Anti-angiogenic therapy, a new player in the field of sarcoma treatment

Abstract Sarcomas encompass a heterogeneous family of mesenchymal malignancies. In metastatic disease improvement in outcome has been limited and there is a clear need for the development of new therapies. One potential target is angiogenesis, already an accepted target for treatment of more prevale...

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Veröffentlicht in:	Critical reviews in oncology/hematology 2014-08, Vol.91 (2), p.172-185
Hauptverfasser:	Versleijen-Jonkers, Yvonne M.H, Vlenterie, Myrella, van de Luijtgaarden, Addy C.M, van der Graaf, Winette T.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - therapeutic use Animals Bone and Bones - blood supply Bone and Bones - drug effects Bone and Bones - pathology Bone Neoplasms - blood supply Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Bone Neoplasms - pathology Chondrosarcoma Drug Evaluation, Preclinical Gastrointestinal Neoplasms - blood supply Gastrointestinal Neoplasms - drug therapy Gastrointestinal Neoplasms - metabolism Gastrointestinal Neoplasms - pathology Gastrointestinal Tract - blood supply Gastrointestinal Tract - drug effects Gastrointestinal Tract - pathology GIST Hematology, Oncology and Palliative Medicine Humans Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Osteosarcoma Sarcoma Sarcoma - blood supply Sarcoma - drug therapy Sarcoma - metabolism Sarcoma - pathology Soft tissue sarcoma Vascular Endothelial Growth Factor A - metabolism VEGF
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