Wound healing properties of quince seed mucilage: In vivo evaluation in rabbit full-thickness wound model
Abstract Objective Quince seed mucilage (QSM) has been used in Iranian traditional medicine for the treatment of skin wounds and burns. Recent studies indicated that QSM accelerated wound healing. The present study was undertaken to investigate the healing efficiency of QSM formulated as 5%, 10%, an...
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| Veröffentlicht in: | International journal of surgery (London, England) England), 2014-01, Vol.12 (8), p.843-847 |
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| creator | Tamri, Pari Hemmati, Aliasghar Boroujerdnia, Mehri Ghafourian |
| description | Abstract Objective Quince seed mucilage (QSM) has been used in Iranian traditional medicine for the treatment of skin wounds and burns. Recent studies indicated that QSM accelerated wound healing. The present study was undertaken to investigate the healing efficiency of QSM formulated as 5%, 10%, and 20% creams in eucerin base with especial attention on growth factors involving in wound healing. Methods Full thickness wounds were created in Iranian male rabbits divided into five experimental groups ( n = 6), as negative control, eucerin and treatments. Negative control group did not receive any treatment. Eucerin group received topical eucerin, twice a day. Treatment groups were treated topically by creams of QSM 5%, 10% and 20% (w/w) in eucerin base, twice daily. The efficacy of treatment was evaluated based on wound contraction, haydroxyproline content, tensile strength of wound tissue. The levels of epidermal growth factor (EGF), transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) were also determined in serum and wound fluid of tested animals. Results Results showed that there were statistically significant differences in wound contraction between QSM 10 and 20% creams treatments groups and control groups ( P |
| doi_str_mv | 10.1016/j.ijsu.2014.06.016 |
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Recent studies indicated that QSM accelerated wound healing. The present study was undertaken to investigate the healing efficiency of QSM formulated as 5%, 10%, and 20% creams in eucerin base with especial attention on growth factors involving in wound healing. Methods Full thickness wounds were created in Iranian male rabbits divided into five experimental groups ( n = 6), as negative control, eucerin and treatments. Negative control group did not receive any treatment. Eucerin group received topical eucerin, twice a day. Treatment groups were treated topically by creams of QSM 5%, 10% and 20% (w/w) in eucerin base, twice daily. The efficacy of treatment was evaluated based on wound contraction, haydroxyproline content, tensile strength of wound tissue. The levels of epidermal growth factor (EGF), transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) were also determined in serum and wound fluid of tested animals. Results Results showed that there were statistically significant differences in wound contraction between QSM 10 and 20% creams treatments groups and control groups ( P < 0.05) in most of the days. Rabbits treated with QSM 20% cream had the best results (completed healing in 13 days, higher hydroxyproline content, higher tissue resistance and higher wound fluid levels of evaluated growth factors). Conclusion We concluded tha QSM in 10–20% concentrations have a good potential for promote wound healing thus supports its traditional use.</description><identifier>ISSN: 1743-9191</identifier><identifier>EISSN: 1743-9159</identifier><identifier>DOI: 10.1016/j.ijsu.2014.06.016</identifier><identifier>PMID: 25017948</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Growth factors ; Male ; Plant Mucilage - administration & dosage ; Platelet-Derived Growth Factor - metabolism ; Quince seed mucilage ; Rabbit ; Rabbits ; Rosaceae ; Seeds ; Skin - injuries ; Skin Cream - administration & dosage ; Surgery ; Tensile Strength ; Transforming Growth Factor beta1 - metabolism ; Vascular Endothelial Growth Factor A - metabolism ; Wound fluid ; Wound healing ; Wound Healing - drug effects ; Wounds and Injuries - metabolism</subject><ispartof>International journal of surgery (London, England), 2014-01, Vol.12 (8), p.843-847</ispartof><rights>Surgical Associates Ltd</rights><rights>2014 Surgical Associates Ltd</rights><rights>Copyright © 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-5c021f58eed84f555c37091212b4b283ee074ed7a96dfef8c4739586cc52f4d13</citedby><cites>FETCH-LOGICAL-c521t-5c021f58eed84f555c37091212b4b283ee074ed7a96dfef8c4739586cc52f4d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijsu.2014.06.016$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25017948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tamri, Pari</creatorcontrib><creatorcontrib>Hemmati, Aliasghar</creatorcontrib><creatorcontrib>Boroujerdnia, Mehri Ghafourian</creatorcontrib><title>Wound healing properties of quince seed mucilage: In vivo evaluation in rabbit full-thickness wound model</title><title>International journal of surgery (London, England)</title><addtitle>Int J Surg</addtitle><description>Abstract Objective Quince seed mucilage (QSM) has been used in Iranian traditional medicine for the treatment of skin wounds and burns. Recent studies indicated that QSM accelerated wound healing. The present study was undertaken to investigate the healing efficiency of QSM formulated as 5%, 10%, and 20% creams in eucerin base with especial attention on growth factors involving in wound healing. Methods Full thickness wounds were created in Iranian male rabbits divided into five experimental groups ( n = 6), as negative control, eucerin and treatments. Negative control group did not receive any treatment. Eucerin group received topical eucerin, twice a day. Treatment groups were treated topically by creams of QSM 5%, 10% and 20% (w/w) in eucerin base, twice daily. The efficacy of treatment was evaluated based on wound contraction, haydroxyproline content, tensile strength of wound tissue. The levels of epidermal growth factor (EGF), transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) were also determined in serum and wound fluid of tested animals. Results Results showed that there were statistically significant differences in wound contraction between QSM 10 and 20% creams treatments groups and control groups ( P < 0.05) in most of the days. Rabbits treated with QSM 20% cream had the best results (completed healing in 13 days, higher hydroxyproline content, higher tissue resistance and higher wound fluid levels of evaluated growth factors). Conclusion We concluded tha QSM in 10–20% concentrations have a good potential for promote wound healing thus supports its traditional use.</description><subject>Animals</subject><subject>Growth factors</subject><subject>Male</subject><subject>Plant Mucilage - administration & dosage</subject><subject>Platelet-Derived Growth Factor - metabolism</subject><subject>Quince seed mucilage</subject><subject>Rabbit</subject><subject>Rabbits</subject><subject>Rosaceae</subject><subject>Seeds</subject><subject>Skin - injuries</subject><subject>Skin Cream - administration & dosage</subject><subject>Surgery</subject><subject>Tensile Strength</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>Wound fluid</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>Wounds and Injuries - metabolism</subject><issn>1743-9191</issn><issn>1743-9159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uFiEYhYnR2B-9AReGpZsZgYH5McbENFabNHGhxiVh4KVlygxfYfhM78Zr8cpk_GoXLtwAeXPOIe9zEHpBSU0JbV9PtZtSrhmhvCZtXUaP0DHteFMNVAyPH94DPUInKU2EcNLT_ik6YoLQbuD9MZq-h7wYfA3Ku-UK72LYQVwdJBwsvs1u0YATgMFz1s6rK3iDL5ZfP_duHzDslc9qdWHBbsFRjaNbsc3eV-u10zcLpIR__ImfgwH_DD2xyid4fn-fom_nH76efaouP3-8OHt_WWnB6FoJTRi1oi-f9twKIXTTkYEyykY-sr4BIB0H06mhNRZsr3nXDKJvdbFbbmhzil4dcssytxnSKmeXNHivFgg5SSoE60lXziJlB6mOIaUIVu6im1W8k5TIjbGc5MZYbowlaWUZFdPL-_w8zmAeLH-hFsHbgwDKlnsHUSbtoJA0LoJepQnu__nv_rHr0o3Tyt_AHaQp5LgUfpLKxCSRX7aWt5IpJ4SRZmh-A5UIpDM</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Tamri, Pari</creator><creator>Hemmati, Aliasghar</creator><creator>Boroujerdnia, Mehri Ghafourian</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Wound healing properties of quince seed mucilage: In vivo evaluation in rabbit full-thickness wound model</title><author>Tamri, Pari ; Hemmati, Aliasghar ; Boroujerdnia, Mehri Ghafourian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-5c021f58eed84f555c37091212b4b283ee074ed7a96dfef8c4739586cc52f4d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Growth factors</topic><topic>Male</topic><topic>Plant Mucilage - administration & dosage</topic><topic>Platelet-Derived Growth Factor - metabolism</topic><topic>Quince seed mucilage</topic><topic>Rabbit</topic><topic>Rabbits</topic><topic>Rosaceae</topic><topic>Seeds</topic><topic>Skin - injuries</topic><topic>Skin Cream - administration & dosage</topic><topic>Surgery</topic><topic>Tensile Strength</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>Wound fluid</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>Wounds and Injuries - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamri, Pari</creatorcontrib><creatorcontrib>Hemmati, Aliasghar</creatorcontrib><creatorcontrib>Boroujerdnia, Mehri Ghafourian</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgery (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamri, Pari</au><au>Hemmati, Aliasghar</au><au>Boroujerdnia, Mehri Ghafourian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wound healing properties of quince seed mucilage: In vivo evaluation in rabbit full-thickness wound model</atitle><jtitle>International journal of surgery (London, England)</jtitle><addtitle>Int J Surg</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>12</volume><issue>8</issue><spage>843</spage><epage>847</epage><pages>843-847</pages><issn>1743-9191</issn><eissn>1743-9159</eissn><abstract>Abstract Objective Quince seed mucilage (QSM) has been used in Iranian traditional medicine for the treatment of skin wounds and burns. Recent studies indicated that QSM accelerated wound healing. The present study was undertaken to investigate the healing efficiency of QSM formulated as 5%, 10%, and 20% creams in eucerin base with especial attention on growth factors involving in wound healing. Methods Full thickness wounds were created in Iranian male rabbits divided into five experimental groups ( n = 6), as negative control, eucerin and treatments. Negative control group did not receive any treatment. Eucerin group received topical eucerin, twice a day. Treatment groups were treated topically by creams of QSM 5%, 10% and 20% (w/w) in eucerin base, twice daily. The efficacy of treatment was evaluated based on wound contraction, haydroxyproline content, tensile strength of wound tissue. The levels of epidermal growth factor (EGF), transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) were also determined in serum and wound fluid of tested animals. Results Results showed that there were statistically significant differences in wound contraction between QSM 10 and 20% creams treatments groups and control groups ( P < 0.05) in most of the days. Rabbits treated with QSM 20% cream had the best results (completed healing in 13 days, higher hydroxyproline content, higher tissue resistance and higher wound fluid levels of evaluated growth factors). Conclusion We concluded tha QSM in 10–20% concentrations have a good potential for promote wound healing thus supports its traditional use.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25017948</pmid><doi>10.1016/j.ijsu.2014.06.016</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Growth factors Male Plant Mucilage - administration & dosage Platelet-Derived Growth Factor - metabolism Quince seed mucilage Rabbit Rabbits Rosaceae Seeds Skin - injuries Skin Cream - administration & dosage Surgery Tensile Strength Transforming Growth Factor beta1 - metabolism Vascular Endothelial Growth Factor A - metabolism Wound fluid Wound healing Wound Healing - drug effects Wounds and Injuries - metabolism |
| title | Wound healing properties of quince seed mucilage: In vivo evaluation in rabbit full-thickness wound model |
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