Linezolid Dampens Neutrophil-Mediated Inflammation in Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia and Protects the Lung of Associated Damages

Background. Linezolid is considered as a therapeutic alternative to the use of glycopeptides for the treatment of pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA). Clinical studies reported a potent survival advantage conferred by the oxazolidinone and called into question the...

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Veröffentlicht in:	The Journal of infectious diseases 2014-09, Vol.210 (5), p.814-823
Hauptverfasser:	Jacqueline, Cédric, Broquet, Alexis, Roquilly, Antoine, Davieau, Marion, Caillon, Jocelyne, Altare, Frédéric, Potel, Gilles, Asehnoune, Karim
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - administration & dosage Animals Anti-Bacterial Agents - administration & dosage Antibacterials Antigens, Ly - analysis Bacteria Bacterial Load Bacteriology Biological and medical sciences Cytokines Cytokines - analysis Disease Models, Animal Endothelial Cells - physiology Fundamental and applied biological sciences. Psychology Immunologic Factors - administration & dosage Infections Infectious diseases Injections, Subcutaneous Linezolid Lung - microbiology Lung - pathology Lungs Medical sciences Methicillin resistant staphylococcus aureus Methicillin-Resistant Staphylococcus aureus - growth & development Mice Microbiology Miscellaneous Neutrophils Neutrophils - drug effects Neutrophils - immunology Oxazolidinones - administration & dosage PATHOGENESIS AND HOST RESPONSE Peroxidase - analysis Pneumonia Pneumonia, Staphylococcal - immunology Pneumonia, Staphylococcal - microbiology Pneumonia, Staphylococcal - pathology Staphylococcal pneumonia Vancomycin - administration & dosage
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