Influence of a dual-injection regimen, plerixafor and CXCR4 on in utero hematopoietic stem cell transplantation and engraftment with use of the sheep model

Abstract Background aims Inadequate engraftment of hematopoietic stem cells (HSCs) after in utero HSC transplantation (IUHSCT) remains a major obstacle for the prenatal correction of numerous hereditary disorders. HSCs express CXCR4 receptors that allow homing and engraftment in response to stromal-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cytotherapy (Oxford, England) England), 2014-09, Vol.16 (9), p.1280-1293
Hauptverfasser:	Goodrich, A. Daisy, Varain, Nicole M, Jeanblanc, Christine M, Colon, Donna M, Kim, Jaehyup, Zanjani, Esmail D, Hematti, Peiman
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Antigens, CD34 - metabolism Benzylamines Cell Differentiation Cell Lineage Cells, Cultured Chemokine CXCL12 - metabolism Clinical Protocols CXCR4 Cyclams Disease Models, Animal Female Fetus Genetic Diseases, Inborn - therapy Graft Survival Hematopoietic Stem Cell Transplantation Heterocyclic Compounds - administration & dosage Humans Immunomodulation in utero transplantation Mesenchymal Stem Cells - physiology Other plerixafor Pregnancy Receptors, CXCR4 - administration & dosage SDF-1 Sheep sheep model
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!