Bioavailability of Therapeutic Proteins by Inhalation—Worker Safety Aspects

A literature review and analysis of inhalation bioavailability data for large therapeutic proteins was conducted in order to develop a practical estimate of the inhalation bioavailability of these drugs. This value is incorporated into equations used to derive occupational exposure limits(OELs) to p...

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Veröffentlicht in:	The Annals of occupational hygiene 2014-08, Vol.58 (7), p.899-911
Hauptverfasser:	PFISTER, Thomas, DOLAN, David, BERCU, Joel, GOULD, Janet, WANG, Bonnie, BECHTER, Rudolf, BARLE, Ester Lovsin, PFANNKUCH, Friedlieb, FLUECKIGER, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biological Availability Humans Immunoglobulin G - metabolism Inhalation Exposure Lung - metabolism Maximum Allowable Concentration Medical sciences Occupational Exposure - analysis Occupational Exposure - standards Occupational medicine Pharmaceutical Preparations - analysis Proteins - pharmacokinetics Proteins - therapeutic use Public health. Hygiene-occupational medicine Safety Threshold Limit Values Workplace
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