Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals
Purpose Concurrent infection with HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) often occurs due to the commonality in risk factors for acquisition. Few studies have examined the effect of co-infection on health-related quality of life (HRQOL) in HIV positive individuals. Methods Ontario...
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| Veröffentlicht in: | Quality of life research 2013-09, Vol.22 (7), p.1525-1535 |
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| creator | Gillis, Jennifer Cooper, Curtis Rourke, Sean Rueda, Sergio O'Brien, Kelly Collins, Evan Rachlis, Anita Hart, Trevor A. Raboud, Janet |
| description | Purpose Concurrent infection with HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) often occurs due to the commonality in risk factors for acquisition. Few studies have examined the effect of co-infection on health-related quality of life (HRQOL) in HIV positive individuals. Methods Ontario HIV Treatment Network Cohort Study (OCS) participants who completed an annual interviewer-administered questionnaire on up to three occasions were included. Generalized estimating equations (GEE) were used to assess the impact of HBV and HCV co-infection on physical and mental HRQOL component summary scores (range 0–100) as measured by the Medical Outcomes SF-36 health survey. Results As of March 2010, 1,223 participants had completed the questionnaire; 964 were HIV mono-infected, 128 were HIV–HBV co-infected, 112 were HIV–HCV co-infected, and 19 were HIV–HBV–HCV tri-infected. Eighty percent were male, median age 46 (IQR 40–53) years, 61 % Caucasian, median CD4 count 464 (IQR 319–636) cells/mm3, and 74 % had undetectable HIV viremia. Physical HRQOL was lower in HIV–HBV and HIV–HCV co-infected individuals (49.4 (IQR 42.0–53.9) and 48.1 (IQR 36.9–52.8) vs. 51.5 (IQR 45.0–55.4); p = 0.01 and |
| doi_str_mv | 10.1007/s11136-012-0283-7 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1552378255</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>24725187</jstor_id><sourcerecordid>24725187</sourcerecordid><originalsourceid>FETCH-LOGICAL-c460t-db1a879b945f8fbc62308f036927c2e19cc0716ecd2bcc37ed2a67caf1d82c0a3</originalsourceid><addsrcrecordid>eNqNkUtr3DAUhUVpaaZpf0AXLYJuulF7JdmStWyGpBkIZJN2K2Q9Oho8tmPJgfz7yjh90EUTEFyEvnPuEQehtxQ-UQD5OVFKuSBAGQHWcCKfoQ2tJSdMVOo52oASjChe8RP0KqUDADQK2Et0wjhIkJXaoLA7jsZmPAS896PJMceEz7DpHd5iO5DYB29zHHpczt6bLu_J5DuTvcO3s-livl-0XQwexx5f7r7jcUjF5W65u3gXXaHSa_QilOHfPMxT9O3i_GZ7Sa6uv-62X66IrQRk4lpqGqlaVdWhCa0VJWgTgAvFpGWeKmtBUuGtY621XHrHjJDWBOoaZsHwU_Rx9R2n4Xb2KetjTNZ3nen9MCdN65px2bC6fhytqoZRVeI8AS0xa05BFvTDP-hhmKe-_HmhOIiaAi8UXSk7DSlNPuhxikcz3WsKeqlWr9XqUq1eqtWL8_sH57k9evdb8avLArAVSOWp_-Gnv1b_x_XdKjqkPEx_TCvJatpI_hP7YLZG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1433065103</pqid></control><display><type>article</type><title>Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals</title><source>MEDLINE</source><source>SpringerLink_现刊</source><source>JSTOR</source><creator>Gillis, Jennifer ; Cooper, Curtis ; Rourke, Sean ; Rueda, Sergio ; O'Brien, Kelly ; Collins, Evan ; Rachlis, Anita ; Hart, Trevor A. ; Raboud, Janet</creator><creatorcontrib>Gillis, Jennifer ; Cooper, Curtis ; Rourke, Sean ; Rueda, Sergio ; O'Brien, Kelly ; Collins, Evan ; Rachlis, Anita ; Hart, Trevor A. ; Raboud, Janet ; OHTN Cohort Study Group ; OHTN Cohort Study Group ; the OHTN Cohort Study Group</creatorcontrib><description>Purpose Concurrent infection with HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) often occurs due to the commonality in risk factors for acquisition. Few studies have examined the effect of co-infection on health-related quality of life (HRQOL) in HIV positive individuals. Methods Ontario HIV Treatment Network Cohort Study (OCS) participants who completed an annual interviewer-administered questionnaire on up to three occasions were included. Generalized estimating equations (GEE) were used to assess the impact of HBV and HCV co-infection on physical and mental HRQOL component summary scores (range 0–100) as measured by the Medical Outcomes SF-36 health survey. Results As of March 2010, 1,223 participants had completed the questionnaire; 964 were HIV mono-infected, 128 were HIV–HBV co-infected, 112 were HIV–HCV co-infected, and 19 were HIV–HBV–HCV tri-infected. Eighty percent were male, median age 46 (IQR 40–53) years, 61 % Caucasian, median CD4 count 464 (IQR 319–636) cells/mm3, and 74 % had undetectable HIV viremia. Physical HRQOL was lower in HIV–HBV and HIV–HCV co-infected individuals (49.4 (IQR 42.0–53.9) and 48.1 (IQR 36.9–52.8) vs. 51.5 (IQR 45.0–55.4); p = 0.01 and <0.0001) compared to mono-infected individuals. In the multivariable GEE model, the negative impact of HCV remained significant (−2.18; p = 0.01) after adjusting for drug use, smoking, age, and gender. Unadjusted mental HRQOL was lower in HIV–HCV co-infected individuals (44.6 (IQR 34.6–54.0) vs. 48.9 (IQR 36.8–55.9); p = 0.03) compared to mono-infected individuals but no association of mental HRQOL with either co-infection was observed in multivariable GEE models. Conclusions HCV appears to negatively impact physical HRQOL suggesting a greater health burden for co-infected individuals. HBV and HCV co-infections were not related to lower mental HRQOL among people living with HIV/AIDS.</description><identifier>ISSN: 0962-9343</identifier><identifier>EISSN: 1573-2649</identifier><identifier>DOI: 10.1007/s11136-012-0283-7</identifier><identifier>PMID: 23070749</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Acquired immune deficiency syndrome ; Adult ; Alcohol drinking ; CD4 Lymphocyte Count ; Cohort analysis ; Cohort Studies ; Coinfection ; Comorbidity ; Coping ; Demography ; Drug use ; Female ; Health care networks ; Health Status ; Health surveys ; Hepatitis ; Hepatitis B ; Hepatitis B - complications ; Hepatitis B virus ; Hepatitis C ; Hepatitis C - complications ; HIV ; HIV Infections - complications ; HIV Infections - psychology ; HIV Infections - virology ; HIV-1 - isolation & purification ; Hospitals ; Human immunodeficiency virus ; Humans ; Income estimates ; Infections ; Infectious diseases ; Laboratories ; Liver diseases ; Male ; Medicine ; Medicine & Public Health ; Mental depression ; Mental health ; Middle Aged ; Ontario ; P values ; Public Health ; Quality of Life ; Quality of Life Research ; Questionnaires ; Sickness Impact Profile ; Sociodemographics ; Socioeconomic Factors ; Sociology ; Standard scores ; Stigma ; Surveys and Questionnaires ; Tranquilizing agents ; Viral Load ; Viremia - complications ; Viremia - immunology</subject><ispartof>Quality of life research, 2013-09, Vol.22 (7), p.1525-1535</ispartof><rights>Springer Science+Business Media Dordrecht 2012</rights><rights>Springer Science+Business Media Dordrecht 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-db1a879b945f8fbc62308f036927c2e19cc0716ecd2bcc37ed2a67caf1d82c0a3</citedby><cites>FETCH-LOGICAL-c460t-db1a879b945f8fbc62308f036927c2e19cc0716ecd2bcc37ed2a67caf1d82c0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24725187$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24725187$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,27926,27927,41490,42559,51321,58019,58252</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23070749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gillis, Jennifer</creatorcontrib><creatorcontrib>Cooper, Curtis</creatorcontrib><creatorcontrib>Rourke, Sean</creatorcontrib><creatorcontrib>Rueda, Sergio</creatorcontrib><creatorcontrib>O'Brien, Kelly</creatorcontrib><creatorcontrib>Collins, Evan</creatorcontrib><creatorcontrib>Rachlis, Anita</creatorcontrib><creatorcontrib>Hart, Trevor A.</creatorcontrib><creatorcontrib>Raboud, Janet</creatorcontrib><creatorcontrib>OHTN Cohort Study Group</creatorcontrib><creatorcontrib>OHTN Cohort Study Group</creatorcontrib><creatorcontrib>the OHTN Cohort Study Group</creatorcontrib><title>Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals</title><title>Quality of life research</title><addtitle>Qual Life Res</addtitle><addtitle>Qual Life Res</addtitle><description>Purpose Concurrent infection with HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) often occurs due to the commonality in risk factors for acquisition. Few studies have examined the effect of co-infection on health-related quality of life (HRQOL) in HIV positive individuals. Methods Ontario HIV Treatment Network Cohort Study (OCS) participants who completed an annual interviewer-administered questionnaire on up to three occasions were included. Generalized estimating equations (GEE) were used to assess the impact of HBV and HCV co-infection on physical and mental HRQOL component summary scores (range 0–100) as measured by the Medical Outcomes SF-36 health survey. Results As of March 2010, 1,223 participants had completed the questionnaire; 964 were HIV mono-infected, 128 were HIV–HBV co-infected, 112 were HIV–HCV co-infected, and 19 were HIV–HBV–HCV tri-infected. Eighty percent were male, median age 46 (IQR 40–53) years, 61 % Caucasian, median CD4 count 464 (IQR 319–636) cells/mm3, and 74 % had undetectable HIV viremia. Physical HRQOL was lower in HIV–HBV and HIV–HCV co-infected individuals (49.4 (IQR 42.0–53.9) and 48.1 (IQR 36.9–52.8) vs. 51.5 (IQR 45.0–55.4); p = 0.01 and <0.0001) compared to mono-infected individuals. In the multivariable GEE model, the negative impact of HCV remained significant (−2.18; p = 0.01) after adjusting for drug use, smoking, age, and gender. Unadjusted mental HRQOL was lower in HIV–HCV co-infected individuals (44.6 (IQR 34.6–54.0) vs. 48.9 (IQR 36.8–55.9); p = 0.03) compared to mono-infected individuals but no association of mental HRQOL with either co-infection was observed in multivariable GEE models. Conclusions HCV appears to negatively impact physical HRQOL suggesting a greater health burden for co-infected individuals. HBV and HCV co-infections were not related to lower mental HRQOL among people living with HIV/AIDS.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>Alcohol drinking</subject><subject>CD4 Lymphocyte Count</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Coinfection</subject><subject>Comorbidity</subject><subject>Coping</subject><subject>Demography</subject><subject>Drug use</subject><subject>Female</subject><subject>Health care networks</subject><subject>Health Status</subject><subject>Health surveys</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B virus</subject><subject>Hepatitis C</subject><subject>Hepatitis C - complications</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - psychology</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - isolation & purification</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Income estimates</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Laboratories</subject><subject>Liver diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Mental health</subject><subject>Middle Aged</subject><subject>Ontario</subject><subject>P values</subject><subject>Public Health</subject><subject>Quality of Life</subject><subject>Quality of Life Research</subject><subject>Questionnaires</subject><subject>Sickness Impact Profile</subject><subject>Sociodemographics</subject><subject>Socioeconomic Factors</subject><subject>Sociology</subject><subject>Standard scores</subject><subject>Stigma</subject><subject>Surveys and Questionnaires</subject><subject>Tranquilizing agents</subject><subject>Viral Load</subject><subject>Viremia - complications</subject><subject>Viremia - immunology</subject><issn>0962-9343</issn><issn>1573-2649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUtr3DAUhUVpaaZpf0AXLYJuulF7JdmStWyGpBkIZJN2K2Q9Oho8tmPJgfz7yjh90EUTEFyEvnPuEQehtxQ-UQD5OVFKuSBAGQHWcCKfoQ2tJSdMVOo52oASjChe8RP0KqUDADQK2Et0wjhIkJXaoLA7jsZmPAS896PJMceEz7DpHd5iO5DYB29zHHpczt6bLu_J5DuTvcO3s-livl-0XQwexx5f7r7jcUjF5W65u3gXXaHSa_QilOHfPMxT9O3i_GZ7Sa6uv-62X66IrQRk4lpqGqlaVdWhCa0VJWgTgAvFpGWeKmtBUuGtY621XHrHjJDWBOoaZsHwU_Rx9R2n4Xb2KetjTNZ3nen9MCdN65px2bC6fhytqoZRVeI8AS0xa05BFvTDP-hhmKe-_HmhOIiaAi8UXSk7DSlNPuhxikcz3WsKeqlWr9XqUq1eqtWL8_sH57k9evdb8avLArAVSOWp_-Gnv1b_x_XdKjqkPEx_TCvJatpI_hP7YLZG</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Gillis, Jennifer</creator><creator>Cooper, Curtis</creator><creator>Rourke, Sean</creator><creator>Rueda, Sergio</creator><creator>O'Brien, Kelly</creator><creator>Collins, Evan</creator><creator>Rachlis, Anita</creator><creator>Hart, Trevor A.</creator><creator>Raboud, Janet</creator><general>Springer</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>KB0</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope></search><sort><creationdate>20130901</creationdate><title>Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals</title><author>Gillis, Jennifer ; Cooper, Curtis ; Rourke, Sean ; Rueda, Sergio ; O'Brien, Kelly ; Collins, Evan ; Rachlis, Anita ; Hart, Trevor A. ; Raboud, Janet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-db1a879b945f8fbc62308f036927c2e19cc0716ecd2bcc37ed2a67caf1d82c0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>Alcohol drinking</topic><topic>CD4 Lymphocyte Count</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Coinfection</topic><topic>Comorbidity</topic><topic>Coping</topic><topic>Demography</topic><topic>Drug use</topic><topic>Female</topic><topic>Health care networks</topic><topic>Health Status</topic><topic>Health surveys</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis B virus</topic><topic>Hepatitis C</topic><topic>Hepatitis C - complications</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - psychology</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - isolation & purification</topic><topic>Hospitals</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Income estimates</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Laboratories</topic><topic>Liver diseases</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Mental health</topic><topic>Middle Aged</topic><topic>Ontario</topic><topic>P values</topic><topic>Public Health</topic><topic>Quality of Life</topic><topic>Quality of Life Research</topic><topic>Questionnaires</topic><topic>Sickness Impact Profile</topic><topic>Sociodemographics</topic><topic>Socioeconomic Factors</topic><topic>Sociology</topic><topic>Standard scores</topic><topic>Stigma</topic><topic>Surveys and Questionnaires</topic><topic>Tranquilizing agents</topic><topic>Viral Load</topic><topic>Viremia - complications</topic><topic>Viremia - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gillis, Jennifer</creatorcontrib><creatorcontrib>Cooper, Curtis</creatorcontrib><creatorcontrib>Rourke, Sean</creatorcontrib><creatorcontrib>Rueda, Sergio</creatorcontrib><creatorcontrib>O'Brien, Kelly</creatorcontrib><creatorcontrib>Collins, Evan</creatorcontrib><creatorcontrib>Rachlis, Anita</creatorcontrib><creatorcontrib>Hart, Trevor A.</creatorcontrib><creatorcontrib>Raboud, Janet</creatorcontrib><creatorcontrib>OHTN Cohort Study Group</creatorcontrib><creatorcontrib>OHTN Cohort Study Group</creatorcontrib><creatorcontrib>the OHTN Cohort Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>ABI/INFORM Complete</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest Business Premium Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>Nursing & Allied Health Premium</collection><collection>One Business (ProQuest)</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><jtitle>Quality of life research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gillis, Jennifer</au><au>Cooper, Curtis</au><au>Rourke, Sean</au><au>Rueda, Sergio</au><au>O'Brien, Kelly</au><au>Collins, Evan</au><au>Rachlis, Anita</au><au>Hart, Trevor A.</au><au>Raboud, Janet</au><aucorp>OHTN Cohort Study Group</aucorp><aucorp>OHTN Cohort Study Group</aucorp><aucorp>the OHTN Cohort Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals</atitle><jtitle>Quality of life research</jtitle><stitle>Qual Life Res</stitle><addtitle>Qual Life Res</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>22</volume><issue>7</issue><spage>1525</spage><epage>1535</epage><pages>1525-1535</pages><issn>0962-9343</issn><eissn>1573-2649</eissn><abstract>Purpose Concurrent infection with HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) often occurs due to the commonality in risk factors for acquisition. Few studies have examined the effect of co-infection on health-related quality of life (HRQOL) in HIV positive individuals. Methods Ontario HIV Treatment Network Cohort Study (OCS) participants who completed an annual interviewer-administered questionnaire on up to three occasions were included. Generalized estimating equations (GEE) were used to assess the impact of HBV and HCV co-infection on physical and mental HRQOL component summary scores (range 0–100) as measured by the Medical Outcomes SF-36 health survey. Results As of March 2010, 1,223 participants had completed the questionnaire; 964 were HIV mono-infected, 128 were HIV–HBV co-infected, 112 were HIV–HCV co-infected, and 19 were HIV–HBV–HCV tri-infected. Eighty percent were male, median age 46 (IQR 40–53) years, 61 % Caucasian, median CD4 count 464 (IQR 319–636) cells/mm3, and 74 % had undetectable HIV viremia. Physical HRQOL was lower in HIV–HBV and HIV–HCV co-infected individuals (49.4 (IQR 42.0–53.9) and 48.1 (IQR 36.9–52.8) vs. 51.5 (IQR 45.0–55.4); p = 0.01 and <0.0001) compared to mono-infected individuals. In the multivariable GEE model, the negative impact of HCV remained significant (−2.18; p = 0.01) after adjusting for drug use, smoking, age, and gender. Unadjusted mental HRQOL was lower in HIV–HCV co-infected individuals (44.6 (IQR 34.6–54.0) vs. 48.9 (IQR 36.8–55.9); p = 0.03) compared to mono-infected individuals but no association of mental HRQOL with either co-infection was observed in multivariable GEE models. Conclusions HCV appears to negatively impact physical HRQOL suggesting a greater health burden for co-infected individuals. HBV and HCV co-infections were not related to lower mental HRQOL among people living with HIV/AIDS.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>23070749</pmid><doi>10.1007/s11136-012-0283-7</doi><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0962-9343 |
| ispartof | Quality of life research, 2013-09, Vol.22 (7), p.1525-1535 |
| issn | 0962-9343 1573-2649 |
| language | eng |
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| source | MEDLINE; SpringerLink_现刊; JSTOR |
| subjects | Acquired immune deficiency syndrome Adult Alcohol drinking CD4 Lymphocyte Count Cohort analysis Cohort Studies Coinfection Comorbidity Coping Demography Drug use Female Health care networks Health Status Health surveys Hepatitis Hepatitis B Hepatitis B - complications Hepatitis B virus Hepatitis C Hepatitis C - complications HIV HIV Infections - complications HIV Infections - psychology HIV Infections - virology HIV-1 - isolation & purification Hospitals Human immunodeficiency virus Humans Income estimates Infections Infectious diseases Laboratories Liver diseases Male Medicine Medicine & Public Health Mental depression Mental health Middle Aged Ontario P values Public Health Quality of Life Quality of Life Research Questionnaires Sickness Impact Profile Sociodemographics Socioeconomic Factors Sociology Standard scores Stigma Surveys and Questionnaires Tranquilizing agents Viral Load Viremia - complications Viremia - immunology |
| title | Impact of hepatitis B and C co-infection on health-related quality of life in HIV positive individuals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T22%3A42%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20hepatitis%20B%20and%20C%20co-infection%20on%20health-related%20quality%20of%20life%20in%20HIV%20positive%20individuals&rft.jtitle=Quality%20of%20life%20research&rft.au=Gillis,%20Jennifer&rft.aucorp=OHTN%20Cohort%20Study%20Group&rft.date=2013-09-01&rft.volume=22&rft.issue=7&rft.spage=1525&rft.epage=1535&rft.pages=1525-1535&rft.issn=0962-9343&rft.eissn=1573-2649&rft_id=info:doi/10.1007/s11136-012-0283-7&rft_dat=%3Cjstor_proqu%3E24725187%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1433065103&rft_id=info:pmid/23070749&rft_jstor_id=24725187&rfr_iscdi=true |