Endogenous endothelin 1 mediates angiotensin II-induced hypertrophy in electrically paced cardiac myocytes through EGFR transactivation, reactive oxygen species and NHE-1

Emerging evidence supports a key role for endothelin-1 (ET-1) and the transactivation of the epidermal growth factor receptor (EGFR) in angiotensin II (Ang II) action. We aim to determine the potential role played by endogenous ET-1, EGFR transactivation and redox-dependent sodium hydrogen exchanger...

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Veröffentlicht in:	Pflügers Archiv 2014-09, Vol.466 (9), p.1819-1830
Hauptverfasser:	Correa, María V., Nolly, Mariela B., Caldiz, Claudia I., de Cingolani, Gladys E. Chiappe, Cingolani, Horacio E., Ennis, Irene L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Animals Biomedical and Life Sciences Biomedicine Blotting, Western Cardiomegaly - metabolism Cats Cell Biology Disease Models, Animal Electric Stimulation Endothelin-1 - metabolism Human Physiology Hypertrophy - metabolism Molecular and Cellular Mechanisms of Disease Molecular Medicine Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Neurosciences Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Receptor, Epidermal Growth Factor - metabolism Receptors Signal Transduction - physiology Sodium-Hydrogen Exchangers - metabolism Transcriptional Activation
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