Tight relationships between B lymphocytes and the skeletal system

Highlights • Deficiency in osteoblasts or osteocytes results in impaired B cell function. • Perturbation of B lymphopoiesis has been linked to changes in bone mass. • B cell derived osteoprotegerin is important for maintenance of the bone. • B cell depletion therapy in rheumatoid arthritis reduces j...

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Veröffentlicht in:	Trends in molecular medicine 2014-07, Vol.20 (7), p.405-412
Hauptverfasser:	Manilay, Jennifer O, Zouali, Moncef
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology B lymphocyte B-Lymphocytes - immunology B-Lymphocytes - pathology Bone and Bones - immunology Bone and Bones - pathology Cell Communication Humans Immune System - immunology Immune System - pathology osteoblast osteoclast Osteoclasts - immunology Osteoclasts - pathology osteocyte osteoimmunology Pathology Periodontitis - immunology Periodontitis - pathology
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Beschreibung
Zusammenfassung:	Highlights • Deficiency in osteoblasts or osteocytes results in impaired B cell function. • Perturbation of B lymphopoiesis has been linked to changes in bone mass. • B cell derived osteoprotegerin is important for maintenance of the bone. • B cell depletion therapy in rheumatoid arthritis reduces joint destruction.
ISSN:	1471-4914 1471-499X
DOI:	10.1016/j.molmed.2014.03.003