Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation
Summary Invasive opportunistic fungal diseases (IFDs) are important causes of morbidity and mortality in paediatric patients with cancer and those who have had an allogeneic haemopoietic stem-cell transplantation (HSCT). Apart from differences in underlying disorders and comorbidities relative to th...
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| Veröffentlicht in: | The lancet oncology 2014-07, Vol.15 (8), p.e327-e340 |
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| creator | Groll, Andreas H, Prof Castagnola, Elio, Prof Cesaro, Simone, Prof Dalle, Jean-Hugues, MD Engelhard, Dan, Prof Hope, William, Prof Roilides, Emmanuel, Prof Styczynski, Jan, Prof Warris, Adilia, MD Lehrnbecher, Thomas, Prof |
| description | Summary Invasive opportunistic fungal diseases (IFDs) are important causes of morbidity and mortality in paediatric patients with cancer and those who have had an allogeneic haemopoietic stem-cell transplantation (HSCT). Apart from differences in underlying disorders and comorbidities relative to those of adults, IFDs in infants, children, and adolescents are unique with respect to their epidemiology, the usefulness of diagnostic methods, the pharmacology and dosing of antifungal agents, and the absence of interventional phase 3 clinical trials for guidance of evidence-based decisions. To better define the state of knowledge on IFDs in paediatric patients with cancer and allogeneic HSCT and to improve IFD diagnosis, prevention, and management, the Fourth European Conference on Infections in Leukaemia (ECIL-4) in 2011 convened a group that reviewed the scientific literature on IFDs and graded the available quality of evidence according to the Infectious Diseases Society of America grading system. The final considerations and recommendations of the group are summarised in this manuscript. |
| doi_str_mv | 10.1016/S1470-2045(14)70017-8 |
| format | Article |
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Apart from differences in underlying disorders and comorbidities relative to those of adults, IFDs in infants, children, and adolescents are unique with respect to their epidemiology, the usefulness of diagnostic methods, the pharmacology and dosing of antifungal agents, and the absence of interventional phase 3 clinical trials for guidance of evidence-based decisions. To better define the state of knowledge on IFDs in paediatric patients with cancer and allogeneic HSCT and to improve IFD diagnosis, prevention, and management, the Fourth European Conference on Infections in Leukaemia (ECIL-4) in 2011 convened a group that reviewed the scientific literature on IFDs and graded the available quality of evidence according to the Infectious Diseases Society of America grading system. The final considerations and recommendations of the group are summarised in this manuscript.</description><identifier>ISSN: 1470-2045</identifier><identifier>EISSN: 1474-5488</identifier><identifier>DOI: 10.1016/S1470-2045(14)70017-8</identifier><identifier>PMID: 24988936</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Antifungal Agents - therapeutic use ; Cancer ; Child ; Child, Preschool ; Disease prevention ; Drug dosages ; Epidemiology ; Hematology, Oncology and Palliative Medicine ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Infant ; Leukemia - complications ; Mortality ; Mycoses - diagnosis ; Mycoses - drug therapy ; Mycoses - epidemiology ; Mycoses - etiology ; Mycoses - prevention & control ; Opportunistic Infections - diagnosis ; Opportunistic Infections - drug therapy ; Opportunistic Infections - epidemiology ; Opportunistic Infections - etiology ; Opportunistic Infections - prevention & control ; Regulatory approval ; Risk factors ; Transplantation, Homologous</subject><ispartof>The lancet oncology, 2014-07, Vol.15 (8), p.e327-e340</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Jul 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-b9e849e51ad789bdd0f0d672baf7d9d7dcbe6ac7cfc45248f34f3cc9aceb92c03</citedby><cites>FETCH-LOGICAL-c448t-b9e849e51ad789bdd0f0d672baf7d9d7dcbe6ac7cfc45248f34f3cc9aceb92c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1470204514700178$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24988936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Groll, Andreas H, Prof</creatorcontrib><creatorcontrib>Castagnola, Elio, Prof</creatorcontrib><creatorcontrib>Cesaro, Simone, Prof</creatorcontrib><creatorcontrib>Dalle, Jean-Hugues, MD</creatorcontrib><creatorcontrib>Engelhard, Dan, Prof</creatorcontrib><creatorcontrib>Hope, William, Prof</creatorcontrib><creatorcontrib>Roilides, Emmanuel, Prof</creatorcontrib><creatorcontrib>Styczynski, Jan, Prof</creatorcontrib><creatorcontrib>Warris, Adilia, MD</creatorcontrib><creatorcontrib>Lehrnbecher, Thomas, Prof</creatorcontrib><creatorcontrib>the Infectious Diseases Group of the European Organisation for Research and Treatment of Cancer (EORTC-IDG)</creatorcontrib><creatorcontrib>a joint venture of the Infectious Diseases Working Party of the European Group for Blood Marrow Transplantation (EBMT-IDWP)</creatorcontrib><creatorcontrib>the European Leukaemia Net (ELN)</creatorcontrib><creatorcontrib>on behalf of the Fourth European Conference on Infections in Leukaemia</creatorcontrib><creatorcontrib>the International Immunocompromised Host Society (ICHS)</creatorcontrib><creatorcontrib>Infectious Diseases Working Party of the European Group for Blood Marrow Transplantation (EBMT-IDWP)</creatorcontrib><creatorcontrib>International Immunocompromised Host Society (ICHS)</creatorcontrib><creatorcontrib>Infectious Diseases Group of the European Organisation for Research and Treatment of Cancer (EORTC-IDG)</creatorcontrib><creatorcontrib>Fourth European Conference on Infections in Leukaemia</creatorcontrib><creatorcontrib>European Leukaemia Net (ELN)</creatorcontrib><title>Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation</title><title>The lancet oncology</title><addtitle>Lancet Oncol</addtitle><description>Summary Invasive opportunistic fungal diseases (IFDs) are important causes of morbidity and mortality in paediatric patients with cancer and those who have had an allogeneic haemopoietic stem-cell transplantation (HSCT). Apart from differences in underlying disorders and comorbidities relative to those of adults, IFDs in infants, children, and adolescents are unique with respect to their epidemiology, the usefulness of diagnostic methods, the pharmacology and dosing of antifungal agents, and the absence of interventional phase 3 clinical trials for guidance of evidence-based decisions. To better define the state of knowledge on IFDs in paediatric patients with cancer and allogeneic HSCT and to improve IFD diagnosis, prevention, and management, the Fourth European Conference on Infections in Leukaemia (ECIL-4) in 2011 convened a group that reviewed the scientific literature on IFDs and graded the available quality of evidence according to the Infectious Diseases Society of America grading system. The final considerations and recommendations of the group are summarised in this manuscript.</description><subject>Adolescent</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Cancer</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disease prevention</subject><subject>Drug dosages</subject><subject>Epidemiology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Infant</subject><subject>Leukemia - complications</subject><subject>Mortality</subject><subject>Mycoses - diagnosis</subject><subject>Mycoses - drug therapy</subject><subject>Mycoses - epidemiology</subject><subject>Mycoses - etiology</subject><subject>Mycoses - prevention & control</subject><subject>Opportunistic Infections - diagnosis</subject><subject>Opportunistic Infections - drug therapy</subject><subject>Opportunistic Infections - epidemiology</subject><subject>Opportunistic Infections - etiology</subject><subject>Opportunistic Infections - prevention & control</subject><subject>Regulatory approval</subject><subject>Risk factors</subject><subject>Transplantation, Homologous</subject><issn>1470-2045</issn><issn>1474-5488</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkt1u1DAQhSMEoj_wCCBL3GylBuzE2SRcgNBqCyutxAVwbU3sydZtYgc7WdQn7msw2S0g9YYr_-ibM8c-kySvBH8ruFi--yZkydOMy2Ih5EXJuSjT6klyStcyLWRVPT3sj8hJchbjzcwIXjxPTjJZV1WdL0-T-ys_hfGarafgBwTHVt61GNBpZN6xDR30aL2LzDq2xekWsLfAFuvVZpvKi_dsN1mDnXUYWesDMxZ2zkcbL9kQcI9uLr5k4AwbA8LY0w3zLantIdo9snZyO-ioLiJEPLQZAElmDFbTdrRUEdkvSyY1kK3AqA10nd-hQ0KuyZEfvMWRDnHEPtXYddQNXBw6cCPMFl4kz1roIr58WM-TH1fr76sv6fbr583q0zbVUlZj2tRYyRoLAaas6sYY3nKzLLMG2tLUpjS6wSXoUrdaFpms2ly2udY1aGzqTPP8PFkcdYfgf04YR9XbOBsCh36KShRFnosylzP65hF6Q1k4ckeUFEVWFnVOVHGkdPAxBmzVEGwP4U4JruZJUIdJUHPMSkh1mARVUd3rB_Wp6dH8rfoTPQEfjwDSd-wtBhW1nXM3NlDmynj73xYfHiloGgSrobvFO4z_XqNipvhRZNaYV1Ko8t8e-t4f</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Groll, Andreas H, Prof</creator><creator>Castagnola, Elio, Prof</creator><creator>Cesaro, Simone, Prof</creator><creator>Dalle, Jean-Hugues, MD</creator><creator>Engelhard, Dan, Prof</creator><creator>Hope, William, Prof</creator><creator>Roilides, Emmanuel, Prof</creator><creator>Styczynski, Jan, Prof</creator><creator>Warris, Adilia, MD</creator><creator>Lehrnbecher, Thomas, Prof</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140701</creationdate><title>Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation</title><author>Groll, Andreas H, Prof ; Castagnola, Elio, Prof ; Cesaro, Simone, Prof ; Dalle, Jean-Hugues, MD ; Engelhard, Dan, Prof ; Hope, William, Prof ; Roilides, Emmanuel, Prof ; Styczynski, Jan, Prof ; Warris, Adilia, MD ; Lehrnbecher, Thomas, Prof</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-b9e849e51ad789bdd0f0d672baf7d9d7dcbe6ac7cfc45248f34f3cc9aceb92c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Antifungal Agents - 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Apart from differences in underlying disorders and comorbidities relative to those of adults, IFDs in infants, children, and adolescents are unique with respect to their epidemiology, the usefulness of diagnostic methods, the pharmacology and dosing of antifungal agents, and the absence of interventional phase 3 clinical trials for guidance of evidence-based decisions. To better define the state of knowledge on IFDs in paediatric patients with cancer and allogeneic HSCT and to improve IFD diagnosis, prevention, and management, the Fourth European Conference on Infections in Leukaemia (ECIL-4) in 2011 convened a group that reviewed the scientific literature on IFDs and graded the available quality of evidence according to the Infectious Diseases Society of America grading system. The final considerations and recommendations of the group are summarised in this manuscript.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24988936</pmid><doi>10.1016/S1470-2045(14)70017-8</doi></addata></record> |
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| issn | 1470-2045 1474-5488 |
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| subjects | Adolescent Antifungal Agents - therapeutic use Cancer Child Child, Preschool Disease prevention Drug dosages Epidemiology Hematology, Oncology and Palliative Medicine Hematopoietic Stem Cell Transplantation - adverse effects Humans Infant Leukemia - complications Mortality Mycoses - diagnosis Mycoses - drug therapy Mycoses - epidemiology Mycoses - etiology Mycoses - prevention & control Opportunistic Infections - diagnosis Opportunistic Infections - drug therapy Opportunistic Infections - epidemiology Opportunistic Infections - etiology Opportunistic Infections - prevention & control Regulatory approval Risk factors Transplantation, Homologous |
| title | Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation |
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