Bile acids increase the activity of the epithelial Na+ channel
The epithelial Na + channel (ENaC) is a key regulator of Na + absorption in various epithelia including the distal nephron and the distal colon. ENaC is a constitutively active channel, but its activity is modulated by a number of mechanisms. These include proteolytic activation, ubiquitination and...
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| Veröffentlicht in: | Pflügers Archiv 2014-09, Vol.466 (9), p.1725-1733 |
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| creator | Wiemuth, Dominik Lefèvre, Cathérine M. T. Heidtmann, Hannelore Gründer, Stefan |
| description | The epithelial Na
+
channel (ENaC) is a key regulator of Na
+
absorption in various epithelia including the distal nephron and the distal colon. ENaC is a constitutively active channel, but its activity is modulated by a number of mechanisms. These include proteolytic activation, ubiquitination and cell surface expression, phosphorylation, intracellular Na
+
concentration, and shear stress. ENaC is related to the bile acid-sensitive ion channel (BASIC), a channel that is expressed in the epithelial cells of bile ducts. BASIC is activated by millimolar concentrations of extracellular bile acids. Bile acids are synthesized by the liver and secreted into the duodenum to aid lipolysis. A large fraction of the secreted bile acids is absorbed by the ileum and recirculated into the liver, but a small fraction passes the colon and is excreted. Bile acids can influence the ion transport processes in the intestinal tract including the colon. In this study, we show that various bile acids present in rat bile potently and reversibly increase the activity of rat ENaC expressed in
Xenopus
oocytes, suggesting that bile acids are natural modulators of ENaC activity. |
| doi_str_mv | 10.1007/s00424-013-1403-0 |
| format | Article |
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+
channel (ENaC) is a key regulator of Na
+
absorption in various epithelia including the distal nephron and the distal colon. ENaC is a constitutively active channel, but its activity is modulated by a number of mechanisms. These include proteolytic activation, ubiquitination and cell surface expression, phosphorylation, intracellular Na
+
concentration, and shear stress. ENaC is related to the bile acid-sensitive ion channel (BASIC), a channel that is expressed in the epithelial cells of bile ducts. BASIC is activated by millimolar concentrations of extracellular bile acids. Bile acids are synthesized by the liver and secreted into the duodenum to aid lipolysis. A large fraction of the secreted bile acids is absorbed by the ileum and recirculated into the liver, but a small fraction passes the colon and is excreted. Bile acids can influence the ion transport processes in the intestinal tract including the colon. In this study, we show that various bile acids present in rat bile potently and reversibly increase the activity of rat ENaC expressed in
Xenopus
oocytes, suggesting that bile acids are natural modulators of ENaC activity.</description><identifier>ISSN: 0031-6768</identifier><identifier>EISSN: 1432-2013</identifier><identifier>DOI: 10.1007/s00424-013-1403-0</identifier><identifier>PMID: 24292109</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Bile - chemistry ; Bile - metabolism ; Bile Acids and Salts - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Epithelial Sodium Channels - metabolism ; Human Physiology ; Ion Channels ; Ion Transport - physiology ; Molecular Medicine ; Neurosciences ; Patch-Clamp Techniques ; Rats ; Receptors ; Receptors and Transporters</subject><ispartof>Pflügers Archiv, 2014-09, Vol.466 (9), p.1725-1733</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-d7526c345ad85d76c8ceae0059a5c22ddaf39c009b5d4450f9aeda106c28c523</citedby><cites>FETCH-LOGICAL-c491t-d7526c345ad85d76c8ceae0059a5c22ddaf39c009b5d4450f9aeda106c28c523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00424-013-1403-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00424-013-1403-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24292109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wiemuth, Dominik</creatorcontrib><creatorcontrib>Lefèvre, Cathérine M. T.</creatorcontrib><creatorcontrib>Heidtmann, Hannelore</creatorcontrib><creatorcontrib>Gründer, Stefan</creatorcontrib><title>Bile acids increase the activity of the epithelial Na+ channel</title><title>Pflügers Archiv</title><addtitle>Pflugers Arch - Eur J Physiol</addtitle><addtitle>Pflugers Arch</addtitle><description>The epithelial Na
+
channel (ENaC) is a key regulator of Na
+
absorption in various epithelia including the distal nephron and the distal colon. ENaC is a constitutively active channel, but its activity is modulated by a number of mechanisms. These include proteolytic activation, ubiquitination and cell surface expression, phosphorylation, intracellular Na
+
concentration, and shear stress. ENaC is related to the bile acid-sensitive ion channel (BASIC), a channel that is expressed in the epithelial cells of bile ducts. BASIC is activated by millimolar concentrations of extracellular bile acids. Bile acids are synthesized by the liver and secreted into the duodenum to aid lipolysis. A large fraction of the secreted bile acids is absorbed by the ileum and recirculated into the liver, but a small fraction passes the colon and is excreted. Bile acids can influence the ion transport processes in the intestinal tract including the colon. In this study, we show that various bile acids present in rat bile potently and reversibly increase the activity of rat ENaC expressed in
Xenopus
oocytes, suggesting that bile acids are natural modulators of ENaC activity.</description><subject>Animals</subject><subject>Bile - chemistry</subject><subject>Bile - metabolism</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Epithelial Sodium Channels - metabolism</subject><subject>Human Physiology</subject><subject>Ion Channels</subject><subject>Ion Transport - physiology</subject><subject>Molecular Medicine</subject><subject>Neurosciences</subject><subject>Patch-Clamp Techniques</subject><subject>Rats</subject><subject>Receptors</subject><subject>Receptors and Transporters</subject><issn>0031-6768</issn><issn>1432-2013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0EglL4AVxQjkjIsN7YeVyQoOIlVXDp3XJth7pKk2InSP33OKRw5DTa3ZmR9iPkgsENA8hvAwBHToGllHFIKRyQCeMpUoyrQzIBSBnN8qw4IachrAEAeYHH5AQ5lsignJC7B1fbRGlnQuIa7a0KNulWw6pzX67bJW31M9uti1I7VSdv6jrRK9U0tj4jR5Wqgz3f65Qsnh4Xsxc6f39-nd3PqeYl66jJBWY65UKZQpg804W2ygKIUgmNaIyq0lIDlEthOBdQlcoaxSDTWGiB6ZRcjbVb3372NnRy44K2da0a2_ZBMiGwgBiEaGWjVfs2BG8rufVuo_xOMpADNTlSkxGRHKjJIXO5r--XG2v-Er-YogFHQ4in5sN6uW5738SP_2n9BvaSdg4</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Wiemuth, Dominik</creator><creator>Lefèvre, Cathérine M. T.</creator><creator>Heidtmann, Hannelore</creator><creator>Gründer, Stefan</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Bile acids increase the activity of the epithelial Na+ channel</title><author>Wiemuth, Dominik ; Lefèvre, Cathérine M. T. ; Heidtmann, Hannelore ; Gründer, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-d7526c345ad85d76c8ceae0059a5c22ddaf39c009b5d4450f9aeda106c28c523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Bile - chemistry</topic><topic>Bile - metabolism</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Epithelial Sodium Channels - metabolism</topic><topic>Human Physiology</topic><topic>Ion Channels</topic><topic>Ion Transport - physiology</topic><topic>Molecular Medicine</topic><topic>Neurosciences</topic><topic>Patch-Clamp Techniques</topic><topic>Rats</topic><topic>Receptors</topic><topic>Receptors and Transporters</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wiemuth, Dominik</creatorcontrib><creatorcontrib>Lefèvre, Cathérine M. T.</creatorcontrib><creatorcontrib>Heidtmann, Hannelore</creatorcontrib><creatorcontrib>Gründer, Stefan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pflügers Archiv</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wiemuth, Dominik</au><au>Lefèvre, Cathérine M. T.</au><au>Heidtmann, Hannelore</au><au>Gründer, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bile acids increase the activity of the epithelial Na+ channel</atitle><jtitle>Pflügers Archiv</jtitle><stitle>Pflugers Arch - Eur J Physiol</stitle><addtitle>Pflugers Arch</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>466</volume><issue>9</issue><spage>1725</spage><epage>1733</epage><pages>1725-1733</pages><issn>0031-6768</issn><eissn>1432-2013</eissn><abstract>The epithelial Na
+
channel (ENaC) is a key regulator of Na
+
absorption in various epithelia including the distal nephron and the distal colon. ENaC is a constitutively active channel, but its activity is modulated by a number of mechanisms. These include proteolytic activation, ubiquitination and cell surface expression, phosphorylation, intracellular Na
+
concentration, and shear stress. ENaC is related to the bile acid-sensitive ion channel (BASIC), a channel that is expressed in the epithelial cells of bile ducts. BASIC is activated by millimolar concentrations of extracellular bile acids. Bile acids are synthesized by the liver and secreted into the duodenum to aid lipolysis. A large fraction of the secreted bile acids is absorbed by the ileum and recirculated into the liver, but a small fraction passes the colon and is excreted. Bile acids can influence the ion transport processes in the intestinal tract including the colon. In this study, we show that various bile acids present in rat bile potently and reversibly increase the activity of rat ENaC expressed in
Xenopus
oocytes, suggesting that bile acids are natural modulators of ENaC activity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24292109</pmid><doi>10.1007/s00424-013-1403-0</doi><tpages>9</tpages></addata></record> |
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| ispartof | Pflügers Archiv, 2014-09, Vol.466 (9), p.1725-1733 |
| issn | 0031-6768 1432-2013 |
| language | eng |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Animals Bile - chemistry Bile - metabolism Bile Acids and Salts - metabolism Biomedical and Life Sciences Biomedicine Cell Biology Epithelial Sodium Channels - metabolism Human Physiology Ion Channels Ion Transport - physiology Molecular Medicine Neurosciences Patch-Clamp Techniques Rats Receptors Receptors and Transporters |
| title | Bile acids increase the activity of the epithelial Na+ channel |
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