase - metabolism</subject><ispartof>Journal of pharmacy and pharmacology, 2014-09, Vol.66 (9), p.1265-1270</ispartof><rights>2014 Royal Pharmaceutical Society</rights><rights>2014 Royal Pharmaceutical Society.</rights><rights>Copyright © 2014 Royal Pharmaceutical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5011-71336c8d0d57bbe06b3f70a2b66b27b3cdafdde4ace1381ff820eb49499ba6583</citedby><cites>FETCH-LOGICAL-c5011-71336c8d0d57bbe06b3f70a2b66b27b3cdafdde4ace1381ff820eb49499ba6583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjphp.12261$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjphp.12261$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24720795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yan-ru</creatorcontrib><creatorcontrib>Li, Peng-wei</creatorcontrib><creatorcontrib>Suo, Jian-jun</creatorcontrib><creatorcontrib>Sun, Yan</creatorcontrib><creatorcontrib>Zhang, Bo-ai</creatorcontrib><creatorcontrib>Lu, Hong</creatorcontrib><creatorcontrib>Zhu, Hong-can</creatorcontrib><creatorcontrib>Zhang, Guo-bin</creatorcontrib><title>Catalpol provides protective effects against cerebral ischaemia/reperfusion injury in gerbils</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>Objectives
To investigate the protective effect of catalpol on cerebral ischaemia/reperfusion (CI/R) injury in gerbils and further explore the underlying mechanism.
Methods
A gerbil model of CI/R was prepared by bilateral common carotid occlusion for 10 min followed by 6 h reperfusion. Catalpol (5, 10 or 20 mg/kg per day) was injected intraperitoneally for 3 days before the carotid occlusion. Stroke index was measured during the reperfusion. The contents of endogenous neuropeptides, endothelin‐1 (ET‐1) and calcitonin gene‐related peptide in plasma were evaluated by radioimmunoassay. Superoxide dismutase (SOD) and malondialdehyde (MDA) in brain tissue homogenate were also examined.
Key findings
The results showed that catalpol significantly improved the stroke index compared with CI/R control group (P < 0.05 or P < 0.01). Catalpol significantly increased the activity of SOD at the doses of 10 and 20 mg/kg (P ≤ 0.05), decreased the brain MDA content and the plasma level of ET‐1 at the doses of 10 and 20 mg/kg (P ≤ 0.01).
Conclusions
These data suggested that the efficacy of catalpol pretreatment on CI/R injury may be attributed to reduction of free radicals and inhibition of lipid peroxidation and ET‐1 production.</description><subject>Animals</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain Ischemia - drug therapy</subject><subject>Brain Ischemia - metabolism</subject><subject>Calcitonin Gene-Related Peptide - blood</subject><subject>catalpol</subject><subject>Cerebral Infarction - drug therapy</subject><subject>Cerebral Infarction - metabolism</subject><subject>cerebral ischaemia/reperfusion injury</subject><subject>Disease Models, Animal</subject><subject>endothelin-1</subject><subject>Endothelin-1 - blood</subject><subject>Female</subject><subject>Free radicals</subject><subject>Free Radicals - metabolism</subject><subject>Gerbillinae</subject><subject>Injections, Intraperitoneal</subject><subject>Iridoid Glucosides - pharmacology</subject><subject>Iridoid Glucosides - therapeutic use</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>malondialdehyde</subject><subject>Malondialdehyde - metabolism</subject><subject>Medical research</subject><subject>Neuropeptides - metabolism</subject><subject>Oxidative Stress - drug effects</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Rehmannia - chemistry</subject><subject>Reperfusion Injury - blood</subject><subject>Reperfusion Injury - metabolism</subject><subject>Reperfusion Injury - prevention & control</subject><subject>Rodents</subject><subject>Stroke - prevention & control</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtP4zAUhS3ECEphww9AkdggpIAfsZ0sUcVjKgQIzWOFLDu5Bpc0CXZSpv9-XAosWHAX957Fd4-ODkL7BJ-QOKez7qk7IZQKsoFGFGc0lYTnm2iEMaUp45Jto50QZhhjKYTYQts0kxTLgo_Qw0T3uu7aOul8u3AVhJXooezdAhKwNqqQ6EftmtAnJXgwXteJC-WThrnTpx468HYIrm0S18wGv4wneQRvXB120Q-r6wB773eMfl-c_5pcpde3lz8nZ9dpyTEhMS5joswrXHFpDGBhmJVYUyOEodKwstK2qiDTJRCWE2tzisFkRVYURgueszE6WvvG7C8DhF7NY0Koa91AOwRFOGcSCyxIRA-_oLN28E1M90ZRRuOO1PGaKn0bggerOu_m2i8VwWpVulqVrt5Kj_DBu-Vg5lB9oh8tR4CsgVdXw_IbKzW9u7r7ME3XPy708O_zR_tnJSSTXP29uVQ3TBZ_xP29mrL_bLqc0Q</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Liu, Yan-ru</creator><creator>Li, Peng-wei</creator><creator>Suo, Jian-jun</creator><creator>Sun, Yan</creator><creator>Zhang, Bo-ai</creator><creator>Lu, Hong</creator><creator>Zhu, Hong-can</creator><creator>Zhang, Guo-bin</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201409</creationdate><title>Catalpol provides protective effects against cerebral ischaemia/reperfusion injury in gerbils</title><author>Liu, Yan-ru ; Li, Peng-wei ; Suo, Jian-jun ; Sun, Yan ; Zhang, Bo-ai ; Lu, Hong ; Zhu, Hong-can ; Zhang, Guo-bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5011-71336c8d0d57bbe06b3f70a2b66b27b3cdafdde4ace1381ff820eb49499ba6583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain Ischemia - drug therapy</topic><topic>Brain Ischemia - metabolism</topic><topic>Calcitonin Gene-Related Peptide - blood</topic><topic>catalpol</topic><topic>Cerebral Infarction - drug therapy</topic><topic>Cerebral Infarction - metabolism</topic><topic>cerebral ischaemia/reperfusion injury</topic><topic>Disease Models, Animal</topic><topic>endothelin-1</topic><topic>Endothelin-1 - blood</topic><topic>Female</topic><topic>Free radicals</topic><topic>Free Radicals - metabolism</topic><topic>Gerbillinae</topic><topic>Injections, Intraperitoneal</topic><topic>Iridoid Glucosides - pharmacology</topic><topic>Iridoid Glucosides - therapeutic use</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>malondialdehyde</topic><topic>Malondialdehyde - metabolism</topic><topic>Medical research</topic><topic>Neuropeptides - metabolism</topic><topic>Oxidative Stress - drug effects</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Rehmannia - chemistry</topic><topic>Reperfusion Injury - blood</topic><topic>Reperfusion Injury - metabolism</topic><topic>Reperfusion Injury - prevention & control</topic><topic>Rodents</topic><topic>Stroke - prevention & control</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yan-ru</creatorcontrib><creatorcontrib>Li, Peng-wei</creatorcontrib><creatorcontrib>Suo, Jian-jun</creatorcontrib><creatorcontrib>Sun, Yan</creatorcontrib><creatorcontrib>Zhang, Bo-ai</creatorcontrib><creatorcontrib>Lu, Hong</creatorcontrib><creatorcontrib>Zhu, Hong-can</creatorcontrib><creatorcontrib>Zhang, Guo-bin</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yan-ru</au><au>Li, Peng-wei</au><au>Suo, Jian-jun</au><au>Sun, Yan</au><au>Zhang, Bo-ai</au><au>Lu, Hong</au><au>Zhu, Hong-can</au><au>Zhang, Guo-bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Catalpol provides protective effects against cerebral ischaemia/reperfusion injury in gerbils</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2014-09</date><risdate>2014</risdate><volume>66</volume><issue>9</issue><spage>1265</spage><epage>1270</epage><pages>1265-1270</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><coden>JPPMAB</coden><abstract>Objectives
To investigate the protective effect of catalpol on cerebral ischaemia/reperfusion (CI/R) injury in gerbils and further explore the underlying mechanism.
Methods
A gerbil model of CI/R was prepared by bilateral common carotid occlusion for 10 min followed by 6 h reperfusion. Catalpol (5, 10 or 20 mg/kg per day) was injected intraperitoneally for 3 days before the carotid occlusion. Stroke index was measured during the reperfusion. The contents of endogenous neuropeptides, endothelin‐1 (ET‐1) and calcitonin gene‐related peptide in plasma were evaluated by radioimmunoassay. Superoxide dismutase (SOD) and malondialdehyde (MDA) in brain tissue homogenate were also examined.
Key findings
The results showed that catalpol significantly improved the stroke index compared with CI/R control group (P < 0.05 or P < 0.01). Catalpol significantly increased the activity of SOD at the doses of 10 and 20 mg/kg (P ≤ 0.05), decreased the brain MDA content and the plasma level of ET‐1 at the doses of 10 and 20 mg/kg (P ≤ 0.01).
Conclusions
These data suggested that the efficacy of catalpol pretreatment on CI/R injury may be attributed to reduction of free radicals and inhibition of lipid peroxidation and ET‐1 production.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24720795</pmid><doi>10.1111/jphp.12261</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of pharmacy and pharmacology, 2014-09, Vol.66 (9), p.1265-1270 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Brain - drug effects Brain - metabolism Brain Ischemia - drug therapy Brain Ischemia - metabolism Calcitonin Gene-Related Peptide - blood catalpol Cerebral Infarction - drug therapy Cerebral Infarction - metabolism cerebral ischaemia/reperfusion injury Disease Models, Animal endothelin-1 Endothelin-1 - blood Female Free radicals Free Radicals - metabolism Gerbillinae Injections, Intraperitoneal Iridoid Glucosides - pharmacology Iridoid Glucosides - therapeutic use Lipid Peroxidation - drug effects Male malondialdehyde Malondialdehyde - metabolism Medical research Neuropeptides - metabolism Oxidative Stress - drug effects Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Rehmannia - chemistry Reperfusion Injury - blood Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Rodents Stroke - prevention & control superoxide dismutase Superoxide Dismutase - metabolism |
| title | Catalpol provides protective effects against cerebral ischaemia/reperfusion injury in gerbils |
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