Systematic review of carcinoma arising in pharyngeal diverticula: A 112-year analysis
Background Carcinoma is a rare complication of pharyngeal diverticula. There is a paucity of information about its incidence, presentation, management, and treatment outcomes. A systematic review and analysis of all reported cases has been carried out. Methods A comprehensive literature search for p...
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| Veröffentlicht in: | Head & neck 2014-09, Vol.36 (9), p.1368-1375 |
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| creator | Khan, Afroze S. Dwivedi, Raghav C. Sheikh, Zishan Khan, Shahnawaz Dwivedi, Ravi C. Kanwar, Namita Agrawal, Nishant UI Hassan, Mohammed Sultan Kazi, Rehan Rhys-Evans, Peter |
| description | Background
Carcinoma is a rare complication of pharyngeal diverticula. There is a paucity of information about its incidence, presentation, management, and treatment outcomes. A systematic review and analysis of all reported cases has been carried out.
Methods
A comprehensive literature search for pharyngeal diverticula carcinoma was performed from 1896 to 2008. Descriptive analyses were carried out by analyzing the absolute and relative frequencies. Comparison of groups was illustrated with Kaplan–Meier curves and tested statistically using the log‐rank test. A cohort of 56 patients with benign pharyngeal diverticula was selected for comparison with the accumulated cohort of pharyngeal diverticula carcinoma, and a Fisher's exact test was carried out on the extracted clinical characteristics of this cohort to evaluate for differences between benign and malignant pharyngeal diverticula.
Results
Forty‐three articles reporting 60 cases satisfied the inclusion criteria. The mean age at presentation was 68.8 years (SD = 9.8 years). Five‐year cancer‐specific survival (CSS) rates for patients who underwent excision alone, excision + postoperative radiotherapy (PORT), and radiotherapy alone were 0.74 versus 0.63 versus 0.0, respectively (p = .39). Five‐year CSS rates of patients |
| doi_str_mv | 10.1002/hed.23491 |
| format | Article |
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Carcinoma is a rare complication of pharyngeal diverticula. There is a paucity of information about its incidence, presentation, management, and treatment outcomes. A systematic review and analysis of all reported cases has been carried out.
Methods
A comprehensive literature search for pharyngeal diverticula carcinoma was performed from 1896 to 2008. Descriptive analyses were carried out by analyzing the absolute and relative frequencies. Comparison of groups was illustrated with Kaplan–Meier curves and tested statistically using the log‐rank test. A cohort of 56 patients with benign pharyngeal diverticula was selected for comparison with the accumulated cohort of pharyngeal diverticula carcinoma, and a Fisher's exact test was carried out on the extracted clinical characteristics of this cohort to evaluate for differences between benign and malignant pharyngeal diverticula.
Results
Forty‐three articles reporting 60 cases satisfied the inclusion criteria. The mean age at presentation was 68.8 years (SD = 9.8 years). Five‐year cancer‐specific survival (CSS) rates for patients who underwent excision alone, excision + postoperative radiotherapy (PORT), and radiotherapy alone were 0.74 versus 0.63 versus 0.0, respectively (p = .39). Five‐year CSS rates of patients <65 versus ≥65 years were 0.43 versus 0.78, respectively (p = .046).
Conclusion
Irregular symptoms in benign diverticula should raise suspicion of malignancy. Management consists of surgical excision ± PORT. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1368–1375, 2014</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.23491</identifier><identifier>PMID: 23996210</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>carcinoma ; Carcinoma - diagnosis ; Carcinoma - epidemiology ; Carcinoma - therapy ; head and neck cancers ; Humans ; Medical research ; pharyngeal diverticula ; Pharyngeal Neoplasms - diagnosis ; Pharyngeal Neoplasms - epidemiology ; Pharyngeal Neoplasms - therapy ; Radiation therapy ; Zenker Diverticulum ; Zenker's diverticulum</subject><ispartof>Head & neck, 2014-09, Vol.36 (9), p.1368-1375</ispartof><rights>Copyright © 2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4271-10d751dfb6d7f80103b179897e0bd54d773936844fe9462a5eb909682991a4473</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.23491$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.23491$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23996210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Afroze S.</creatorcontrib><creatorcontrib>Dwivedi, Raghav C.</creatorcontrib><creatorcontrib>Sheikh, Zishan</creatorcontrib><creatorcontrib>Khan, Shahnawaz</creatorcontrib><creatorcontrib>Dwivedi, Ravi C.</creatorcontrib><creatorcontrib>Kanwar, Namita</creatorcontrib><creatorcontrib>Agrawal, Nishant</creatorcontrib><creatorcontrib>UI Hassan, Mohammed Sultan</creatorcontrib><creatorcontrib>Kazi, Rehan</creatorcontrib><creatorcontrib>Rhys-Evans, Peter</creatorcontrib><title>Systematic review of carcinoma arising in pharyngeal diverticula: A 112-year analysis</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Carcinoma is a rare complication of pharyngeal diverticula. There is a paucity of information about its incidence, presentation, management, and treatment outcomes. A systematic review and analysis of all reported cases has been carried out.
Methods
A comprehensive literature search for pharyngeal diverticula carcinoma was performed from 1896 to 2008. Descriptive analyses were carried out by analyzing the absolute and relative frequencies. Comparison of groups was illustrated with Kaplan–Meier curves and tested statistically using the log‐rank test. A cohort of 56 patients with benign pharyngeal diverticula was selected for comparison with the accumulated cohort of pharyngeal diverticula carcinoma, and a Fisher's exact test was carried out on the extracted clinical characteristics of this cohort to evaluate for differences between benign and malignant pharyngeal diverticula.
Results
Forty‐three articles reporting 60 cases satisfied the inclusion criteria. The mean age at presentation was 68.8 years (SD = 9.8 years). Five‐year cancer‐specific survival (CSS) rates for patients who underwent excision alone, excision + postoperative radiotherapy (PORT), and radiotherapy alone were 0.74 versus 0.63 versus 0.0, respectively (p = .39). Five‐year CSS rates of patients <65 versus ≥65 years were 0.43 versus 0.78, respectively (p = .046).
Conclusion
Irregular symptoms in benign diverticula should raise suspicion of malignancy. Management consists of surgical excision ± PORT. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1368–1375, 2014</description><subject>carcinoma</subject><subject>Carcinoma - diagnosis</subject><subject>Carcinoma - epidemiology</subject><subject>Carcinoma - therapy</subject><subject>head and neck cancers</subject><subject>Humans</subject><subject>Medical research</subject><subject>pharyngeal diverticula</subject><subject>Pharyngeal Neoplasms - diagnosis</subject><subject>Pharyngeal Neoplasms - epidemiology</subject><subject>Pharyngeal Neoplasms - therapy</subject><subject>Radiation therapy</subject><subject>Zenker Diverticulum</subject><subject>Zenker's diverticulum</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUlPwzAQhS0EYikc-APIEhcuoR7biWNuUFaxHShC4mI5iQOGLMVuWvLvMS1w4DRPmu-NZuYhtAvkEAihw1dTHFLGJaygTSBSRIRxsfqtOYsYEXwDbXn_RghhCafraIMyKRMKZBM9PvR-amo9tTl2ZmbNHLclzrXLbdPWGmtnvW1esG3w5FW7vnkxusKFnRkXLF2lj_AxBqBRb7TDutFV763fRmulrrzZ-akD9Hh-Nh5dRjf3F1ej45so51RABKQQMRRllhSiTAkQloGQqRSGZEXMCyGYZEnKeWkkT6iOTSaJTFIqJWjOBRugg-XciWs_OuOnqrY-N1WlG9N2XkEcM0aBUhrQ_X_oW9u5sO-CokLKNEkDtfdDdVltCjVxtg5Xq9-HBWC4BOa2Mv1fH4j6TkKFJNQiCXV5droQwREtHTY8-vPPod27SgQTsXq6u1Ano_Hz7ek1qDH7AqZRhxI</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Khan, Afroze S.</creator><creator>Dwivedi, Raghav C.</creator><creator>Sheikh, Zishan</creator><creator>Khan, Shahnawaz</creator><creator>Dwivedi, Ravi C.</creator><creator>Kanwar, Namita</creator><creator>Agrawal, Nishant</creator><creator>UI Hassan, Mohammed Sultan</creator><creator>Kazi, Rehan</creator><creator>Rhys-Evans, Peter</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201409</creationdate><title>Systematic review of carcinoma arising in pharyngeal diverticula: A 112-year analysis</title><author>Khan, Afroze S. ; Dwivedi, Raghav C. ; Sheikh, Zishan ; Khan, Shahnawaz ; Dwivedi, Ravi C. ; Kanwar, Namita ; Agrawal, Nishant ; UI Hassan, Mohammed Sultan ; Kazi, Rehan ; Rhys-Evans, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4271-10d751dfb6d7f80103b179897e0bd54d773936844fe9462a5eb909682991a4473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>carcinoma</topic><topic>Carcinoma - diagnosis</topic><topic>Carcinoma - epidemiology</topic><topic>Carcinoma - therapy</topic><topic>head and neck cancers</topic><topic>Humans</topic><topic>Medical research</topic><topic>pharyngeal diverticula</topic><topic>Pharyngeal Neoplasms - diagnosis</topic><topic>Pharyngeal Neoplasms - epidemiology</topic><topic>Pharyngeal Neoplasms - therapy</topic><topic>Radiation therapy</topic><topic>Zenker Diverticulum</topic><topic>Zenker's diverticulum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Afroze S.</creatorcontrib><creatorcontrib>Dwivedi, Raghav C.</creatorcontrib><creatorcontrib>Sheikh, Zishan</creatorcontrib><creatorcontrib>Khan, Shahnawaz</creatorcontrib><creatorcontrib>Dwivedi, Ravi C.</creatorcontrib><creatorcontrib>Kanwar, Namita</creatorcontrib><creatorcontrib>Agrawal, Nishant</creatorcontrib><creatorcontrib>UI Hassan, Mohammed Sultan</creatorcontrib><creatorcontrib>Kazi, Rehan</creatorcontrib><creatorcontrib>Rhys-Evans, Peter</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Afroze S.</au><au>Dwivedi, Raghav C.</au><au>Sheikh, Zishan</au><au>Khan, Shahnawaz</au><au>Dwivedi, Ravi C.</au><au>Kanwar, Namita</au><au>Agrawal, Nishant</au><au>UI Hassan, Mohammed Sultan</au><au>Kazi, Rehan</au><au>Rhys-Evans, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systematic review of carcinoma arising in pharyngeal diverticula: A 112-year analysis</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2014-09</date><risdate>2014</risdate><volume>36</volume><issue>9</issue><spage>1368</spage><epage>1375</epage><pages>1368-1375</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
Carcinoma is a rare complication of pharyngeal diverticula. There is a paucity of information about its incidence, presentation, management, and treatment outcomes. A systematic review and analysis of all reported cases has been carried out.
Methods
A comprehensive literature search for pharyngeal diverticula carcinoma was performed from 1896 to 2008. Descriptive analyses were carried out by analyzing the absolute and relative frequencies. Comparison of groups was illustrated with Kaplan–Meier curves and tested statistically using the log‐rank test. A cohort of 56 patients with benign pharyngeal diverticula was selected for comparison with the accumulated cohort of pharyngeal diverticula carcinoma, and a Fisher's exact test was carried out on the extracted clinical characteristics of this cohort to evaluate for differences between benign and malignant pharyngeal diverticula.
Results
Forty‐three articles reporting 60 cases satisfied the inclusion criteria. The mean age at presentation was 68.8 years (SD = 9.8 years). Five‐year cancer‐specific survival (CSS) rates for patients who underwent excision alone, excision + postoperative radiotherapy (PORT), and radiotherapy alone were 0.74 versus 0.63 versus 0.0, respectively (p = .39). Five‐year CSS rates of patients <65 versus ≥65 years were 0.43 versus 0.78, respectively (p = .046).
Conclusion
Irregular symptoms in benign diverticula should raise suspicion of malignancy. Management consists of surgical excision ± PORT. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1368–1375, 2014</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23996210</pmid><doi>10.1002/hed.23491</doi><tpages>8</tpages></addata></record> |
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| subjects | carcinoma Carcinoma - diagnosis Carcinoma - epidemiology Carcinoma - therapy head and neck cancers Humans Medical research pharyngeal diverticula Pharyngeal Neoplasms - diagnosis Pharyngeal Neoplasms - epidemiology Pharyngeal Neoplasms - therapy Radiation therapy Zenker Diverticulum Zenker's diverticulum |
| title | Systematic review of carcinoma arising in pharyngeal diverticula: A 112-year analysis |
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