Primary cutaneous follicle center lymphoma with diffuse CD30 expression: A report of 4 cases of a rare variant
Background CD30 is expressed in aggressive and Epstein–Barr virus–associated forms of B-cell non-Hodgkin lymphomas, but is rarely expressed by the majority of tumor cells in primary cutaneous B-cell lymphomas (CBCLs). The expression of CD30 in CBCLs may be at risk for misinterpretation as an unequiv...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 2014-09, Vol.71 (3), p.548-554 |
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| creator | Kempf, Werner, MD Kazakov, Dmitry V., MD, PhD Rütten, Arno, MD Rupec, Rudolf A., MD, PhD Talarcik, Petr, MD Ballová, Veronika, MD Kerl, Katrin, MD Dummer, Reinhard, MD Lautenschlager, Stephan, MD Zimmermann, Dieter R., PhD Tinguely, Marianne, MD |
| description | Background CD30 is expressed in aggressive and Epstein–Barr virus–associated forms of B-cell non-Hodgkin lymphomas, but is rarely expressed by the majority of tumor cells in primary cutaneous B-cell lymphomas (CBCLs). The expression of CD30 in CBCLs may be at risk for misinterpretation as an unequivocal indicator of a highly aggressive form of the disease. Objective We report 4 cases of low malignant primary cutaneous follicle center lymphoma (PCFCL) with diffuse and strong expression of CD30 by the majority of neoplastic cells. Results The patients included 3 men and 1 woman with tumors on the scalp (3 patients) and chest wall (1 patient). The histologic examinations revealed a mixed, diffuse, and follicular growth pattern with CD20+ , bcl-6+ , and bcl-2− tumor cells. Seventy percent to 90% of the tumor cells expressed CD30. Clonal rearrangement of immunoglobulin heavy chain genes was found in 1 of 4 cases. None of the 3 cases yielded positivity for Epstein–Barr virus RNA. Limitations The study is limited by the small number of patients. Conclusions This rare variant of CD30+ PCFCL needs be distinguished from CD30+ aggressive B-cell lymphomas. CD30 in this variant of CBCLs may serve as a therapeutic target for anti-CD30 antibody–based strategies. |
| doi_str_mv | 10.1016/j.jaad.2014.03.027 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1553705659</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0190962214012614</els_id><sourcerecordid>1553705659</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-274ac564aa22134617d25e3e60a34c57c614994cdc80b5daf686567b6f4e75353</originalsourceid><addsrcrecordid>eNp9kc2K1TAYhoMoznH0BlxIlm5a859WRBiOvzCgoK5DTvqVSW2bmrSj5256Lb0yWzq6cOHq2zzvC-_zIfSUkpwSql40eWNtlTNCRU54Tpi-hw6UlDpTutD30YHQkmSlYuwCPUqpIYSUguuH6IKJgisp5AGlz9F3Np6xm0bbQ5gSrkPbetcCdtCPEHF77oab0Fn80483y1z5up4S4OMbTjD8GiKk5EP_El_hCEOIIw41FsvsbIK0zKFeZrvM0UbAtzZ624-P0YPatgme3N1L9O3d26_HD9n1p_cfj1fXmRMFHTOmhXVSCWsZo1woqismgYMilgsntVNUlKVwlSvISVa2VoWSSp9ULUBLLvkler73DjH8mCCNpvPJQdvuQw2VkmsilSxXlO2oiyGlCLUZdi-GErPJNo3ZZJtNtiHcrLLX0LO7_unUQfU38sfuCrzaAVhX3nqIJjkPvYPKR3CjqYL_f__rf-Ku9b13tv0OZ0hNmGK_-jPUJGaI-bK9e_s2FYSyVQ7_DakIqME</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1553705659</pqid></control><display><type>article</type><title>Primary cutaneous follicle center lymphoma with diffuse CD30 expression: A report of 4 cases of a rare variant</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Kempf, Werner, MD ; Kazakov, Dmitry V., MD, PhD ; Rütten, Arno, MD ; Rupec, Rudolf A., MD, PhD ; Talarcik, Petr, MD ; Ballová, Veronika, MD ; Kerl, Katrin, MD ; Dummer, Reinhard, MD ; Lautenschlager, Stephan, MD ; Zimmermann, Dieter R., PhD ; Tinguely, Marianne, MD</creator><creatorcontrib>Kempf, Werner, MD ; Kazakov, Dmitry V., MD, PhD ; Rütten, Arno, MD ; Rupec, Rudolf A., MD, PhD ; Talarcik, Petr, MD ; Ballová, Veronika, MD ; Kerl, Katrin, MD ; Dummer, Reinhard, MD ; Lautenschlager, Stephan, MD ; Zimmermann, Dieter R., PhD ; Tinguely, Marianne, MD</creatorcontrib><description>Background CD30 is expressed in aggressive and Epstein–Barr virus–associated forms of B-cell non-Hodgkin lymphomas, but is rarely expressed by the majority of tumor cells in primary cutaneous B-cell lymphomas (CBCLs). The expression of CD30 in CBCLs may be at risk for misinterpretation as an unequivocal indicator of a highly aggressive form of the disease. Objective We report 4 cases of low malignant primary cutaneous follicle center lymphoma (PCFCL) with diffuse and strong expression of CD30 by the majority of neoplastic cells. Results The patients included 3 men and 1 woman with tumors on the scalp (3 patients) and chest wall (1 patient). The histologic examinations revealed a mixed, diffuse, and follicular growth pattern with CD20+ , bcl-6+ , and bcl-2− tumor cells. Seventy percent to 90% of the tumor cells expressed CD30. Clonal rearrangement of immunoglobulin heavy chain genes was found in 1 of 4 cases. None of the 3 cases yielded positivity for Epstein–Barr virus RNA. Limitations The study is limited by the small number of patients. Conclusions This rare variant of CD30+ PCFCL needs be distinguished from CD30+ aggressive B-cell lymphomas. CD30 in this variant of CBCLs may serve as a therapeutic target for anti-CD30 antibody–based strategies.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2014.03.027</identifier><identifier>PMID: 24836545</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Basal Cell Nevus Syndrome - epidemiology ; CD30 ; Comorbidity ; cutaneous lymphoma ; Dermatology ; diffuse large B-cell lymphoma ; Female ; follicular lymphoma ; Gorlin–Goltz syndrome ; Head and Neck Neoplasms - epidemiology ; Head and Neck Neoplasms - metabolism ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - therapy ; Humans ; Immunohistochemistry ; Ki-1 Antigen - metabolism ; Lymphoma, B-Cell - epidemiology ; Lymphoma, B-Cell - metabolism ; Lymphoma, B-Cell - pathology ; Lymphoma, B-Cell - therapy ; Male ; Middle Aged ; PTCH ; Scalp ; Skin Neoplasms - epidemiology ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; Skin Neoplasms - therapy</subject><ispartof>Journal of the American Academy of Dermatology, 2014-09, Vol.71 (3), p.548-554</ispartof><rights>American Academy of Dermatology, Inc.</rights><rights>2014 American Academy of Dermatology, Inc.</rights><rights>Copyright © 2014 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-274ac564aa22134617d25e3e60a34c57c614994cdc80b5daf686567b6f4e75353</citedby><cites>FETCH-LOGICAL-c481t-274ac564aa22134617d25e3e60a34c57c614994cdc80b5daf686567b6f4e75353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0190962214012614$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24836545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kempf, Werner, MD</creatorcontrib><creatorcontrib>Kazakov, Dmitry V., MD, PhD</creatorcontrib><creatorcontrib>Rütten, Arno, MD</creatorcontrib><creatorcontrib>Rupec, Rudolf A., MD, PhD</creatorcontrib><creatorcontrib>Talarcik, Petr, MD</creatorcontrib><creatorcontrib>Ballová, Veronika, MD</creatorcontrib><creatorcontrib>Kerl, Katrin, MD</creatorcontrib><creatorcontrib>Dummer, Reinhard, MD</creatorcontrib><creatorcontrib>Lautenschlager, Stephan, MD</creatorcontrib><creatorcontrib>Zimmermann, Dieter R., PhD</creatorcontrib><creatorcontrib>Tinguely, Marianne, MD</creatorcontrib><title>Primary cutaneous follicle center lymphoma with diffuse CD30 expression: A report of 4 cases of a rare variant</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Background CD30 is expressed in aggressive and Epstein–Barr virus–associated forms of B-cell non-Hodgkin lymphomas, but is rarely expressed by the majority of tumor cells in primary cutaneous B-cell lymphomas (CBCLs). The expression of CD30 in CBCLs may be at risk for misinterpretation as an unequivocal indicator of a highly aggressive form of the disease. Objective We report 4 cases of low malignant primary cutaneous follicle center lymphoma (PCFCL) with diffuse and strong expression of CD30 by the majority of neoplastic cells. Results The patients included 3 men and 1 woman with tumors on the scalp (3 patients) and chest wall (1 patient). The histologic examinations revealed a mixed, diffuse, and follicular growth pattern with CD20+ , bcl-6+ , and bcl-2− tumor cells. Seventy percent to 90% of the tumor cells expressed CD30. Clonal rearrangement of immunoglobulin heavy chain genes was found in 1 of 4 cases. None of the 3 cases yielded positivity for Epstein–Barr virus RNA. Limitations The study is limited by the small number of patients. Conclusions This rare variant of CD30+ PCFCL needs be distinguished from CD30+ aggressive B-cell lymphomas. CD30 in this variant of CBCLs may serve as a therapeutic target for anti-CD30 antibody–based strategies.</description><subject>Adult</subject><subject>Aged</subject><subject>Basal Cell Nevus Syndrome - epidemiology</subject><subject>CD30</subject><subject>Comorbidity</subject><subject>cutaneous lymphoma</subject><subject>Dermatology</subject><subject>diffuse large B-cell lymphoma</subject><subject>Female</subject><subject>follicular lymphoma</subject><subject>Gorlin–Goltz syndrome</subject><subject>Head and Neck Neoplasms - epidemiology</subject><subject>Head and Neck Neoplasms - metabolism</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-1 Antigen - metabolism</subject><subject>Lymphoma, B-Cell - epidemiology</subject><subject>Lymphoma, B-Cell - metabolism</subject><subject>Lymphoma, B-Cell - pathology</subject><subject>Lymphoma, B-Cell - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>PTCH</subject><subject>Scalp</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - therapy</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2K1TAYhoMoznH0BlxIlm5a859WRBiOvzCgoK5DTvqVSW2bmrSj5256Lb0yWzq6cOHq2zzvC-_zIfSUkpwSql40eWNtlTNCRU54Tpi-hw6UlDpTutD30YHQkmSlYuwCPUqpIYSUguuH6IKJgisp5AGlz9F3Np6xm0bbQ5gSrkPbetcCdtCPEHF77oab0Fn80483y1z5up4S4OMbTjD8GiKk5EP_El_hCEOIIw41FsvsbIK0zKFeZrvM0UbAtzZ624-P0YPatgme3N1L9O3d26_HD9n1p_cfj1fXmRMFHTOmhXVSCWsZo1woqismgYMilgsntVNUlKVwlSvISVa2VoWSSp9ULUBLLvkler73DjH8mCCNpvPJQdvuQw2VkmsilSxXlO2oiyGlCLUZdi-GErPJNo3ZZJtNtiHcrLLX0LO7_unUQfU38sfuCrzaAVhX3nqIJjkPvYPKR3CjqYL_f__rf-Ku9b13tv0OZ0hNmGK_-jPUJGaI-bK9e_s2FYSyVQ7_DakIqME</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Kempf, Werner, MD</creator><creator>Kazakov, Dmitry V., MD, PhD</creator><creator>Rütten, Arno, MD</creator><creator>Rupec, Rudolf A., MD, PhD</creator><creator>Talarcik, Petr, MD</creator><creator>Ballová, Veronika, MD</creator><creator>Kerl, Katrin, MD</creator><creator>Dummer, Reinhard, MD</creator><creator>Lautenschlager, Stephan, MD</creator><creator>Zimmermann, Dieter R., PhD</creator><creator>Tinguely, Marianne, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Primary cutaneous follicle center lymphoma with diffuse CD30 expression: A report of 4 cases of a rare variant</title><author>Kempf, Werner, MD ; Kazakov, Dmitry V., MD, PhD ; Rütten, Arno, MD ; Rupec, Rudolf A., MD, PhD ; Talarcik, Petr, MD ; Ballová, Veronika, MD ; Kerl, Katrin, MD ; Dummer, Reinhard, MD ; Lautenschlager, Stephan, MD ; Zimmermann, Dieter R., PhD ; Tinguely, Marianne, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-274ac564aa22134617d25e3e60a34c57c614994cdc80b5daf686567b6f4e75353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Basal Cell Nevus Syndrome - epidemiology</topic><topic>CD30</topic><topic>Comorbidity</topic><topic>cutaneous lymphoma</topic><topic>Dermatology</topic><topic>diffuse large B-cell lymphoma</topic><topic>Female</topic><topic>follicular lymphoma</topic><topic>Gorlin–Goltz syndrome</topic><topic>Head and Neck Neoplasms - epidemiology</topic><topic>Head and Neck Neoplasms - metabolism</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-1 Antigen - metabolism</topic><topic>Lymphoma, B-Cell - epidemiology</topic><topic>Lymphoma, B-Cell - metabolism</topic><topic>Lymphoma, B-Cell - pathology</topic><topic>Lymphoma, B-Cell - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>PTCH</topic><topic>Scalp</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kempf, Werner, MD</creatorcontrib><creatorcontrib>Kazakov, Dmitry V., MD, PhD</creatorcontrib><creatorcontrib>Rütten, Arno, MD</creatorcontrib><creatorcontrib>Rupec, Rudolf A., MD, PhD</creatorcontrib><creatorcontrib>Talarcik, Petr, MD</creatorcontrib><creatorcontrib>Ballová, Veronika, MD</creatorcontrib><creatorcontrib>Kerl, Katrin, MD</creatorcontrib><creatorcontrib>Dummer, Reinhard, MD</creatorcontrib><creatorcontrib>Lautenschlager, Stephan, MD</creatorcontrib><creatorcontrib>Zimmermann, Dieter R., PhD</creatorcontrib><creatorcontrib>Tinguely, Marianne, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kempf, Werner, MD</au><au>Kazakov, Dmitry V., MD, PhD</au><au>Rütten, Arno, MD</au><au>Rupec, Rudolf A., MD, PhD</au><au>Talarcik, Petr, MD</au><au>Ballová, Veronika, MD</au><au>Kerl, Katrin, MD</au><au>Dummer, Reinhard, MD</au><au>Lautenschlager, Stephan, MD</au><au>Zimmermann, Dieter R., PhD</au><au>Tinguely, Marianne, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary cutaneous follicle center lymphoma with diffuse CD30 expression: A report of 4 cases of a rare variant</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>71</volume><issue>3</issue><spage>548</spage><epage>554</epage><pages>548-554</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><abstract>Background CD30 is expressed in aggressive and Epstein–Barr virus–associated forms of B-cell non-Hodgkin lymphomas, but is rarely expressed by the majority of tumor cells in primary cutaneous B-cell lymphomas (CBCLs). The expression of CD30 in CBCLs may be at risk for misinterpretation as an unequivocal indicator of a highly aggressive form of the disease. Objective We report 4 cases of low malignant primary cutaneous follicle center lymphoma (PCFCL) with diffuse and strong expression of CD30 by the majority of neoplastic cells. Results The patients included 3 men and 1 woman with tumors on the scalp (3 patients) and chest wall (1 patient). The histologic examinations revealed a mixed, diffuse, and follicular growth pattern with CD20+ , bcl-6+ , and bcl-2− tumor cells. Seventy percent to 90% of the tumor cells expressed CD30. Clonal rearrangement of immunoglobulin heavy chain genes was found in 1 of 4 cases. None of the 3 cases yielded positivity for Epstein–Barr virus RNA. Limitations The study is limited by the small number of patients. Conclusions This rare variant of CD30+ PCFCL needs be distinguished from CD30+ aggressive B-cell lymphomas. CD30 in this variant of CBCLs may serve as a therapeutic target for anti-CD30 antibody–based strategies.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24836545</pmid><doi>10.1016/j.jaad.2014.03.027</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Basal Cell Nevus Syndrome - epidemiology CD30 Comorbidity cutaneous lymphoma Dermatology diffuse large B-cell lymphoma Female follicular lymphoma Gorlin–Goltz syndrome Head and Neck Neoplasms - epidemiology Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy Humans Immunohistochemistry Ki-1 Antigen - metabolism Lymphoma, B-Cell - epidemiology Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - pathology Lymphoma, B-Cell - therapy Male Middle Aged PTCH Scalp Skin Neoplasms - epidemiology Skin Neoplasms - metabolism Skin Neoplasms - pathology Skin Neoplasms - therapy |
| title | Primary cutaneous follicle center lymphoma with diffuse CD30 expression: A report of 4 cases of a rare variant |
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