Reference values for placental growth factor (PlGF) concentration and uterine artery doppler pulsatility index (PI) at 11-13(+6) weeks of gestation in the Polish population
The aim of the study was to determine placental growth factor (PIGF) concentration and uterine artery (UtA) Doppler pulsatility index (PI) at 11-13(+6) weeks of gestation in the Polish population. A prospective study was performed in pregnant women who underwent routine ultrasound scan at 11-13(+6)...
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| Veröffentlicht in: | Ginekologia polska 2014-07, Vol.85 (7), p.488-493 |
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| creator | Kosiński, Przemysław Samaha, Robert Brawura Biskupski Bomba-Opoń, Dorota A Kozłowski, Szymon Lipa, Michał Kaczyński, Bartosz Zbucka-Kretowska, Monika Lawicki, Sławomir Szmitkowski, Maciej Wolczyński, Sławomir Wielgoś, Mirosław |
| description | The aim of the study was to determine placental growth factor (PIGF) concentration and uterine artery (UtA) Doppler pulsatility index (PI) at 11-13(+6) weeks of gestation in the Polish population.
A prospective study was performed in pregnant women who underwent routine ultrasound scan at 11-13(+6) weeks of gestation. All participants completed a questionnaire about their medical history demographics and current pregnancy. Mean arterial pressure (MAP) was calculated. Gestational age was confirmed by CRL and mean UtA PI was calculated. Blood samples were taken to measure beta HCG, PAPP-A and P/GF concentrations.
Out of the 577 analyzed participants, 60 (10.4%) were found to have abnormal placentation disorders (20 -hypertensive disorders and 40-IUGR). The patients were subdivided into two groups, depending on pregnancy outcome: unaffected (n = 517) and affected (n = 60). The study did not confirm the anticipated correlation between maternal BMI and PIGF, but the concentration of PIGF was significantly increased in smokers. UtA PI values were not statistically significantly different depending on maternal age, BMI, method of conception, smoking or parity The study confirms that both, UtA PI and PIGF concentrations are CRL-dependent. Median MoM values for PIGF and UtA PI were obtained for each set of CRL measurements. Median PIGF MoM was decreased in pregnancies complicated by hypertensive disorders and IUGR as compared to the unaffected group.
The established reference ranges for UtA PI and PIGF at 11-13(+6) weeks of gestation may be of clinical value in predicting placenta-associated diseases in early stages of pregnancy in the Polish population. |
| doi_str_mv | 10.17772/gp/1758 |
| format | Article |
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A prospective study was performed in pregnant women who underwent routine ultrasound scan at 11-13(+6) weeks of gestation. All participants completed a questionnaire about their medical history demographics and current pregnancy. Mean arterial pressure (MAP) was calculated. Gestational age was confirmed by CRL and mean UtA PI was calculated. Blood samples were taken to measure beta HCG, PAPP-A and P/GF concentrations.
Out of the 577 analyzed participants, 60 (10.4%) were found to have abnormal placentation disorders (20 -hypertensive disorders and 40-IUGR). The patients were subdivided into two groups, depending on pregnancy outcome: unaffected (n = 517) and affected (n = 60). The study did not confirm the anticipated correlation between maternal BMI and PIGF, but the concentration of PIGF was significantly increased in smokers. UtA PI values were not statistically significantly different depending on maternal age, BMI, method of conception, smoking or parity The study confirms that both, UtA PI and PIGF concentrations are CRL-dependent. Median MoM values for PIGF and UtA PI were obtained for each set of CRL measurements. Median PIGF MoM was decreased in pregnancies complicated by hypertensive disorders and IUGR as compared to the unaffected group.
The established reference ranges for UtA PI and PIGF at 11-13(+6) weeks of gestation may be of clinical value in predicting placenta-associated diseases in early stages of pregnancy in the Polish population.</description><identifier>ISSN: 0017-0011</identifier><identifier>DOI: 10.17772/gp/1758</identifier><identifier>PMID: 25118498</identifier><language>eng</language><publisher>Poland</publisher><subject>Adult ; Arterial Pressure - physiology ; Female ; Gestational Age ; Humans ; Male ; Maternal Age ; Placenta Growth Factor ; Poland ; Pre-Eclampsia - blood ; Pre-Eclampsia - diagnosis ; Pre-Eclampsia - diagnostic imaging ; Predictive Value of Tests ; Pregnancy ; Pregnancy Proteins - blood ; Pregnancy Trimester, First - blood ; Pregnancy Trimester, First - physiology ; Prospective Studies ; Pulsatile Flow ; Reference Values ; Ultrasonography, Prenatal ; Uterine Artery - diagnostic imaging</subject><ispartof>Ginekologia polska, 2014-07, Vol.85 (7), p.488-493</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25118498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kosiński, Przemysław</creatorcontrib><creatorcontrib>Samaha, Robert Brawura Biskupski</creatorcontrib><creatorcontrib>Bomba-Opoń, Dorota A</creatorcontrib><creatorcontrib>Kozłowski, Szymon</creatorcontrib><creatorcontrib>Lipa, Michał</creatorcontrib><creatorcontrib>Kaczyński, Bartosz</creatorcontrib><creatorcontrib>Zbucka-Kretowska, Monika</creatorcontrib><creatorcontrib>Lawicki, Sławomir</creatorcontrib><creatorcontrib>Szmitkowski, Maciej</creatorcontrib><creatorcontrib>Wolczyński, Sławomir</creatorcontrib><creatorcontrib>Wielgoś, Mirosław</creatorcontrib><title>Reference values for placental growth factor (PlGF) concentration and uterine artery doppler pulsatility index (PI) at 11-13(+6) weeks of gestation in the Polish population</title><title>Ginekologia polska</title><addtitle>Ginekol Pol</addtitle><description>The aim of the study was to determine placental growth factor (PIGF) concentration and uterine artery (UtA) Doppler pulsatility index (PI) at 11-13(+6) weeks of gestation in the Polish population.
A prospective study was performed in pregnant women who underwent routine ultrasound scan at 11-13(+6) weeks of gestation. All participants completed a questionnaire about their medical history demographics and current pregnancy. Mean arterial pressure (MAP) was calculated. Gestational age was confirmed by CRL and mean UtA PI was calculated. Blood samples were taken to measure beta HCG, PAPP-A and P/GF concentrations.
Out of the 577 analyzed participants, 60 (10.4%) were found to have abnormal placentation disorders (20 -hypertensive disorders and 40-IUGR). The patients were subdivided into two groups, depending on pregnancy outcome: unaffected (n = 517) and affected (n = 60). The study did not confirm the anticipated correlation between maternal BMI and PIGF, but the concentration of PIGF was significantly increased in smokers. UtA PI values were not statistically significantly different depending on maternal age, BMI, method of conception, smoking or parity The study confirms that both, UtA PI and PIGF concentrations are CRL-dependent. Median MoM values for PIGF and UtA PI were obtained for each set of CRL measurements. Median PIGF MoM was decreased in pregnancies complicated by hypertensive disorders and IUGR as compared to the unaffected group.
The established reference ranges for UtA PI and PIGF at 11-13(+6) weeks of gestation may be of clinical value in predicting placenta-associated diseases in early stages of pregnancy in the Polish population.</description><subject>Adult</subject><subject>Arterial Pressure - physiology</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Male</subject><subject>Maternal Age</subject><subject>Placenta Growth Factor</subject><subject>Poland</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pre-Eclampsia - diagnostic imaging</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Pregnancy Proteins - blood</subject><subject>Pregnancy Trimester, First - blood</subject><subject>Pregnancy Trimester, First - physiology</subject><subject>Prospective Studies</subject><subject>Pulsatile Flow</subject><subject>Reference Values</subject><subject>Ultrasonography, Prenatal</subject><subject>Uterine Artery - diagnostic imaging</subject><issn>0017-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1u2zAQhHloUBtJgD5BsUcbgRr-SKJ0DILYNWCgQdGeDVJa2mpoUiGpuH6nPmTZJN3D7mBn8B2GkE-MfmFSSn67H2-ZrJoPZE4pk0VebEauY_xF89Rc8rb9SGa8Yqwp22ZO_nxHgwFdh_Ci7IQRjA8wWtWhS8rCPvhTOoBRXcr_xaNdr5bQeffPDioN3oFyPUwJw-AQVMjiDL0fR4uZM9mYQ3ZIZxhcj78zYbMElYCxgonFTb2EE-JTBG9gjzG9EQcH6YDw6O0QDzD6jHk1rsiFUTbi9fu9JD9XDz_uvxbbb-vN_d22GDljqRBco6k1o1VjTN0zRNXTskSuakOVqPoaWddoXVa97LSQoqqF5k2NWre8bKm4JIs37hj8c-4k7Y5D7NBa5dBPcceqSkhaNqLM0c_v0Ukfsd-NYTiqcN79b1j8BQ-KfMg</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Kosiński, Przemysław</creator><creator>Samaha, Robert Brawura Biskupski</creator><creator>Bomba-Opoń, Dorota A</creator><creator>Kozłowski, Szymon</creator><creator>Lipa, Michał</creator><creator>Kaczyński, Bartosz</creator><creator>Zbucka-Kretowska, Monika</creator><creator>Lawicki, Sławomir</creator><creator>Szmitkowski, Maciej</creator><creator>Wolczyński, Sławomir</creator><creator>Wielgoś, Mirosław</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201407</creationdate><title>Reference values for placental growth factor (PlGF) concentration and uterine artery doppler pulsatility index (PI) at 11-13(+6) weeks of gestation in the Polish population</title><author>Kosiński, Przemysław ; Samaha, Robert Brawura Biskupski ; Bomba-Opoń, Dorota A ; Kozłowski, Szymon ; Lipa, Michał ; Kaczyński, Bartosz ; Zbucka-Kretowska, Monika ; Lawicki, Sławomir ; Szmitkowski, Maciej ; Wolczyński, Sławomir ; Wielgoś, Mirosław</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-32bef6b1058ff6d1eead044e2a6f0a35d6e1c8bb45d7cb373563b286ebb924903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Arterial Pressure - physiology</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Male</topic><topic>Maternal Age</topic><topic>Placenta Growth Factor</topic><topic>Poland</topic><topic>Pre-Eclampsia - blood</topic><topic>Pre-Eclampsia - diagnosis</topic><topic>Pre-Eclampsia - diagnostic imaging</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Pregnancy Proteins - blood</topic><topic>Pregnancy Trimester, First - blood</topic><topic>Pregnancy Trimester, First - physiology</topic><topic>Prospective Studies</topic><topic>Pulsatile Flow</topic><topic>Reference Values</topic><topic>Ultrasonography, Prenatal</topic><topic>Uterine Artery - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kosiński, Przemysław</creatorcontrib><creatorcontrib>Samaha, Robert Brawura Biskupski</creatorcontrib><creatorcontrib>Bomba-Opoń, Dorota A</creatorcontrib><creatorcontrib>Kozłowski, Szymon</creatorcontrib><creatorcontrib>Lipa, Michał</creatorcontrib><creatorcontrib>Kaczyński, Bartosz</creatorcontrib><creatorcontrib>Zbucka-Kretowska, Monika</creatorcontrib><creatorcontrib>Lawicki, Sławomir</creatorcontrib><creatorcontrib>Szmitkowski, Maciej</creatorcontrib><creatorcontrib>Wolczyński, Sławomir</creatorcontrib><creatorcontrib>Wielgoś, Mirosław</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Ginekologia polska</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kosiński, Przemysław</au><au>Samaha, Robert Brawura Biskupski</au><au>Bomba-Opoń, Dorota A</au><au>Kozłowski, Szymon</au><au>Lipa, Michał</au><au>Kaczyński, Bartosz</au><au>Zbucka-Kretowska, Monika</au><au>Lawicki, Sławomir</au><au>Szmitkowski, Maciej</au><au>Wolczyński, Sławomir</au><au>Wielgoś, Mirosław</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reference values for placental growth factor (PlGF) concentration and uterine artery doppler pulsatility index (PI) at 11-13(+6) weeks of gestation in the Polish population</atitle><jtitle>Ginekologia polska</jtitle><addtitle>Ginekol Pol</addtitle><date>2014-07</date><risdate>2014</risdate><volume>85</volume><issue>7</issue><spage>488</spage><epage>493</epage><pages>488-493</pages><issn>0017-0011</issn><abstract>The aim of the study was to determine placental growth factor (PIGF) concentration and uterine artery (UtA) Doppler pulsatility index (PI) at 11-13(+6) weeks of gestation in the Polish population.
A prospective study was performed in pregnant women who underwent routine ultrasound scan at 11-13(+6) weeks of gestation. All participants completed a questionnaire about their medical history demographics and current pregnancy. Mean arterial pressure (MAP) was calculated. Gestational age was confirmed by CRL and mean UtA PI was calculated. Blood samples were taken to measure beta HCG, PAPP-A and P/GF concentrations.
Out of the 577 analyzed participants, 60 (10.4%) were found to have abnormal placentation disorders (20 -hypertensive disorders and 40-IUGR). The patients were subdivided into two groups, depending on pregnancy outcome: unaffected (n = 517) and affected (n = 60). The study did not confirm the anticipated correlation between maternal BMI and PIGF, but the concentration of PIGF was significantly increased in smokers. UtA PI values were not statistically significantly different depending on maternal age, BMI, method of conception, smoking or parity The study confirms that both, UtA PI and PIGF concentrations are CRL-dependent. Median MoM values for PIGF and UtA PI were obtained for each set of CRL measurements. Median PIGF MoM was decreased in pregnancies complicated by hypertensive disorders and IUGR as compared to the unaffected group.
The established reference ranges for UtA PI and PIGF at 11-13(+6) weeks of gestation may be of clinical value in predicting placenta-associated diseases in early stages of pregnancy in the Polish population.</abstract><cop>Poland</cop><pmid>25118498</pmid><doi>10.17772/gp/1758</doi><tpages>6</tpages></addata></record> |
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| ispartof | Ginekologia polska, 2014-07, Vol.85 (7), p.488-493 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Arterial Pressure - physiology Female Gestational Age Humans Male Maternal Age Placenta Growth Factor Poland Pre-Eclampsia - blood Pre-Eclampsia - diagnosis Pre-Eclampsia - diagnostic imaging Predictive Value of Tests Pregnancy Pregnancy Proteins - blood Pregnancy Trimester, First - blood Pregnancy Trimester, First - physiology Prospective Studies Pulsatile Flow Reference Values Ultrasonography, Prenatal Uterine Artery - diagnostic imaging |
| title | Reference values for placental growth factor (PlGF) concentration and uterine artery doppler pulsatility index (PI) at 11-13(+6) weeks of gestation in the Polish population |
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